Results 1 to 10 of about 23,348 (143)
Vnitřní lékařství, 2020 Pioglitazone belongs to the drugs primarily reducing insulin resistance. Currently, it is the only insulin sensitizer available. In addition to hypoglycaemic action, it has a number of other metabolically beneficial effects that are responsible for its positive effect on the vascular wall.
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The efficacy of pioglitazone for renal protection in diabetic kidney disease
PLoS ONE, 2022 There is limited information on the efficacy of pioglitazone in diabetic kidney diseases (DKD). We evaluated whether pioglitazone exerts renal-protective effects in DKD patients.
Chao-Chung Ho +5 more
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International Journal of Clinical Practice, 2000 SUMMARYPioglitazone is a thiazolidinedione. As a PPAR‐γ agonist it alters the expression of a number of genes, resulting in a reduction in insulin resistance. Clinical trial data involving over 4500 patients with type 2 diabetes suggest it is effective both as monotherapy and in combination with sulphonylureas, metformin and insulin, producing both ...
J M, Lawrence, J P, Reckless
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Molecules, 2023 Pioglitazone, a PPAR-gamma activator used to diagnose hyperglycemia, was studied for its stereoselective deposition and active enantiomers in female albino Wistar rats.
Tatineni Spandana +8 more
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Hepatology Communications, 2021 The antidiabetic drug pioglitazone is, to date, the most efficacious oral drug recommended off‐label for the treatment of nondiabetic or diabetic patients with biopsy‐proven nonalcoholic steatohepatitis (NASH). However, weight gain and edema side effects
Vincent Jacques +8 more
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Pioglitazone - the forgotten drug with multidirectional action
Journal of Education, Health and Sport, 2023 Introduction: Pioglitazone (PG) which belongs to thiazolidinedione class is a drug used in the treatment of type 2 diabetes. PG increases the insulin sensitivity of peripheral tissues.
Arkadiusz Aab, Julia Zarańska
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Pioglitazone Alters the Proteomes of Normal Bladder Epithelial Cells but Shows No Tumorigenic Effects [PDF]
International Neurourology Journal, 2020 Purpose Pioglitazone, an antihyperglycemic drug, is widely used in diabetes mellitus patients with insulin resistance. Although pioglitazone is known to have a potential link to bladder cancer (BC), there have been contradictory results.
Muhammad Shahid +6 more
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Pioglitazone abrogates testicular damage induced by testicular torsion/detorsion in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Testicular torsion/detorsion (T/D) is a well-known cause for infertility. Pioglitazone is an agonist of peroxisome proliferator activated receptor-gamma (PPAR-γ).
Nevertyty Mohamed Mahmoud +1 more
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Drugs - Real World Outcomes, 2019 Introduction A Direct Healthcare Professional Communication (DHPC) sent in Denmark on 11 August 2011 provided information on new pioglitazone labelling and guidance on monitoring treatment effectiveness.
Javier Cid Ruzafa +3 more
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Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21(waf1/cip1) [PDF]
, 2001 Background/Aims: We investigated the effect of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist pioglitazone on growth and TRAIL-induced apoptosis in carcinoid cells.
Chen, Youhai +4 more
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