Results 111 to 120 of about 31,206 (230)
PLoS ONE, 2015 Na+/H+ exchanger-3 (NHE3) plays an essential role in maintaining sodium and fluid homeostasis in the intestine and kidney epithelium. Thus, NHE3 is highly regulated and its function depends on binding to multiple regulatory proteins. Ezrin complexed with
Victor Babich, Francesca Di Sole
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley +1 more source
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
Expression of PIP2-5 in Maize Root Systems under Water Deficit
, 2006 在PEG-6000模拟水分亏缺条件下,以微管蛋白基因为内参基因,水通道蛋白基因PIP2-5为检测基因,采用半定量逆转录聚合酶链式反应(RT-PCR)体系检测PIP2-5基因在玉米根系中的表达的结果表明,人工模拟水分亏缺条件下PIP2-5基因表达量高于正常水分条件下的。这暗示,水分亏缺条件下细胞 ...
吴安慧, 邓西平, 山仑, 张岁岐
core
Inhibition of human TRPC5 activity by PIP2
The FASEB Journal, 2006 Phosphatidylinositol 4,5‐bisphosphate (PIP2) has important regulatory roles in many cellular process. Several members of the TRPM and TRPV ion channel families have been shown to be regulated by PIP2. Using a HEK293 cell line stably expressing human TRPC5, we tested whether the function of TRPC5 is also regulated by PIP2 ...
Fanning Zeng, Damian McHugh, David Beech
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The Journal of Physiology, EarlyView.Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley +1 more source
Majallah-i ̒Ulum-i Bāghbānī, 2017 Introduction: Dwarfism is one of the important traits in breeding of crops and horticulture plants. A dwarfing rootstock will produce trees with 15-50% of standard trees size. In modern intensive fruit tree orchards, dwarfing rootstocks are commonly used
Mahdi Mohseniazar +2 more
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The Journal of Physiology, EarlyView.Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista +11 more
wiley +1 more source
Cancer Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav +4 more
wiley +1 more source
, 2013 (A) To examine the role of ezrin T567 phosphorylation and/or binding to PIP2 in invadopodial-dependent focal digestion of the ECM, MDA-MB-231 cells were (A) transfected with empty cDNA (Control) or plasmids contain ezrin cDNA mutated in the T567 site to ...
Ester Antelmi (462473) +9 more
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