The Inositol 5-Phosphatase dOCRL Controls PI(4,5)P2 Homeostasis and Is Necessary for Cytokinesis [PDF]
, 2011 SummaryDuring cytokinesis, constriction of an equatorial actomyosin ring physically separates the two daughter cells. At the cleavage furrow, the phosphoinositide PI(4,5)P2 plays an important role by recruiting and regulating essential proteins of the ...
Amin A +13 more
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Regulation of voltage-gated potassium channels by PI(4,5)P2 [PDF]
Journal of General Physiology, 2012 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) regulates activities of numerous ion channels including inwardly rectifying potassium (Kir) channels, KCNQ, TRP, and voltage-gated calcium channels. Several studies suggest that voltage-gated potassium (KV) channels might be regulated by PI(4,5)P2.
Kruse, Martin +2 more
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Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector [PDF]
, 2012 Adaptive immunity depends on lymphocyte adhesion that is mediated by the integrin lymphocyte functional antigen 1 (LFA-1). The small guanosine triphosphatase Rap1 regulates LFA-1 adhesiveness through one of its effectors, Rap1-interacting adapter ...
Boussiotis, Vassiliki A. +7 more
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Distinct functional properties of two electrogenic isoforms of the SLC34 Na‐Pi cotransporter
Physiological Reports, 2019 Inorganic phosphate (Pi) is crucial for proper cellular function in all organisms. In mammals, type II Na‐Pi cotransporters encoded by members of the Slc34 gene family play major roles in the maintenance of Pi homeostasis.
Natsuki Mizutani +2 more
doaj +1 more source
Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring
eLife, 2017 HIV-1 assembles at the plasma membrane (PM) of infected cells. PM association of the main structural protein Gag depends on its myristoylated MA domain and PM PI(4,5)P2. Using a novel chemical biology tool that allows rapidly tunable manipulation of PI(4,
Frauke Mücksch +4 more
doaj +1 more source
Structural organization and dynamics of FCHo2 docking on membranes
eLife, 2022 Clathrin-mediated endocytosis (CME) is a central trafficking pathway in eukaryotic cells regulated by phosphoinositides. The plasma membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) plays an instrumental role in driving CME initiation. The F-BAR
Fatima El Alaoui +11 more
doaj +1 more source
Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer [PDF]
, 2015 In the absence of extracellular stimulation the adaptor protein growth factor receptor-bound protein (Grb2) and the phospholipase Plcγ1 compete for the same binding site on fibroblast growth factor receptor 2 (FGFR2).
A B Gladden +64 more
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The Molecular Determinants of PI(4,5)P2 Binding to TRPV1 Channels [PDF]
Biophysical Journal, 2015 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) has been recognized as an important activator of certain transient receptor potential (TRP) channels. More specifically, TRPV1 is a pain receptor activated by a wide range of stimuli. However, whether or not PI(4,5)P2 is a TRPV1 agonist remains open to debate.
Poblete, Horacio +9 more
openaire +1 more source
Local PI(4,5)P2 signaling inhibits fusion pore expansion during exocytosis
Cell Reports, 2023 Summary: Phosphatidylinositol(4,5)bisphosphate (PI(4,5)P2) is an important signaling phospholipid that is required for regulated exocytosis and some forms of endocytosis.
Muhmmad Omar-Hmeadi +2 more
doaj +1 more source
Phosphatidylinositol 4-phosphate 5-kinase β regulates growth cone morphology and Semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons [PDF]
, 2013 Growth cone motility and morphology, which are critical for axon guidance, are controlled through intracellular events such as actin cytoskeletal reorganization and vesicular trafficking.
Goshima Yoshio +4 more
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