Glia-pinealocyte network: the paracrine modulation of melatonin synthesis by tumor necrosis factor (TNF). [PDF]
PLoS ONE, 2012 The pineal gland, a circumventricular organ, plays an integrative role in defense responses. The injury-induced suppression of the pineal gland hormone, melatonin, which is triggered by darkness, allows the mounting of innate immune responses.
Sanseray da Silveira Cruz-Machado +4 more
doaj +10 more sources
Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression. [PDF]
PLoS ONE, 2018 The vertebrate pineal gland is dedicated to the production of the hormone melatonin, which increases at night to influence circadian and seasonal rhythms. This increase is associated with dramatic changes in the pineal transcriptome.
Joseph C Mays +6 more
doaj +3 more sources
MICROCYLINDERS WITHIN MITOCHONDRIAL CRISTAE IN THE RAT PINEALOCYTE [PDF]
The Journal of Cell Biology, 1965 A minute cylindrical structure with a dense core, designated as "microcylinder," has been observed within enlarged spaces of mitochondrial cristae in pinealocytes of some adult rats (osmium tetroxide fixed, methacrylate embedded).
Huai‐San Lin
semanticscholar +5 more sources
The pinealocyte--a paraneuron? A review.
Archivum histologicum japonicum, 1977 The pineal complex develops from a tubular evagination of the diencephalic roof. In amphibians a proliferation zone is the source of the pinealocytes and of the cells of the subcommissural organ.
M. Ueck, K. Wake
semanticscholar +6 more sources
Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats [PDF]
Antioxidants, 2023 Concerns have been raised regarding the potential adverse health effects of the ubiquitous herbicide glyphosate. Here, we investigated long-term effects of developmental exposure to a glyphosate-based herbicide (GBH) by analyzing serum melatonin levels ...
Daiane Cattani +4 more
doaj +2 more sources
Profiling Temporal Changes of the Pineal Transcriptomes at Single Cell Level Upon Neonatal HIBD [PDF]
Frontiers in Cell and Developmental Biology, 2022 Neonatal hypoxic-ischemic brain damage (HIBD) often results in various neurological deficits. Among them, a common, yet often neglected, symptom is circadian rhythm disorders. Previous studies revealed that the occurrence of cysts in the pineal gland, an
Xin Ding +14 more
doaj +2 more sources
Cytodifferentiation of pinealocytes (I and II) and astrocyte types of mature male sheep epiphysis cerebri with special emphasis on the presence of neuronal and pigmented like cells [PDF]
Open Veterinary Journal, 2023 Background: The epiphysis cerebri (pineal gland) is a small-sized, photo neuroendocrine organ in the brain of most vertebrates. Their effect is through secretion of melatonin, a serotonin-derived hormone which is stimulated by darkness and inhibited by ...
Naief Dahran, Wael A. M. Ghonimi
doaj +2 more sources
Morphology of the Human Pineal Gland Studied by Freeze-Fracturing in Scanning Electron Microscopy [PDF]
LifeThe human pineal gland is the largest producer of the hormone melatonin. Pineal acervuli (brain sand), calcified concretions in the pineal gland, have long been studied because of their association with ageing, melatonin production, and neurological ...
Simona Polakovičová +3 more
doaj +2 more sources
A PECULIAR CONFIGURATION OF AGRANULAR RETICULUM (CANALICULATE LAMELLAR BODY) IN THE RAT PINEALOCYTE [PDF]
Journal of Cell Biology, 1967 A cytoplasmic structure exhibiting a peculiar configuration of agranular reticulum has been found in the rat pinealocyte, and has been designated a canaliculate lamellar body.
Huai‐San Lin
semanticscholar +2 more sources
Sex-Specific Methylomic and Transcriptomic Responses of the Avian Pineal Gland to Unpredictable Illumination Patterns. [PDF]
J Pineal ResABSTRACT In the production environment of chickens, exposure to unpredictable light patterns is a common painless stressor, widely used to influence growth rate and egg production efficiency. The pineal gland, a key regulator of circadian rhythms through melatonin secretion, responds to environmental light cues, and its function is modulated by ...
Pértille F +8 more
europepmc +2 more sources