Results 1 to 10 of about 29,762 (206)
Electrostatic regulation of the cis- and trans-membrane interactions of synaptotagmin-1
Scientific Reports, 2022 Synaptotagmin-1 is a vesicular protein and Ca2+ sensor for Ca2+-dependent exocytosis. Ca2+ induces synaptotagmin-1 binding to its own vesicle membrane, called the cis-interaction, thus preventing the trans-interaction of synaptotagmin-1 to the plasma ...
Houda Yasmine Ali Moussa, Yongsoo Park
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eLife, 2020 The Ca2+ sensor synaptotagmin-1 and the SNARE complex cooperate to trigger neurotransmitter release. Structural studies elucidated three distinct synaptotagmin-1-SNARE complex binding modes involving ‘polybasic’, ‘primary’ and ‘tripartite’ interfaces of ...
Rashmi Voleti +2 more
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eLife, 2021 Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca2 ...
Bassam Tawfik +8 more
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eLife, 2022 Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon Ca2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes between the vesicle and plasma membranes that are bound to Synaptotagmin-1 ...
Josep Rizo +4 more
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The Role of Calmodulin vs. Synaptotagmin in Exocytosis
Frontiers in Molecular Neuroscience, 2021 Exocytosis is a Ca2+-regulated process that requires the participation of Ca2+ sensors. In the 1980s, two classes of Ca2+-binding proteins were proposed as putative Ca2+ sensors: EF-hand protein calmodulin, and the C2 domain protein synaptotagmin. In the
Renhao Xue +8 more
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Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release
eLife, 2020 Dopamine powerfully controls neural circuits through neuromodulation. In the vertebrate striatum, dopamine adjusts cellular functions to regulate behaviors across broad time scales, but how the dopamine secretory system is built to support fast and slow ...
Aditi Banerjee +4 more
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Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
eLife, 2020 Calcium (Ca2+)-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca2+-influx. The principal components involved in these processes are
Sathish Ramakrishnan +4 more
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Guiding AlphaFold to predict how Munc13-1 opens Syntaxin-1. [PDF]
FEBS Open BioThe syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Chattopadhyay M, Xu J, Rizo J.
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Synaptotagmin: Mechanisms of an electrostatic switch
Neuroscience Letters, 2020 Synaptic transmission relies on the fast, synchronous fusion of neurotransmitter filled vesicles with the presynaptic membrane. Synaptotagmin is the Ca2+ sensor that couples the Ca2+ influx into nerve terminals following an action potential with this ...
Noreen Reist, Matthew R Bowers
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Neuron, 2017 Summary Synaptic vesicle recycling is essential for maintaining normal synaptic function. The coupling of exocytosis and endocytosis is assumed to be Ca2+-dependent but the exact role of Ca2+ and its key effector synaptotagmin-1 (syt1) in regulation of ...
Natalí L. Chanaday +2 more
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