Results 71 to 80 of about 26,558 (201)

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux

Communications Biology, 2022
Phosphatidylinositol 4,5-bisphosphate (PIP2) directly regulates norepinephrine transporter (NET) dimer stabilization at the plasma membrane. Furthermore, PIP2 interaction with NET affects efflux.
Dino Luethi, Julian Maier, Deborah Rudin, Dániel Szöllősi, Thomas J. F. Angenoorth, Stevan Stankovic, Matthias Schittmayer, Isabella Burger, Jae-Won Yang, Kathrin Jaentsch, Marion Holy, Anand Kant Das, Mario Brameshuber, Gisela Andrea Camacho-Hernandez, Andrea Casiraghi, Amy Hauck Newman, Oliver Kudlacek, Ruth Birner-Gruenberger, Thomas Stockner, Gerhard J. Schütz, Harald H. Sitte   +20 more
doaj   +1 more source

Dual Regulation of Kv1.2 Activation by PIP2 [PDF]

Biophysical Journal, 2011
Phosphatidylinositol (4,5)-bisphosphate is now recognized as a ubiquitous regulator of ion channels and transporters. We report here that PIP2 regulates activation of Kv1.2, a Shaker family voltage-gated potassium channel. In inside-out macropatches of Xenopus laevis oocytes, loss of PIP2 induced a leftward shift in the voltage-dependence of activation
Rodriguez-Menchaca, Aldo A., Adney, Scott K., Logothetis, Diomedes E.   +2 more
openaire   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, EarlyView.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

Depletion of Cholesterol Reduces ENaC Activity by Decreasing Phosphatidylinositol-4,5-Bisphosphate in Microvilli

Cellular Physiology and Biochemistry, 2018
Background/Aims: The epithelial sodium channel (ENaC) in cortical collecting duct (CCD) principal cells plays a critical role in regulating systemic blood pressure.
Yu-Jia Zhai, Bing-Chen Liu, Shi-Peng Wei, Chu-Fang Chou, Ming-Ming Wu, Bin-Lin Song, Valerie A. Linck, Li Zou, Shuai Zhang, Xue-Qi Li, Zhi-Ren Zhang, He-Ping Ma   +11 more
doaj   +1 more source

A leucine‐rich‐repeat receptor‐like kinase SERL1 phosphorylates and stabilizes OsALDH2B1 to promote alkaline tolerance and grain size in rice

Journal of Integrative Plant Biology, EarlyView.
The rice aldehyde dehydrogenase OsALDH2B1 enhances grain size and tolerance to alkaline soil by repressing GRAIN SIZE 3 and activating catalases. SERL1‐mediated phosphorylation stabilizes OsALDH2B1 under stress, establishing a signaling axis that overcomes growth‐defense trade‐offs and provides a direct target for breeding high‐yield, alkaline ...
Zemin Ma, Xuanlin Gao, Shuaizu An, Mengyuan Chen, Biaoming Zhang, Lei Zhou, Shengyuan Sun, Ming Li, Feng Yu, Shiyou Lü, Zhaohui Chu, Aiqing You, Yinggen Ke, Pingfang Yang   +13 more
wiley   +1 more source

How cholesterol regulates endothelial biomechanics

Frontiers in Physiology, 2012
As endothelial cells form the barrier between blood flow and surrounding tissue, many of their functions depend on mechanical integrity, in particular that of the plasma membrane.
Zhongkui eHong, Marius Catalin Staiculescu, Paul eHampel, Irena eLevitan, Gabor eForgacs, Gabor eForgacs, Gabor eForgacs   +6 more
doaj   +1 more source