Results 121 to 130 of about 31,206 (230)

Long Polyamines Act as Cofactors in PIP2 Activation of Inward Rectifier Potassium (Kir2.1) Channels [PDF]

, 2005
Phosphatidylinosital-4,5-bisphosphate (PIP2) acts as an essential factor regulating the activity of all Kir channels. In most Kir members, the dependence on PIP2 is modulated by other factors, such as protein kinases (in Kir1), G(betagamma) (in Kir3 ...
Weiss, James N, Lai-Hua Xie, Bernard Ribalet, Ribalet, Bernard, Scott A. John, James N. Weiss, Xie, Lai-Hua, John, Scott A   +7 more
core   +1 more source

Targeting the PI3K/Akt Signaling Pathway: A Promising Therapeutic Strategy to Reduce Cancer Mortality and Overcome Chemoresistance

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims The phosphatidylinositol 3‐kinase (PI3K)/Akt signaling pathway is a central regulator of cellular properties that are essential for cancer progression, including cellular growth, survival, metabolism, and angiogenesis. Dysregulated PI3K/Akt signaling, often caused by genetic alterations in PIK3CA, loss of PTEN, or the ...
Md Mohiuddin
wiley   +1 more source

Myosin-PIP2 interaction in the cell nucleus

, 2013
Even though nuclear myosin 1 (NM1) and myosin 1C (Myo1C) are the products of the same gene, NM1 has additional 16 amino acids at the N-terminus due to alternative start of transcription.
Yildirim, Sükriye
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Cells adapt to extracellular acidic pH through TM9SF3-mediated PI(4,5)P2 flop

Nature Communications
The plasma membrane (PM), a physical barrier separating cells from their environment, responds to fluctuating extracellular environment through receptor-mediated signaling. While these pathways have been extensively studied, the role of PM lipids remains
Keisuke Sako, Yusuke V. Morimoto, Shin Morioka, Junya Hasegawa, Hiroyuki Nakajima, Moe Fukumoto, Yuya Nishida, Yasunori Shintani, Junko Sasaki, Takehiko Sasaki, Kazu Kikuchi, Naoki Mochizuki   +11 more
doaj   +1 more source

Molecular mechanism of GIRK2 channel gating modulated by cholesteryl hemisuccinate

Frontiers in Physiology
Cholesterol, an essential lipid of cell membranes, regulates G protein-gated inwardly rectifying potassium (GIRK) channel activity. Previous studies have shown that cholesterol activates GIRK2 homotetrameric channels, which are expressed in dopaminergic ...
Meng Cui, Meng Cui, Yongcheng Lu, Xinyi Ma, Diomedes E. Logothetis, Diomedes E. Logothetis, Diomedes E. Logothetis, Diomedes E. Logothetis, Diomedes E. Logothetis   +8 more
doaj   +1 more source

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source

Structural and functional insights into the lipid regulation of human anion exchanger 2

Nature Communications
Anion exchanger 2 (AE2) is an electroneutral Na+-independent Cl-/HCO3 - exchanger belongs to the SLC4 transporter family. The widely expressed AE2 participates in a variety of physiological processes, including transepithelial acid-base secretion and ...
Weiqi Zhang, Dian Ding, Yishuo Lu, Hongyi Chen, Peijun Jiang, Peng Zuo, Guangxi Wang, Juan Luo, Yue Yin, Jianyuan Luo, Yuxin Yin   +10 more
doaj   +1 more source

Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.

PLoS ONE, 2017
The slow delayed-rectifier potassium current (IKs) is crucial for human cardiac action potential repolarization. The formation of IKs requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can lead to ...
Alice A Royal, Andrew Tinker, Stephen C Harmer   +2 more
doaj   +1 more source

Identification of Sodium/Myo‐Inositol Transporter 1 as a Major Determinant of Arterial Contractility

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
The tonicity‐responsive enhancer binding‐protein (TonEBP) and serum glucocorticoid kinase (SGK) sense a rise in extracellular hypertonicity resulting in an increase SMIT1 membrane abundance in vascular smooth muscle cells. SMIT1 associates with Kv7.4/5, Gβγ, and KCNE4, promoting hyperpolarization, reduced voltage‐gated calcium channel (VGCC) opening ...
Elizabeth A. Forrester, Skye Lau, Miguel Benitez‐Angeles, Christopher J. Garland, Vincenzo Barrese, Anthony P. Albert, Iain A. Greenwood   +6 more
wiley   +1 more source

PIP2 as local second messenger: a critical re-evaluation [PDF]

, 2006
Phosphatidylinositol 4,5-biphosphate (PIP2) has been proposed to act as a second messenger in the regulation of many cell processes. If so, then PIP2 should fulfill two important criteria's: first PIP2 levels should vary spatially or temporally under ...
Rheenen, Jacobus Emiel van
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