Results 21 to 30 of about 4,005 (212)
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. [PDF]
PLoS ONE, 2010 Synaptotagmins are known to mediate diverse forms of Ca2+-triggered exocytosis through their C2 domains, but the principles underlying functional differentiation among them are unclear.
Mingshan Xue +8 more
doaj +1 more source
The binding of botulinum neurotoxins to different peripheral neurons [PDF]
, 2017 Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
core +1 more source
iScience, 2021 Summary: Extended synaptotagmins (E-Syts) localize at membrane contact sites between the endoplasmic reticulum (ER) and the plasma membrane to mediate inter-membrane lipid transfer and control plasma membrane lipid homeostasis.
Emma Stepinac +9 more
doaj +1 more source
The Ever-Growing Puzzle of Asynchronous Release
Frontiers in Cellular Neuroscience, 2019 Invasion of an action potential (AP) to presynaptic terminals triggers calcium dependent vesicle fusion in a relatively short time window, about a millisecond, after the onset of the AP.
Andrei Rozov +4 more
doaj +1 more source
The role of extended synaptotagmin at membrane contact sites in cancer research
Frontiers in Cell and Developmental Biology, 2023 Membrane contact sites (MCSs) are adjacent locations between the membranes of two different organelles and play important roles in various physiological processes, including cellular calcium and lipid signaling.
Yuetian Pan +6 more
doaj +1 more source
Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]
, 1994 Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G. +28 more
core +1 more source
Coming together to define membrane contact sites. [PDF]
, 2019 Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell ...
De Matteis, Maria Antonietta +14 more
core +7 more sources
Synaptotagmin Function Illuminated [PDF]
The Journal of General Physiology, 2003 Neurotransmitter release occurs by exocytosis of synaptic vesicles triggered by Ca2+ influx through voltage-gated Ca2+ channels. It was found many years ago that release shows a steep dependence on extracellular [Ca2+] and increases approximately with the fourth power of [Ca2+] ([Dodge ...
openaire +3 more sources
Extended-Synaptotagmin-1 and -2 control T cell signaling and function
EMBO Reports, 2023 Upon T-cell activation, the levels of the secondary messenger diacylglycerol (DAG) at the plasma membrane need to be controlled to ensure appropriate T-cell receptor signaling and T-cell functions.
Nathalia Benavides, Claudio G Giraudo
doaj +1 more source
Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of <i>Mycobacterium tuberculosis</i> antigens. [PDF]
ElifeAbstract Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that can be sensed by T cells, which are essential for the control of infection. In comparison to viral infections, Mtb antigens are relatively rare and hence, challenging to sample.
Kim SJ +6 more
europepmc +2 more sources