Results 71 to 80 of about 31,206 (230)

PIP2-dependent coupling of voltage sensor and pore domains in Kv7.2 channel

Communications Biology, 2021
Pant et al. describe the mechanism by which PIP2 might regulate homomeric Kv7.2 channels. They identify sites important in the binding of the PIP2 lipid to Kv7.2 channels and propose that the PIP2 binding to a specific site results in the coupling ...
Shashank Pant, Jiaren Zhang, Eung Chang Kim, Kin Lam, Hee Jung Chung, Emad Tajkhorshid   +5 more
doaj   +1 more source

Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2

eLife, 2022
Phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 4,5-biphosphate (PIP2) are key phosphoinositides that determine the identity of the plasma membrane (PM) and regulate numerous key biological events there.
Juan Lu, Wei Dong, Gerald R Hammond, Yang Hong   +3 more
doaj   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

Nature Communications
ATP-sensitive potassium (KATP) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in pancreatic β-cells.
Camden M. Driggers, Yi-Ying Kuo, Phillip Zhu, Assmaa ElSheikh, Show-Ling Shyng   +4 more
doaj   +1 more source

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

Cell Reports, 2018
Summary: Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms ...
Wang Zheng, Ruiqi Cai, Laura Hofmann, Vasyl Nesin, Qiaolin Hu, Wentong Long, Mohammad Fatehi, Xiong Liu, Shaimaa Hussein, Tim Kong, Jingru Li, Peter E. Light, Jingfeng Tang, Veit Flockerzi, Leonidas Tsiokas, Xing-Zhen Chen   +15 more
doaj   +1 more source

From ‘Responsible’ to ‘Sustainable’: A Contingent Analysis of Responsible Entrepreneurship and Product Innovation Performance in an Emerging Economy

Business Strategy and the Environment, EarlyView.
ABSTRACT While debate on responsible entrepreneurial activities for sustainable development is burgeoning, studies examining whether small and medium‐sized firms (SMEs) can benefit from responsible entrepreneurship remain underexplored. In this study, we draw on stakeholder theory to fill this literature gap by investigating the effect of responsible ...
Ayodele C. Oniku, Awele Achi, Adejumoke Adeoti, Olamide O. Akintimehin, Francis Chukwuedo Achi, Solomon Jeresa, Benard Iyegudu   +6 more
wiley   +1 more source

Regulation of sperm motility by PIP2(4,5) and actin polymerization [PDF]

, 2013
Actin polymerization and development of hyperactivated (HA) motility are two processes that take place during sperm capacitation. In previous studies, we demonstrated that the increase in F-actin during capacitation depends upon inactivation of the actin
Breitbart, Haim, Megnagi, Bar, Ickowicz, Debby, Finkelstein, Maya   +3 more
core   +1 more source

The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization

PLOS ONE, 2015
Translocation to the nucleus of diacylglycerol kinase (DGK)- ζ is dependent on a sequence homologous to the effector domain of Myristoylated Alanine Rich C-Kinase Substrate (MARCKS). These data would suggest that MARCKS could also localize to the nucleus.
Timothy D Rohrbach, Nishi Shah, William P Jackson, Erin V Feeney, Samantha Scanlon, Robert Gish, Ryan Khodadadi, Stephen O Hyde, Patricia H Hicks, Joshua C Anderson, John S Jarboe, Christopher D Willey   +11 more
openaire   +4 more sources

Identification of postsynaptic phosphatidylinositol-4,5-bisphosphate (PIP2) roles for synaptic plasticity using chemically induced dimerization

Scientific Reports, 2017
Phosphatidylinositol-4,5-bisphosphate (PIP2), one of the key phospholipids, directly interacts with several membrane and cytosolic proteins at neuronal plasma membranes, leading to changes in neuronal properties including the feature and surface ...
Su-Jeong Kim, Min-Jae Jeong, Hee-Jung Jo, Jung Hoon Jung, Bong-Kiun Kaang, Yun-Beom Choi, Joung-Hun Kim   +6 more
doaj   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source