Results 81 to 90 of about 31,206 (230)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with a high rate of recurrence and metastasis, necessitating the identification of novel therapeutic targets. WD repeat‐containing protein 72 (WDR72) has been linked to various cancers, but its specific biological function and underlying mechanism in ESCC remain largely ...
Hao Wu, Zhong‐Xiang Jiang, Zheng Jiang
wiley +1 more source
GCGR PIP2 interaction data nMS
, 2022 Native Mass Spectra of GCGR and phospholipids, POPS, POPA, POPG, and PI(4,5)P2.
Yan, Jun, Sørensen, Lars
openaire +1 more source
Neuroprotection, EarlyView.Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu +7 more
wiley +1 more source
Studies on PIP2-bisphosphomonoesterase activity in human platelets.
Blood & Vessel, 1988 An occurrence of phosphatidylinositol 4,5-bisphosphate (PIP2) phosphomonoesterase in human platelets was demonstrated by analyzing phosphoinositides metabolism. The activity of the enzyme was maximum at pH 7.0. It was active even in the absence of Ca2+ or Mg2+ but it was enhanced in the presence of Mg2+ or NaF.
UEMURA, Yoshio +4 more
openaire +3 more sources
The PIP2 binding mode of the C2 domains of rabphilin‐3A [PDF]
Protein Science, 2008 AbstractPhosphatidylinositol‐4,5‐bisphosphate (PIP2) is a key player in the neurotransmitter release process. Rabphilin‐3A is a neuronal C2 domain tandem containing protein that is involved in this process. Both its C2 domains (C2A and C2B) are able to bind PIP2.
Montaville, P. +5 more
openaire +3 more sources
Phytotherapy Research, EarlyView.This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren +10 more
wiley +1 more source
Below the NK-cell surface: PIP2
Blood, 2008 In this issue Blood, Micucci and colleagues demonstrate that PIP2 plays an essential role in NK-cell cytotoxicity by controlling the release of lytic mediators at the NK cell-target interface.
openaire +3 more sources
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
Myosin-PIP2 interakce v buněčném jádře [PDF]
, 2013 Even though nuclear myosin 1 (NM1) and myosin 1C (Myo1C) are the products of the same gene, NM1 has additional 16 amino acids at the N-terminus due to alternative start of transcription.
Yildirim, Sükriye
core
PIP2結合タンパク質による脂質膜中のPIP2認識の構造基盤
, 2022 イノシトール（4, 5）2リン酸（PIP2）は生体膜に存在し、様々なタンパク質と結合することでシグナル伝達や細胞の形態形成などの生理機能を担う。したがって、PIP2結合タンパク質がどのようにして細胞膜中のPIP2を認識するのかを解明することは、生命現象の理解につながる。そこで本研究では、PIP2結合タンパク質と脂質二重膜中のPIP2との相互作用を定量的に調べるため、PIP2含有リポソームとPIP2結合タンパク質の共沈降実験系を確立した ...
横川, 真梨子
core