Biological roles of plant synaptotagmins
European Journal of Cell Biology, 2023 Plant synaptotagmins (SYTs) are resident proteins of the endoplasmic reticulum (ER). They are characterized by an N-terminal transmembrane region and C2 domains at the C-terminus, which tether the ER to the plasma membrane (PM).
Francisco Benitez-Fuente
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The Extended Synaptotagmins of Physcomitrium patens [PDF]
PlantsMembrane contact sites (MCSs) between the endoplasmic reticulum and the plasma membrane enable the transport of lipids without membrane fusion. Extended Synaptotagmins (ESYTs) act at MCSs, functioning as tethers between two membrane compartments.
Alexander Kaier, Maria Ntefidou
doaj +5 more sources
Ring-like oligomers of Synaptotagmins and related C2 domain proteins [PDF]
eLife, 2016 We recently reported that the C2AB portion of Synaptotagmin 1 (Syt1) could self-assemble into Ca2+-sensitive ring-like oligomers on membranes, which could potentially regulate neurotransmitter release.
Maria N Zanetti +7 more
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SYNAPTOTAGMIN 4 is expressed mainly in the phloem and participates in abiotic stress tolerance in Arabidopsis [PDF]
Frontiers in Plant SciencePlant synaptotagmins structurally resemble animal synaptotagmins and extended-synaptotagmins. Animal synaptotagmins are well-characterized calcium sensors in membrane trafficking, and extended-synaptotagmins mediate lipid transfer at the endoplasmic ...
Ajay Kumar +2 more
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Alterations in the proteomic profiles of Arabidopsis roots triggered by sodium chloride stress are exacerbated by impaired function of SYNAPTOTAGMIN 1 [PDF]
BMC Plant BiologyPlant synaptotagmins, especially SYT1, are involved in responses to different environmental stressors. We revealed that SYT1 abundance at the cell periphery in Arabidopsis roots and its turnover decelerated upon salt stress. Results of proteomic analysis
Zuzana Kusá +9 more
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Ca2+-dependent vesicular and non-vesicular lipid transfer controls hypoosmotic plasma membrane expansion [PDF]
BMC BiologyBackground Robust coordination of surface and volume changes is critical for cell integrity. Few studies have elucidated the plasma membrane (PM) remodeling events during drastic cell surface and volume alteration, especially regarding PM sensing and its
Baicong Mu +4 more
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Dual-Ring SNAREpin Machinery Tuning for Fast Synaptic Vesicle Fusion [PDF]
BiomoleculesDuring neurotransmission, neurotransmitters are released less than a millisecond after the arrival of the action potential. To achieve this ultra-fast event, the synaptic vesicle must be pre-docked to the plasma membrane. In this primed state, SNAREpins,
Matthieu Caruel, Frédéric Pincet
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A high-performance GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release [PDF]
Nature CommunicationsThe co-existence and co-transmission of neuropeptides and small molecule neurotransmitters within individual neuron represent a fundamental characteristic observed across various species.
Xiju Xia, Yulong Li
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Summing across different active zones can explain the quasi-linear Ca2+-dependencies of exocytosis by receptor cells [PDF]
Frontiers in Synaptic Neuroscience, 2010 Several recent studies of mature auditory and vestibular hair cells, and of visual and olfactory receptor cells, have observed nearly linear dependencies of the rate of neurotransmitter release events, or related measures, on the magnitude of Ca2+-entry ...
Peter Heil, Heinrich Neubauer
doaj +3 more sources
Calcium-sensitive synaptotagmin 11-lipid interaction modulates exo-endocytosis [PDF]
Nature CommunicationsSynaptotagmins (Syts) are the primary Ca2+-sensors for synaptic vesicle exocytosis, while most mammalian Syts are non-Ca2+-affinitive and play critical roles in neurotransmission and synaptic plasticity with unclear mechanisms.
Xuanang Wu +17 more
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