Results 61 to 70 of about 62,994 (190)
The coincidence biosensor tubbyCT reveals local phosphatidylinositol-4,5-bisphosphate synthesis at endoplasmic reticulum-plasma membrane junctions [PDF]
, 2020 Phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) plays a prominent role in plasma membrane (PM) physiology. It is implicated in the regulation of a variety of cellular functions including exo- and endocytosis, cytoskeleton anchorage, and ion channel ...
Thallmair, Veronika
core +1 more source
Frontiers in Pharmacology, 2015 Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4 ...
Masayuki X Mori +6 more
doaj +1 more source
Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. [PDF]
, 2014 The exocyst serves to tether secretory vesicles to cortical sites specified by polarity determinants, in preparation for fusion with the plasma membrane.
Liu, Dongmei, Novick, Peter
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Quantification of the in-vivo affinity of PI(4,5)P2 effectors and sensors with the phosphoinositide phosphatase Ci-VSP [PDF]
, 2011 Zusammenfassung Quantifizierung der in-vivo Affinität von PI(4,5)P2- Effektoren und Sensoren mit der Phosphoinositidphosphatase Ci-VSP Phosphoinositide (PI) sind Mitglieder einer Familie kleiner Membranphospholipide, die wichtige Aufgaben in vielen ...
Rjasanow, Alexandra
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Competitive Interactions of PIRT and PI(4,5)P2 Modulate TRPM8 [PDF]
Biophysical Journal, 2017 PIRT or Phosphoinositide regulator of TRP is a small membrane protein that has been shown to modulate the function of TRP channels. PIRT is implicated in fine-tuning the physiological roles that TRP channels play in thermosensing and ligand activation; suggesting roles for PIRT:TRP complexes in pathophysiologies such as pruritus and chronic pain. In an
Nicholas Sisco +4 more
openaire +1 more source
Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms
Journal of Lipid Research, 2007 Previously, ceramide-1-phosphate (C1P) and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] were demonstrated to be potent and specific activators of group IVA cytosolic phospholipase A2 (cPLA2α). In this study, we hypothesized that these anionic lipids
Preeti Subramanian +4 more
doaj +1 more source
The roles of lipids and nucleic acids in HIV-1 assembly [PDF]
, 2014 During HIV-1 assembly, precursor Gag (PrGag) proteins are delivered to plasma membrane (PM) assembly sites, where they are triggered to oligomerize and bud from cells as immature virus particles.
Ayna Alfadhli, Eric Barklis
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Competitive PIRT and PI(4,5)P2 Interactions Modulate TRPM8 [PDF]
Biophysical Journal, 2016 Phosphoinositide regulator of TRP (PIRT) is a small human membrane protein that has been shown to modulate the function of specific TRP channels. PIRT has been implicated in fine-tuning the roles that TRP channels play in thermosensing, ligand activation, and pruritus.
Sisco, Nicholas J. +2 more
openaire +1 more source
Biology, 2021 TREK-2-like channels in the pyramidal neurons of rat prefrontal cortex are characterized by a wide range of spontaneous activity—from very low to very high—independent of the membrane potential and the stimuli that are known to activate TREK-2 channels ...
Beata Dworakowska +2 more
doaj +1 more source
Septin‐based readout of PI(4,5)P2 incorporation into membranes of giant unilamellar vesicles [PDF]
, 2018 International audienceSeptins constitute a novel class of cytoskeletal proteins. Budding yeast septins self-assemble into non-polar filaments bound to the inner plasma membrane through specific interactions with L-α-phosphatidylinositol-4,5-bisphosphate (
Alqabandi, Maryam +7 more
core +1 more source