Results 1 to 10 of about 292,316 (294)

Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon

eLife, 2018
Light-gated chloride channels are emerging as promising optogenetic tools for inhibition of neural activity. However, their effects depend on the transmembrane chloride electrochemical gradient and may be complex due to the heterogeneity of this gradient
Jessica E Messier, Hongmei Chen, Zhao-Lin Cai, Mingshan Xue   +3 more
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Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse

Frontiers in Molecular Neuroscience
IntroductionRecently developed fluorescent neurotransmitter indicators have enabled direct measurements of neurotransmitter in the synaptic cleft. Precise optical measurements of neurotransmitter release may be used to make inferences about presynaptic ...
Paul Jakob Habakuk Hain, Paul Jakob Habakuk Hain, Tobias Moser, Tobias Moser   +3 more
doaj   +1 more source

Spontaneous neurotransmitter release and Ca2+—How spontaneous is spontaneous neurotransmitter release?

Cell Calcium, 2008
Neurotransmitter release from neurons takes place at specialized structures called synapses. Action potential-evoked exocytosis requires Ca(2+) influx through voltage-gated Ca(2+) channels. Spontaneous vesicle fusion occurs both in the absence of action potentials and without any apparent stimulus and is hence thought to be Ca(2+)-independent. However,
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Neurotransmitter Release at Central Synapses [PDF]

Neuron, 2003
Our understanding of synaptic transmission has grown dramatically during the 15 years since the first issue of Neuron was published, a growth rate expected from the rapid progress in modern biology. As in all of biology, new techniques have led to major advances in the cell and molecular biology of synapses, and the subject has evolved in ways (like ...
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Membrane bridging by Munc13-1 is crucial for neurotransmitter release

eLife, 2019
Munc13-1 plays a crucial role in neurotransmitter release. We recently proposed that the C-terminal region encompassing the C1, C2B, MUN and C2C domains of Munc13-1 (C1C2BMUNC2C) bridges the synaptic vesicle and plasma membranes through interactions ...
Bradley Quade, Marcial Camacho, Xiaowei Zhao, Marta Orlando, Thorsten Trimbuch, Junjie Xu, Wei Li, Daniela Nicastro, Christian Rosenmund, Josep Rizo   +9 more
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Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner

eLife, 2020
Synchronous neurotransmitter release is triggered by Ca2+ binding to the synaptic vesicle protein Synaptotagmin 1, while asynchronous fusion and short-term facilitation is hypothesized to be mediated by plasma membrane-localized Synaptotagmin 7 (SYT7 ...
Zhuo Guan, Monica C Quiñones-Frías, Yulia Akbergenova, J Troy Littleton   +3 more
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Genome-Wide Association Study Identifies Genomic Loci Associated With Neurotransmitter Concentration in Cattle

Frontiers in Genetics, 2020
Abnormal neurotransmitter concentration is one of the factors that affect the health status, behavioral personality, and welfare level of animals, but the genetic basis of the abnormality is still largely unknown.
Qiuming Chen, Kaixing Qu, Zhijie Ma, Jingxi Zhan, Fengwei Zhang, Jiafei Shen, Qingqing Ning, Peng Jia, Jicai Zhang, Ningbo Chen, Hong Chen, Bizhi Huang, Chuzhao Lei   +12 more
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Calcium Control of Neurotransmitter Release [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Upon entering a presynaptic terminal, an action potential opens Ca(2+) channels, and transiently increases the local Ca(2+) concentration at the presynaptic active zone. Ca(2+) then triggers neurotransmitter release within a few hundred microseconds by activating synaptotagmins Ca(2+). Synaptotagmins bind Ca(2+) via two C2-domains, and transduce the Ca(
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HDAC6 Is a Bruchpilot Deacetylase that Facilitates Neurotransmitter Release

Cell Reports, 2014
Presynaptic densities are specialized structures involved in synaptic vesicle tethering and neurotransmission; however, the mechanisms regulating their function remain understudied.
Katarzyna Miskiewicz, Liya E. Jose, Wondwossen M. Yeshaw, Jorge S. Valadas, Jef Swerts, Sebastian Munck, Fabian Feiguin, Bart Dermaut, Patrik Verstreken   +8 more
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Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3

Frontiers in Synaptic Neuroscience, 2015
The identity of the vesicle neurotransmitter transporter expressed by a neuron largely corresponds with the primary neurotransmitter that cell releases.
Johannes eZimmermann, Melissa eHerman, Christian eRosenmund   +2 more
doaj   +1 more source