Results 31 to 40 of about 4,005 (212)

The Arabidopsis Synaptotagmin1 is enriched in endoplasmic reticulum-plasma membrane contact sites and confers cellular resistance to mechanical stresses [PDF]

, 2015
Eukaryotic endoplasmic reticulum (ER)-plasma membrane (PM) contact sites are evolutionarily conserved microdomains that have important roles in specialized metabolic functions such as ER-PM communication, lipid homeostasis, and Ca2+ influx.
Botella, Miguel A, Esteban del Valle, Alicia, Friml, Jiri, Lee, Eunkyoung, McFarlane, Heather E, Pérez-Sancho, Jessica, Rosado, Abel, Valpuesta, Victoriano, Vanneste, Steffen   +8 more
core   +2 more sources

Synaptotagmin gene content of the sequenced genomes

BMC Genomics, 2004
Background Synaptotagmins exist as a large gene family in mammals. There is much interest in the function of certain family members which act crucially in the regulated synaptic vesicle exocytosis required for efficient neurotransmission.
Craxton Molly
doaj   +1 more source

Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes. [PDF]

PLoS ONE, 2014
Extended synaptotagmins (E-Syts) are a recently identified family of proteins that tether the endoplasmic reticulum (ER) to the plasma membrane (PM) in part by conferring regulation of cytosolic calcium (Ca2+) at these contact sites (Cell, 2013). However,
Maria Jimena Amaya, André G Oliveira, Lena K Schroeder, Edward S Allgeyer, Joerg Bewersdorf, Michael H Nathanson   +5 more
doaj   +1 more source

MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity. [PDF]

, 2017
Presynaptic homeostatic plasticity (PHP) controls synaptic transmission in organisms from Drosophila to human and is hypothesized to be relevant to the cause of human disease.
Davis, Graeme W, Dickman, Dion K, Fetter, Richard D, Genç, Özgür, Ma, Wenpei, Tong, Amy   +5 more
core   +2 more sources

How Synaptotagmin Promotes Membrane Fusion [PDF]

Science, 2007
Synaptic vesicles loaded with neurotransmitters are exocytosed in a soluble N -ethylmaleimide–sensitive factor attachment protein receptor (SNARE)–dependent manner after presynaptic depolarization induces calcium ion (Ca 2+ ) influx. The Ca
Martens, Sascha, Kozlov, Michael M, McMahon, Harvey T   +2 more
openaire   +2 more sources

Peptidergic cell-specific synaptotagmins in Drosophila: Localization to dense-core granules and regulation by the bHLH protein dimmed [PDF]

, 2014
Bioactive peptides are packaged in large dense-core secretory vesicles, which mediate regulated secretion by exocytosis. In a variety of tissues, the regulated release of neurotransmitters and hormones is dependent on calcium levels and controlled by ...
Dani, Adish, Li, Peiyao, Park, Dongkook, Taghert, Paul H   +3 more
core   +2 more sources

Identification of a novel protein containing two C2 domains selectively expressed in the rat brain and kidney [PDF]

, 1996
We have isolated and characterized a rat brain cDNA clone which encodes a new protein of 474 amino acids in length which contains two C2 domains structurally homologous to those present in synaptotagmins.
Bos, Lieuwe D., Cremer, Olaf L., MARS consortium, Ong, David S Y, Schouten, Laura R., Schultz, Marcus J.   +5 more
core   +4 more sources

Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]

, 2012
Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
A Lux, AK Berntson, AK Steck, B Wiggert, Barbara Amann, BD McNeil, BM Spiess, C Eberhardt, C Kiel, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CM Kalsow, Cornelia A. Deeg, CW Morgans, D Josic, D Schubert, ER Chapman, G Glavan, H de Wit, Hassan Y. Naim, HY Naim, J Petersen, J Ratelade, JK Zipplies, JP Collin, JW Becker, K Marino, KF Greif, KS Shamsi, LN Troelsen, Lucienne Chatenoud, M Mirshahi, M Takamori, M Takamori, M Takamori, M Takamori, M Vrljic, M Zhao, MA Koontz, Margarete E. Swadzba, MC Ehrenhofer, MC Kwok, MC Papadopoulos, ME Swadzba, MJ Lewis, N Martin-Moutot, P Ariel, P David, P Redecker, RA Levy, RL Degroote, RR Caspi, S Bohm, SM Hauck, SM Hauck, Stefanie M. Hauck, V Gauba, VA Lennon, VA Lennon, W Han, W Vennekate, XQ Liu, Y Wang   +68 more
core   +11 more sources

Synaptotagmin II. A novel differentially distributed form of synaptotagmin

Journal of Biological Chemistry, 1991
Synaptotagmin is a synaptic vesicle membrane protein with properties suggestive of a role in synaptic vesicle exocytosis (Perin, M. S., Fried, V. A., Mignery, G. A., Jahn, R., and Südhof, T. C. (1990) Nature 345, 260-263). Here, we report the structure of a novel form of synaptotagmin named synaptotagmin II that is highly homologous to the originally ...
M, Geppert, B T, Archer, T C, Südhof
openaire   +2 more sources

Synaptotagmin 13: Structure and expression of a novel synaptotagmin

European Journal of Cell Biology, 2001
Synaptotagmins represent a family of putative vesicular trafficking proteins. With synaptotagmin 13, we have now identified a novel synaptotagmin, making this one of the largest families of trafficking proteins. Similar to synaptotagmins 3, 4, 6, 7, 9, and 11, synaptotagmin 13 is expressed at highest levels in brain but is also detectable at lower ...
C, von Poser, T C, Südhof
openaire   +2 more sources