Results 161 to 170 of about 58,639 (259)
Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG
Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 367-378, February 2026.ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen +18 more
wiley +1 more source
Biophysical modelling of a drosophila photoreceptor [PDF]
, 2009 It remains unclear how visual information is co-processed by different layers of neurons in the retina. In particular, relatively little is known how retina translates vast environmental light changes into neural responses of limited range.
Billings, S. +5 more
core
Critique of a Radically New Model for Plasma Membrane Bilayer Organization
BioEssays, Volume 48, Issue 2, February 2026.We critique a model by Doktorova et al. (doi.org/10.1016/j.cell.2025.02.034) that challenges textbook depictions of the distribution of lipids in plasma membrane bilayers. They propose that the outer leaflet has about half as many phospholipids as the inner leaflet (left figure) and is compensated for by an excess of cholesterol (right figure ...
Yvonne Lange, Theodore L. Steck
wiley +1 more source
PLoS ONE, 2017 The slow delayed-rectifier potassium current (IKs) is crucial for human cardiac action potential repolarization. The formation of IKs requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can lead to ...
Alice A Royal +2 more
doaj +1 more source
, 2006 Andersen-Tawil syndrome (ATS) is a rare condition consisting of ventricular arrhythmias, periodic paralysis, and dysmorphic features. In 2001, mutations in KCNJ2, which encodes the α subunit of the potassium channel Kir2.1, were identified in patients ...
Fish, Frank A +2 more
core +2 more sources
Cancer Medicine, Volume 15, Issue 2, February 2026.ABSTRACT Background Colorectal cancer (CRC) is a leading cause of cancer‐related deaths, with metabolic reprogramming involved in its pathogenesis. Aberrant Arginase 2 (ARG2) expression is linked to malignant progression, but its role in CRC remains unclear. Methods ARG2 expression in CRC and adjacent tissues was analyzed.
Yueyan Zhang +9 more
wiley +1 more source
Structural and functional insights into the lipid regulation of human anion exchanger 2
Nature CommunicationsAnion exchanger 2 (AE2) is an electroneutral Na+-independent Cl-/HCO3 - exchanger belongs to the SLC4 transporter family. The widely expressed AE2 participates in a variety of physiological processes, including transepithelial acid-base secretion and ...
Weiqi Zhang +10 more
doaj +1 more source
Molecular mechanism of GIRK2 channel gating modulated by cholesteryl hemisuccinate
Frontiers in PhysiologyCholesterol, an essential lipid of cell membranes, regulates G protein-gated inwardly rectifying potassium (GIRK) channel activity. Previous studies have shown that cholesterol activates GIRK2 homotetrameric channels, which are expressed in dopaminergic ...
Meng Cui +8 more
doaj +1 more source
, 2015 Let $(M,g)$ be an open, oriented and incomplete riemannian manifold of dimension $m$. Under some general conditions we show that it is possible to build a Hilbert complex $(L^2\Omega^i(M,g),d_{\mathfrak{M},i})$ such that its cohomology groups, labeled ...
Bei, Francesco
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