Results 91 to 100 of about 26,558 (201)

The Na+/H+ Exchanger-3 (NHE3) Activity Requires Ezrin Binding to Phosphoinositide and Its Phosphorylation.

open access: yesPLoS ONE, 2015
Na+/H+ exchanger-3 (NHE3) plays an essential role in maintaining sodium and fluid homeostasis in the intestine and kidney epithelium. Thus, NHE3 is highly regulated and its function depends on binding to multiple regulatory proteins. Ezrin complexed with
Victor Babich, Francesca Di Sole
doaj   +1 more source

PIP2 in endocytosis [PDF]

open access: yesThe Journal of Cell Biology, 2007
![Graphic][1] The breakdown of PI(4,5)P2 by a phosphatase (green) allows endocytosis (red) to complete. Sites of endocytosis are enriched in PI(4,5)P 2, but its removal is required for endocytosis to be completed, report Sun et al. (page [355][2]).
openaire   +1 more source

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

open access: yesAnalytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
wiley   +1 more source

In silico Coding Sequence Analysis of Walnut GAI and PIP2 Genes and Comparison with Different Plant Species

open access: yesMajallah-i ̒Ulum-i Bāghbānī, 2017
Introduction: Dwarfism is one of the important traits in breeding of crops and horticulture plants. A dwarfing rootstock will produce trees with 15-50% of standard trees size. In modern intensive fruit tree orchards, dwarfing rootstocks are commonly used
Mahdi Mohseniazar   +2 more
doaj   +1 more source

From Capability to Care: Sense‐Breaking, Sense‐Giving, and Strategic Flexibility as Drivers of Ethical, Autonomy‐Preserving AI Personalization

open access: yesPsychology &Marketing, Volume 43, Issue 6, Page 1418-1431, June 2026.
ABSTRACT AI‐driven personalization now structures search, recommendation, pricing, and service across the consumer journey, heightening a core dilemma: maximizing relevance and efficiency without compromising autonomy and trust. This article advances a capability‐based account of responsible personalization.
Yu‐Ming Hsu
wiley   +1 more source

Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.

open access: yesPLoS ONE, 2017
The slow delayed-rectifier potassium current (IKs) is crucial for human cardiac action potential repolarization. The formation of IKs requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can lead to ...
Alice A Royal   +2 more
doaj   +1 more source

Intrinsically dominant conformational diversity in PDZ1 within the tandem PDZ1–PDZ2 of human syntenin‐1 underlined by crystal structures

open access: yesProtein Science, Volume 35, Issue 6, June 2026.
Abstract The intrinsic dynamic asymmetry between homologous PDZ domains in multidomain scaffold proteins offers insight into how they achieve multivalent partner recognition. Through a systematic x‐ray crystallographic analysis of tandem PDZ1–PDZ2 domains in human syntenin‐1 (SDCBP/MDA‐9), we solved nine high‐resolution structures and uncovered ...
Natsuno Ando   +8 more
wiley   +1 more source

Traversing the effects of ploidy changes in different Eragrostis curvula genotypes through high‐throughput RNA sequencing

open access: yesThe Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Polyploidization has played a key role in plant genome evolution. Eragrostis curvula (Schrad.) Ness, a perennial forage grass species of the Poaceae family, is an excellent model for investigating genome duplication due to its natural variation in ploidy levels.
D. F. Santoro   +5 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, Volume 20, Issue 5, Page 1299-1322, May 2026.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Structural and functional insights into the lipid regulation of human anion exchanger 2

open access: yesNature Communications
Anion exchanger 2 (AE2) is an electroneutral Na+-independent Cl-/HCO3 - exchanger belongs to the SLC4 transporter family. The widely expressed AE2 participates in a variety of physiological processes, including transepithelial acid-base secretion and ...
Weiqi Zhang   +10 more
doaj   +1 more source

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