Results 1 to 10 of about 13,444 (110)

PI(4,5)P2-dependent and -independent roles of PI4P in the control of hormone secretion by pituitary cells [PDF]

Frontiers in Endocrinology, 2023
Plasma membrane and organelle membranes are home to seven phosphoinositides, an important class of low-abundance anionic signaling lipids that contribute to cellular functions by recruiting cytoplasmic proteins or interacting with the cytoplasmic domains
Stanko S. Stojilkovic, Tamas Balla
doaj   +2 more sources

PI(4,5)P2 alleviates colitis by inhibiting intestinal epithelial cell pyroptosis through NNMT-mediated RBP4 m6A modification [PDF]

Cell Death and Disease
Lipid metabolism disorder is a critical feature of Crohn’s disease (CD). Phosphatidylinositol (PI) and its derivative, phosphatidylinositol bisphosphate (PIP2), are associated with CD. The mechanisms underlying such association remain unknown.
Qingfan Yang, Na Diao, Fei Ma, Zicheng Huang, Minzhi Lin, Xinyu Liu, Qin Guo, Pan Li, Jian Tang, Xiang Gao, Kang Chao   +10 more
doaj   +2 more sources

PI(4,5)P2 Imaging Using a GFP Reporter in Living Cells [PDF]

Bio-Protocol
Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is a phospholipid enriched on the cytoplasmic leaflet of the plasma membrane, where it plays important roles in membrane trafficking and cytoskeletal dynamics through proteins that directly bind to it. PI(
Mariam Alkandari, Christopher McMaster, Mahtab Tavasoli   +2 more
doaj   +2 more sources

Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy [PDF]

eLife
Anionic lipid molecules, including phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), are implicated in the regulation of epidermal growth factor receptor (EGFR).
Mitsuhiro Abe, Masataka Yanagawa, Michio Hiroshima, Toshihide Kobayashi, Yasushi Sako   +4 more
doaj   +2 more sources

Local PI(4,5)P2 synthesis by septin-associated PIPKIγ isoforms controls centralspindlin association with the midbody during cytokinesis [PDF]

Nature Communications
Cytokinesis critically depends on phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. Synthesis of PI(4,5)P2 is crucial for several stages of cytokinesis, including actomyosin ring assembly and constriction, membrane tethering of spindle microtubules, and
Giulia Russo, Nadja Hümpfer, Nina Jaensch, Steffen Restel, Christopher Schmied, Florian Heyd, Martin Lehmann, Helge Ewers, Volker Haucke, Michael Krauss   +9 more
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Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2 [PDF]

Nature Communications
Unconventional secretion of Fibroblast Growth Factor 2 (FGF2) is mediated by direct translocation across the plasma membrane. This process is initiated by PI(4,5)P2-dependent FGF2 oligomerization at the inner plasma membrane leaflet.
Manpreet Kaur, Fabio Lolicato, Walter Nickel   +2 more
doaj   +2 more sources

TPTE, a testis-specific PTEN family member, drives spermatogenesis via PI(4,5)P2 synthesis [PDF]

Cell Death and Disease
Phosphatidylinositol(4,5) bisphosphate (PI(4,5)P2) is the most abundant phosphoinositides species and plays regulatory roles in spermatogenesis. However, the role of the phosphatases that regulate the production of PI(4,5)P2 during spermatogenesis has ...
Xu Chen, Tianye Wang, Haiqian Wu, Xiangzheng Zhang, Hao Chen, Longsheng Zhang, Yan Zhu, Xingyu Zhang, Bing Wang, Yueshuai Guo, Chenghao Situ, Ying Zheng, Yan Li, Xuejiang Guo, Hui Zhu   +14 more
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A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8 [PDF]

Life Science Alliance, 2021
This study uncovers a critical role of DOCK8 in coupling PI(4,5)P2 signaling with Cdc42 activation through its DHR-1 domain during interstitial leukocyte migration.
Tetsuya Sakurai, Mutsuko Kukimoto-Niino, Kazufumi Kunimura, Nana Yamane, Daiji Sakata, Ryosuke Aihara, Tomoharu Yasuda, Shigeyuki Yokoyama, Mikako Shirouzu, Yoshinori Fukui, Takehito Uruno   +10 more
doaj   +2 more sources

The plasma membrane inner leaflet PI(4,5)P2 is essential for the activation of proton-activated chloride channels [PDF]

Nature Communications
Proton-activated chloride (PAC) channels, ubiquitously expressed in tissues, regulate intracellular Cl- levels and cell death following acidosis. However, molecular mechanisms and signaling pathways involved in PAC channel modulation are largely unknown.
Woori Ko, Euna Lee, Jung-Eun Kim, Hyun-Ho Lim, Byung-Chang Suh   +4 more
doaj   +2 more sources

Pictilisib and nutrient stress synergize to induce methuosis via PI(4,5)P2-dependent macropinocytic dysregulation in cancer cells [PDF]

Cell Death and Disease
Aberrant phosphatidylinositol 3-kinase (PI3K) activation drives many cancers, but PI3K inhibitors like Pictilisib often induce cytostasis rather than cytotoxicity, limiting their therapeutic potential.
Xuefei Wang, Xiaolin Sang, Yuemei Wen, Xingming Liao, Jiao Liu, Tiezheng Zheng, Tianming Xing, Min Wang, Dong An, Xining Zhang, Xiuling Li, Xinmiao Liang, Pixu Liu, Hailing Cheng   +13 more
doaj   +2 more sources