Results 1 to 10 of about 195,241 (153)
Genetic disorders of neurotransmitter release machinery [PDF]
Frontiers in Synaptic Neuroscience, 2023 Synaptic neurotransmitter release is an evolutionarily conserved process that mediates rapid information transfer between neurons as well as several peripheral tissues.
Burak Uzay +3 more
doaj +2 more sources
The self regulation of neurotransmitter release [PDF]
Frontiers in Cellular Neuroscience, 2014 Retzius cells are large neurons in the ganglia of the leech (Lent, 1977), releasing 5-HT (Leake, 1986) and orchestrating the animal behavior (Carretta, 1988). The leech nervous system is relatively simple and its exploration allows correlating, in a quantitative manner, the chemical and electrical activity, at cellular level, with the animal behavior ...
Marco eCanepari, Marco eCanepari
doaj +4 more sources
Strikingly different neurotransmitter release strategies in dopaminergic subclasses [PDF]
eLifeNeuronal function is intimately tied to axodendritic polarity. Neurotransmitter release, for example, is usually the role of the axon. There are widespread exceptions to this rule, however, including many mammalian neuronal types that can release ...
Ana Dorrego-Rivas +7 more
doaj +3 more sources
Microtubule depolymerization contributes to spontaneous neurotransmitter release in vitro [PDF]
Communications Biology, 2023 Microtubules are key to multiple neuronal functions involving the transport of organelles, however, their relationship to neurotransmitter release is still unresolved.
Cecilia D. Velasco +5 more
doaj +2 more sources
Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions [PDF]
Nature CommunicationsIn the pre-synapse, vesicle fusion is a crucial process for neurotransmitter release in the nervous system. Under physiological conditions, synaptotagmin-1 (Syt1) locks synaptic vesicles in a priming state, allowing them to undergo synchronized ...
Yijuan Xiang +13 more
doaj +2 more sources
AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release [PDF]
Frontiers in Molecular Neuroscience, 2023 Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses.
Harrison J. Ramsay +9 more
doaj +2 more sources
The role of RIM in neurotransmitter release: promotion of synaptic vesicle docking, priming, and fusion [PDF]
Frontiers in Neuroscience, 2023 There are many special sites at the end of a synapse called active zones (AZs). Synaptic vesicles (SVs) fuse with presynaptic membranes at these sites, and this fusion is an important step in neurotransmitter release.
Shanshan Wu +13 more
doaj +2 more sources
Stochastic RNA editing of the Complexin C-terminus within single neurons regulates neurotransmitter release [PDF]
Cell Reports, 2023 Summary: Neurotransmitter release requires assembly of the SNARE complex fusion machinery, with multiple SNARE-binding proteins regulating when and where synaptic vesicle fusion occurs.
Elizabeth A. Brija +3 more
doaj +2 more sources
Journal of Pharmacological Sciences, 2003 : Synaptic transmission is conducted by neurotransmitters released from nerve terminals. Neurotransmitter release is regulated both positively and negatively by multiple mechanisms, and its regulation is believed to be one of the important mechanisms of ...
Masami Takahashi +2 more
doaj +3 more sources
Cell Calcium, 2008 Neurotransmitter release from neurons takes place at specialized structures called synapses. Action potential-evoked exocytosis requires Ca(2+) influx through voltage-gated Ca(2+) channels. Spontaneous vesicle fusion occurs both in the absence of action potentials and without any apparent stimulus and is hence thought to be Ca(2+)-independent. However,
Maike Glitsch
exaly +3 more sources