Results 101 to 110 of about 31,206 (230)
Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow
The Journal of Physiology, EarlyView.Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley +1 more source
Allosteric Regulation of Focal Adhesion Kinase by PIP2 and ATP [PDF]
, 2015 Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that regulates cell signaling, proliferation, migration, and development. A major mechanism of regulation of FAK activity is an intramolecular autoinhibitory interaction between two of its ...
Bronowska, Agnieszka +4 more
core +1 more source
Phosphatidylinositol-4,5-bisphosphate enhances anionic lipid demixing by the C2 domain of PKCα.
PLoS ONE, 2014 The C2 domain of PKCα (C2α) induces fluorescence self-quenching of NBD-PS in the presence of Ca2+, which is interpreted as the demixing of phosphatidylserine from a mixture of this phospholipid with phosphatidylcholine.
Antonio L Egea-Jiménez +5 more
doaj +1 more source
Levodopa‐Responsive Parkinsonism Preceded by Isolated Upper Limb Tremor Associated with PTEN Variant
Movement Disorders Clinical Practice, EarlyView.
Sacha E. Gandhi +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura +4 more
wiley +1 more source
Selective Phosphorylation Modulates the PIP2 Sensitivity of the CaM-SK Channel Complex [PDF]
, 2014 Phosphatidylinositol bisphosphate (PIP2) regulates the activities of many membrane proteins including ion channels through direct interactions. However, the affinity of PIP2 is so high for some channel proteins that its physiological role as a modulator ...
Zhang, Miao +11 more
core +1 more source
Regulation of WASP: PIP2 Pipped by Toca-1?
Cell, 2004 Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP.
Insall, Robert H, Machesky, Laura M
openaire +2 more sources
Spectroscopic characterization of PTEN/PIP2 interaction
The FASEB Journal, 2006 PTEN, a phosphatase that dephosphorylates the 3′ position of phosphoinositides, is a tumor suppressor. Activation of PTEN by PI‐4,5‐P 2 requires a polybasic region at the N‐terminus. It was hypothesized that PI‐4,5‐P 2 aids membrane recruiting and ...
Arne Gericke +4 more
openaire +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
The Journal of Cell Biology, 2007 ![Graphic][1] The breakdown of PI(4,5)P2 by a phosphatase (green) allows endocytosis (red) to complete. Sites of endocytosis are enriched in PI(4,5)P 2, but its removal is required for endocytosis to be completed, report Sun et al. (page [355][2]).
openaire +1 more source