Results 41 to 50 of about 707,375 (141)
Scientific Reports, 2017 The metabolic processes of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] into PI(3,4,5)P3 and the subsequent PI(3,4,5)P3 signalling are involved in cell migration.
Satoshi Asano +7 more
doaj +1 more source
Investigation of HIV-1 Gag binding with RNAs and lipids using Atomic Force Microscopy.
PLoS ONE, 2020 Atomic Force Microscopy was utilized to study the morphology of Gag, ΨRNA, and their binding complexes with lipids in a solution environment with 0.1Å vertical and 1nm lateral resolution. TARpolyA RNA was used as a RNA control. The lipid used was phospha-
Shaolong Chen +6 more
doaj +1 more source
CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome
Advanced Science, EarlyView.By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen +11 more
wiley +1 more source
Ciliary Membrane Lipid Homeostasis in Health and Disease
Advanced Science, EarlyView.This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang +3 more
wiley +1 more source
Septin‐based readout of PI(4,5)P2 incorporation into membranes of giant unilamellar vesicles [PDF]
, 2018 International audienceSeptins constitute a novel class of cytoskeletal proteins. Budding yeast septins self-assemble into non-polar filaments bound to the inner plasma membrane through specific interactions with L-α-phosphatidylinositol-4,5-bisphosphate (
Daniel Lévy +15 more
core +1 more source
mBio, 2014 The matrix (MA) domain of HIV-1 mediates proper Gag localization and membrane binding via interaction with a plasma-membrane (PM)-specific acidic phospholipid, phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2].
Jingga Inlora +4 more
doaj +1 more source
Cholesterol Stimulates the Transient Receptor Potential Melastatin 4 Channel in mpkCCDc14 Cells
Frontiers in Pharmacology, 2021 We have shown that cholesterol regulates the activity of ion channels in mouse cortical collecting duct (CCD) mpkCCDc14 cells and that the transient receptor potential melastatin 4 (TRPM4) channel is expressed in these cells.
Yong-Xu Cai +14 more
doaj +1 more source
From Materials to Systems: Challenges and Solutions for Fast‐Charge/Discharge Na‐Ion Batteries
Advanced Energy Materials, EarlyView.This review systematically analyzes the key characteristics limiting the fast‐charge/discharge capability of Na‐ion batteries (SIBs) from a multi‐scale perspective encompassing electrode materials, the electrode‐electrolyte interface, and the system. Furthermore, it presents practical solution strategies for the fundamental issues arising at each scale,
Bonyoung Ku +5 more
wiley +1 more source
Model of PI(4,5)P2-ΨRNA-GagΔP6 interaction complex.
, 2020 Rough models of PI(4,5)P2-ΨRNA-GagΔP6 complexes based on the measured mean height and width. (a) Dimer complex, (b) Tetramer complex. MA domain is in red, CA domain is in yellow, NC domain is in green, ΨRNA is in cyan, and PI(4,5)P2 is in purple.
Umar Mohideen (8395047) +6 more
core +1 more source
Differential Regulation of Ca2+-Activated Cl− Channel TMEM16A Splice Variants by Membrane PI(4,5)P2 [PDF]
, 2021 TMEM16A is a Ca2+-activated Cl− channel that controls broad cellular processes ranging from mucus secretion to signal transduction and neuronal excitability.
Suh, Byung-Chang +3 more
core +1 more source