Results 21 to 30 of about 1,558,949 (288)

The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression

eLife, 2022
Synaptic proteins and synaptic transmission are under homeostatic control, but the relationship between these two processes remains enigmatic. Here, we systematically investigated the role of E3 ubiquitin ligases, key regulators of protein degradation ...
Martin Baccino-Calace, Katharina Schmidt, Martin Müller   +2 more
doaj   +1 more source

The role of the C2A domain of synaptotagmin 1 in asynchronous neurotransmitter release.

PLoS ONE, 2020
Following nerve stimulation, there are two distinct phases of Ca2+-dependent neurotransmitter release: a fast, synchronous release phase, and a prolonged, asynchronous release phase.
Mallory C Shields, Matthew R Bowers, Hannah L Kramer, McKenzie M Fulcer, Lara C Perinet, Marissa J Metz, Noreen E Reist   +6 more
doaj   +1 more source

Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact

Nature Communications, 2021
Synaptotagmin 1 (Syt1) is the calcium sensor for fast synchronous neurotransmitter release but the mechanism by which it functions is still under debate.
Sarah B. Nyenhuis, Nakul Karandikar, Volker Kiessling, Alex J. B. Kreutzberger, Anusa Thapa, Binyong Liang, Lukas K. Tamm, David S. Cafiso   +7 more
doaj   +1 more source

The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]

, 2011
The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Boris P. Klyuch, Mark J. Wall, Richardson, Magnus J. E., Klyuch, Boris P., Dale, Nicholas, Magnus J. E. Richardson, Wall, Mark J., Nicholas Dale   +7 more
core   +1 more source

Dataset associated with "The role of the C2A domain of synaptotagmin 1 in asynchronous neurotransmitter release"

, 2020
This dataset includes all raw data for experiments included in the manuscript. It also includes raw, unedited microscopy and blot images.Following nerve stimulation, there are two distinct phases of Ca2+-dependent neurotransmitter release: a fast ...
Bowers, Matthew, Metz, Marissa, Shields, Mallory, Perinet, Lara, Reist, Noreen, Kramer, Hannah, Fulcer, McKenzie   +6 more
core   +1 more source

The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings [PDF]

, 1992
The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland.
Weller, U., Nordmann, J. J., Dayanithi, G., Ahnert-Hilger, G., Lnk, H., Gratzl, Manfred   +5 more
core   +1 more source

Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2. [PDF]

, 2012
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42).
Russell, CL, Claire L Russell, Beesley, PW, Sophia Semerdjieva, Ruth M Empson, Semerdjieva Sophia, Brian M Austen, Empson, RM, Austen Brian M., Empson Ruth M., Russell Claire L., Philip W Beesley, Alifragis Pavlos, Beesley Philip W., Semerdjieva, S, Alifragis, P, Pavlos Alifragis, Austen, BM   +17 more
core   +2 more sources

Long-term plasticity determines the postsynaptic response to correlated afferents with multivesicular short-term synaptic depression

Frontiers in Computational Neuroscience, 2014
Synchrony in a presynaptic population leads to correlations in vesicle occupancy at the active sites for neurotransmitter release. The number of independent release sites per presynaptic neuron, a synaptic parameter recently shown to be modifed during ...
Alexander David Bird, Alexander David Bird, Magnus J E Richardson   +2 more
doaj   +1 more source

Renin-Angiotensin System and Sympathetic Neurotransmitter Release in the Central Nervous System of Hypertension

International Journal of Hypertension, 2012
Many Studies suggest that changes in sympathetic nerve activity in the central nervous system might have a crucial role in blood pressure control. The present paper discusses evidence in support of the concept that the brain renin-angiotensin system (RAS)
Kazushi Tsuda
doaj   +1 more source

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

eLife, 2019
All synapses require fusion-competent vesicles and coordinated Ca2+-secretion coupling for neurotransmission, yet functional and anatomical properties are diverse across different synapse types.
Marisa M Brockmann, Marta Maglione, Claudia G Willmes, Alexander Stumpf, Boris A Bouazza, Laura M Velasquez, M Katharina Grauel, Prateep Beed, Martin Lehmann, Niclas Gimber, Jan Schmoranzer, Stephan J Sigrist, Christian Rosenmund, Dietmar Schmitz   +13 more
doaj   +1 more source