Results 1 to 10 of about 35,245 (228)

Synaptotagmin-7 is an asynchronous calcium sensor for synaptic transmission in neurons expressing SNAP-23. [PDF]

PLoS ONE, 2014
Synchronization of neurotransmitter release with the presynaptic action potential is essential for maintaining fidelity of information transfer in the central nervous system.
Jens P Weber, Trine L Toft-Bertelsen, Ralf Mohrmann, Ignacio Delgado-Martinez, Jakob B Sørensen   +4 more
doaj   +7 more sources

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion [PDF]

eLife, 2012
The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Jiajie Diao, Patricia Grob, Daniel J Cipriano, Minjoung Kyoung, Yunxiang Zhang, Sachi Shah, Amie Nguyen, Mark Padolina, Ankita Srivastava, Marija Vrljic, Ankita Shah, Eva Nogales, Steven Chu, Axel T Brunger   +13 more
doaj   +3 more sources

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Gilligan M, Mills JR, Vargas P, Paramasivan NK, Lesnick CE, Basal E, Dasari S, Fryer JP, Hinson SR, Laporta J, Espinal A, Fitzgerald D, Garcia C, Morenkova AE, Pergami P, Shah A, Knight A, LaFrance Corey R, Lennon VA, Zekeridou A, Pittock SJ, Dubey D, McKeon A.   +22 more
europepmc   +2 more sources

Minimal presynaptic protein machinery governing diverse kinetics of calcium-evoked neurotransmitter release [PDF]

Nature Communications
Neurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic calcium influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of activity.
Dipayan Bose, Manindra Bera, Christopher A. Norman, Yulia Timofeeva, Kirill E. Volynski, Shyam S. Krishnakumar   +5 more
doaj   +2 more sources

Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]

, 2012
Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
A Lux, AK Berntson, AK Steck, B Wiggert, Barbara Amann, BD McNeil, BM Spiess, C Eberhardt, C Kiel, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CM Kalsow, Cornelia A. Deeg, CW Morgans, D Josic, D Schubert, ER Chapman, G Glavan, H de Wit, Hassan Y. Naim, HY Naim, J Petersen, J Ratelade, JK Zipplies, JP Collin, JW Becker, K Marino, KF Greif, KS Shamsi, LN Troelsen, Lucienne Chatenoud, M Mirshahi, M Takamori, M Takamori, M Takamori, M Takamori, M Vrljic, M Zhao, MA Koontz, Margarete E. Swadzba, MC Ehrenhofer, MC Kwok, MC Papadopoulos, ME Swadzba, MJ Lewis, N Martin-Moutot, P Ariel, P David, P Redecker, RA Levy, RL Degroote, RR Caspi, S Bohm, SM Hauck, SM Hauck, Stefanie M. Hauck, V Gauba, VA Lennon, VA Lennon, W Han, W Vennekate, XQ Liu, Y Wang   +68 more
core   +13 more sources

Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming

eLife, 2021
Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca2 ...
Bassam Tawfik, Joana S Martins, Sébastien Houy, Cordelia Imig, Paulo S Pinheiro, Sonja M Wojcik, Nils Brose, Benjamin H Cooper, Jakob Balslev Sørensen   +8 more
doaj   +1 more source

Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. [PDF]

PLoS ONE, 2010
Synaptotagmins are known to mediate diverse forms of Ca2+-triggered exocytosis through their C2 domains, but the principles underlying functional differentiation among them are unclear.
Mingshan Xue, Timothy K Craig, Ok-Ho Shin, Liyi Li, Chad A Brautigam, Diana R Tomchick, Thomas C Südhof, Christian Rosenmund, Josep Rizo   +8 more
doaj   +1 more source

Electrostatic regulation of the cis- and trans-membrane interactions of synaptotagmin-1

Scientific Reports, 2022
Synaptotagmin-1 is a vesicular protein and Ca2+ sensor for Ca2+-dependent exocytosis. Ca2+ induces synaptotagmin-1 binding to its own vesicle membrane, called the cis-interaction, thus preventing the trans-interaction of synaptotagmin-1 to the plasma ...
Houda Yasmine Ali Moussa, Yongsoo Park
doaj   +1 more source

Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration

Nature Communications, 2023
Synaptotagmin-1 and synaptotagmin-7 are two prominent calcium sensors that regulate exocytosis in neuronal and neuroendocrine cells. Upon binding calcium, both proteins partially penetrate lipid bilayers that bear anionic phospholipids, but the specific ...
Kevin C. Courtney, Taraknath Mandal, Nikunj Mehta, Lanxi Wu, Yueqi Li, Debasis Das, Qiang Cui, Edwin R. Chapman   +7 more
doaj   +1 more source

Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes

eLife, 2020
The Ca2+ sensor synaptotagmin-1 and the SNARE complex cooperate to trigger neurotransmitter release. Structural studies elucidated three distinct synaptotagmin-1-SNARE complex binding modes involving ‘polybasic’, ‘primary’ and ‘tripartite’ interfaces of ...
Rashmi Voleti, Klaudia Jaczynska, Josep Rizo   +2 more
doaj   +1 more source