Results 11 to 20 of about 4,005 (212)

Differences in human cortical gene expression match the temporal properties of large-scale functional networks. [PDF]

PLoS ONE, 2014
We explore the relationships between the cortex functional organization and genetic expression (as provided by the Allen Human Brain Atlas). Previous work suggests that functional cortical networks (resting state and task based) are organized as two ...
Claudia Cioli, Hervé Abdi, Derek Beaton, Yves Burnod, Salma Mesmoudi   +4 more
doaj   +6 more sources

Distribution of mRNA for the exocytotic calcium sensor, synaptotagmin 9, in mouse brain [PDF]

IBRO Neuroscience Reports
The principal Ca2 + sensors that control fusion of synaptic vesicles are synaptotagmins 1, 2 and 9. Synaptotagmin 9 (Syt9) has received the least attention. We applied RNAscope techniques to coronal sections of adult mouse brain to study the distribution
Kwadwo O. Boateng, Lucian D. Hadford, Kelly L. Stauch, Anthony E. Kincaid, Wallace B. Thoreson   +4 more
doaj   +2 more sources

Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming

eLife, 2021
Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca2 ...
Bassam Tawfik, Joana S Martins, Sébastien Houy, Cordelia Imig, Paulo S Pinheiro, Sonja M Wojcik, Nils Brose, Benjamin H Cooper, Jakob Balslev Sørensen   +8 more
doaj   +1 more source

Unbiased proteomic and forward genetic screens reveal that mechanosensitive ion channel MSL10 functions at ER–plasma membrane contact sites in Arabidopsis thaliana

eLife, 2022
Mechanosensitive (MS) ion channels are an evolutionarily conserved way for cells to sense mechanical forces and transduce them into ionic signals. The channel properties of Arabidopsis thaliana MscS-Like (MSL)10 have been well studied, but how MSL10 ...
Jennette M Codjoe, Ryan A Richardson, Fionn McLoughlin, Richard David Vierstra, Elizabeth S Haswell   +4 more
doaj   +1 more source

Functional and Structural Analysis Reveals Distinct Biological Roles of Plant Synaptotagmins in Response to Environmental Stress [PDF]

Plant, Cell and Environment
Lourdes Rubio, Jorge Morello-Lopez, Carmen R. Beuzón   +2 more
exaly   +2 more sources

Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis

eLife, 2022
Synaptic communication relies on the fusion of synaptic vesicles with the plasma membrane, which leads to neurotransmitter release. This exocytosis is triggered by brief and local elevations of intracellular Ca2+ with remarkably high sensitivity.
Janus RL Kobbersmed, Manon MM Berns, Susanne Ditlevsen, Jakob B Sørensen, Alexander M Walter   +4 more
doaj   +1 more source

Dual-Function Exocytosis Regulator Has Yet Another Job. [PDF]

PLoS Biology, 2015
A new study shows that synaptotagmins, known to regulate the fusion of neurotransmitter vesicles with synaptic membranes, are also needed for the prior tethering and priming of vesicles. Read the Research Article.
Richard Robinson
doaj   +1 more source

The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites

Life Science Alliance, 2021
Plant SYT1 transports lipids between endoplasmic reticulum and plasma membrane in response to stress. The protein flexibility and lipid-binding specificity determine SYT1 function at molecular level. Non-vesicular lipid transfer at ER and plasma membrane
Juan L Benavente, Dritan Siliqi, Lourdes Infantes, Laura Lagartera, Alberto Mills, Federico Gago, Noemí Ruiz-López, Miguel A Botella, María J Sánchez-Barrena, Armando Albert   +9 more
doaj   +1 more source

Synaptotagmin-9 in mouse retina. [PDF]

Vis Neurosci, 2023
Abstract Synaptotagmin-9 (Syt9) is a Ca 2+ sensor mediating fast synaptic release expressed in various parts of the brain. The presence and role of Syt9 in retina is unknown.
Mesnard CS, Hays CL, Townsend LE, Barta CL, Gurumurthy CB, Thoreson WB.   +5 more
europepmc   +4 more sources

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. [PDF]

PLoS Biology, 2015
In forebrain neurons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively.
Taulant Bacaj, Dick Wu, Jacqueline Burré, Robert C Malenka, Xinran Liu, Thomas C Südhof   +5 more
doaj   +1 more source