Results 41 to 50 of about 51,359 (234)

Проблемы разработки стратегии построения технологии контекстного обучения педагогов [PDF]

, 2001
AIMS/HYPOTHESIS: The evidence on the association between pioglitazone use and bladder cancer is contradictory, with many studies subject to allocation bias. The aim of our study was to examine the effect of exposure to pioglitazone on bladder cancer risk
Badrick, Ellena, Bell, Samira, Bowker, Samantha L, Buchan, Iain E, Colhoun, Helen M, de Keyser, Catherine E, Hartikainen, Sirpa A, Hofman, Albert, Johnson, Jeffrey A, Keskimaki, I, Keskimäki, Ilmo, Levin, Daniel, MacDonald, Thomas M, Marra, Carlo, McKeigue, Paul M, Minhas-Sandhu, Jasjeet K, Pukkala, Eero, Renehan, Andrew G, Ruiter, Rikje, Stricker, Bruno H, Sund, Reijo, Tuomilehto, Jaakko, Uitterlinden, Andrè G, Wild, Sarah H, Zafari, Zafar   +24 more
core   +1 more source

Current clinical evidence on pioglitazone pharmacogenomics

Frontiers in Pharmacology, 2013
Pioglitazone is the most widely used thiazolidinedione and acts as an insulin-sensitizer through activation of the Peroxisome Proliferator-Activated Receptor-γ (PPARγ).
Marina eKawaguchi-Suzuki, Reginald F. Frye   +1 more
doaj   +1 more source

The anti-atherogenic effects of thiazolidinediones [PDF]

, 2007
The thiazolidinediones (TZDs) rosiglitazone (ROS) and pioglitazone (PIO) are insulin-sensitising agents widely used to treat patients with type 2 diabetes mellitus (T2DM). Thiazolidinediones significantly improve glycaemic control in diabetics by reduced
Honisett, Suzy, Komesaroff, Paul A, Stojanovska, Lily   +2 more
core  

Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis [PDF]

, 2016
This project was supported through a studentship awarded by the Plymouth University Peninsula Schools of Medicine and Dentistry.Proliferator-activated receptor γ (PPARγ) activation can result in transcription of proteins involved in oxidative stress ...
Carroll, CB, Eastwood, J, Hanemann, OC, McCorry, K, Zajicek, JP, Zeissler, M-L   +5 more
core   +3 more sources

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Type 2 Diabetic Sepsis Patients Have a Lower Mortality Rate in Pioglitazone Use: A Nationwide 15-Year Propensity Score Matching Observational Study in Taiwan

Emergency Medicine International, 2021
Background. Pioglitazone use via the PPARγ agonist in sepsis patients is inconclusive. It was based on a great number of animal studies. However, except for information from animal studies, there are merely any data of human studies for reference ...
Ming-Shun Hsieh, Sung-Yuan Hu, Shu-Hui Liao, Chia-Ming Chang, Vivian Chia-Rong Hsieh, Chorng-Kuang How   +5 more
doaj   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Pioglitazone and the risk of bladder cancer: An Indian retrospective cohort study

Indian Journal of Endocrinology and Metabolism, 2015
Aim: To determine whether pioglitazone is associated with an increased risk of bladder cancer among Indian type 2 diabetic patients. Methods: A retrospective data analysis of 2222 type 2 diabetic patients was conducted.
Sunil Gupta, Kavita Gupta, R Ravi, Vinita Mehta, Samar Banerjee, Shashank Joshi, Banshi Saboo   +6 more
doaj   +1 more source

Beneficial effects of canagliflozin in combination with pioglitazone on insulin sensitivity in rodent models of obese type 2 diabetes. [PDF]

PLoS ONE, 2015
BACKGROUND:Despite its insulin sensitizing effects, pioglitazone may induce weight gain leading to an increased risk of development of insulin resistance.
Yoshinori Watanabe, Keiko Nakayama, Nobuhiko Taniuchi, Yasushi Horai, Chiaki Kuriyama, Kiichiro Ueta, Kenji Arakawa, Takaaki Senbonmatsu, Masaharu Shiotani   +8 more
doaj   +1 more source

Pioglitazone Reverses Markers of Islet Beta-Cell De-Differentiation in db/db Mice While Modulating Expression of Genes Controlling Inflammation and Browning in White Adipose Tissue from Insulin-Resistant Mice and Humans

Biomedicines, 2021
Obesity, insulin resistance, and type 2 diabetes contribute to increased morbidity and mortality in humans. The db/db mouse is an important mouse model that displays many key features of the human disease.
J. Jason Collier, Heidi M. Batdorf, Kaelan L. Merrifield, Thomas M. Martin, Ursula White, Eric Ravussin, David H. Burk, Chris R. Cooley, Michael D. Karlstad, Susan J. Burke   +9 more
doaj   +1 more source