Targeting of MuLV Gag to the plasma membrane is mediated by PI(4,5)P and PhosphatidylSerine [PDF]
, 2009 Oral presentationInternational audienceMembrane targeting by the modern human immunodeficiency viruses is dependent on the plasma membrane-located phospholipid PI(4,5)P2.
Darlix, Jean-Luc +8 more
core +4 more sources
Regulation of actin dynamics by PI(4,5)P2 in cell migration and endocytosis [PDF]
Current Opinion in Cell Biology, 2019 The actin cytoskeleton is indispensable for several cellular processes, including migration, morphogenesis, polarized growth, endocytosis, and phagocytosis. The organization and dynamics of the actin cytoskeleton in these processes are regulated by Rho family small GTPases and kinase-phosphatase pathways.
Yosuke, Senju, Pekka, Lappalainen
openaire +2 more sources
Cell Reports, 2017 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) signaling is transient and spatially confined in live cells. How this pattern of signaling regulates transmitter release and hormone secretion has not been addressed. We devised an optogenetic approach to
Chen Ji, Fan Fan, Xuelin Lou
doaj +1 more source
A role for eisosomes in maintenance of plasma membrane phosphoinositide levels [PDF]
, 2014 The plasma membrane delineates the cell and mediates its communication and material exchange with the environment. Many processes of the plasma membrane occur through interactions of proteins with phosphatidylinositol(4,5)-bisphosphate (PI(4,5)P2), which
Alcazar-Roman, Abel +5 more
core +1 more source
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism
Cell Reports, 2019 Summary: Insulin stimulates the conversion of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) to phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), which mediates downstream cellular responses.
Diana G. Wang +14 more
doaj +1 more source
The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress [PDF]
, 2016 VP40 is one of eight proteins encoded by the Ebola Virus (EBOV) and serves as the primary matrix protein, forming virus like particles (VLPs) from mammalian cells without the need for other EBOV proteins.
Johnson, Kristen A. +3 more
core +1 more source
LPS-induced clustering of CD14 triggers generation of PI(4,5)P2 [PDF]
Journal of Cell Science, 2015 Bacterial lipopolysaccharide (LPS) induces strong pro-inflammatory reactions after sequential binding to CD14 protein and TLR4 receptor. Here we show that CD14 controls generation of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] in response to LPS binding. In J774 cells and HEK293 cells expressing CD14 exposed to 10-100 ng/ml LPS, the level of PI(4,
Agnieszka, Płóciennikowska +4 more
openaire +2 more sources
Modulation of KV7 Channel Deactivation by PI(4,5)P2 [PDF]
Frontiers in Pharmacology, 2020 The activity of KV7 channels critically contributes to the regulation of cellular electrical excitability in many cell types. In the central nervous system, the heteromeric KV7.2/KV7.3 channel is thought to be the chief molecular entity giving rise to M-currents.
openaire +3 more sources
New Experimental Trends for Phosphoinositides Research on Ion Transporter/Channel Regulation
Journal of Pharmacological Sciences, 2014 .: Phosphoinositides(4,5)-bisphosphates [PI(4,5)P2] critically controls membrane excitability, the disruption of which leads to pathophysiological states.
Masayuki X. Mori, Ryuji Inoue
doaj +1 more source
Optogenetic dephosphorylation of phosphatidylinositol 4,5 bisphosphate in Xenopus laevis oocytes
STAR Protocols, 2023 Summary: Here, we present a protocol for optogenetic dephosphorylation of the phosphoinositide PI(4,5)P2 at the plasma membrane of Xenopus laevis oocytes. We first describe the co-injection of oocytes with cRNAs encoding (1) a light-activated PI(4,5)P2 5-
Kirin D. Gada +6 more
doaj +1 more source