Results 41 to 50 of about 4,005 (212)
Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals [PDF]
, 1994 The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the ...
Binz, T. +7 more
core +1 more source
Communications Biology, 2023 Calcium-evoked release of neurotransmitters from synaptic vesicles (SVs) is catalysed by SNARE proteins. The predominant view is that, at rest, complete assembly of SNARE complexes is inhibited (‘clamped’) by synaptotagmin and complexin molecules ...
Christopher A. Norman +3 more
doaj +1 more source
Open Biology, 2022 Dopamine (DA) neurons can release DA not just from axon terminals, but also from their somatodendritic (STD) compartment through a mechanism that is still incompletely understood. Using voltammetry in mouse mesencephalic brain slices, we find that STD DA
Benoît Delignat-Lavaud +4 more
doaj +1 more source
Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses. [PDF]
, 2013 Spontaneous electrical activity generated by developing sensory cells and neurons is crucial for the maturation of neural circuits. The full maturation of mammalian auditory inner hair cells (IHCs) depends on patterns of spontaneous action potentials ...
Adachi, R. +6 more
core +3 more sources
Autophagosomal membranes assemble at ER-plasma membrane contact sites
Molecular & Cellular Oncology, 2017 The biogenesis of autophagosome, the double membrane bound organelle related to macro-autophagy, is a complex event requiring numerous key-proteins and membrane remodeling events.
Anna Chiara Nascimbeni +2 more
doaj +1 more source
BMC Genomics, 2010 Background Synaptotagmin proteins were first identified in nervous tissue, residing in synaptic vesicles. Synaptotagmins were subsequently found to form a large family, some members of which play important roles in calcium triggered exocytic events ...
Craxton Molly
doaj +1 more source
Acta Physiologica, 2022 AbstractAimSYT11 and SYT13, two calcium‐insensitive synaptotagmins, are downregulated in islets from type 2 diabetic donors, but their function in insulin secretion is unknown. To address this, we investigated the physiological role of these two synaptotagmins in insulin‐secreting cells.MethodsCorrelations between gene expression levels were performed ...
Jones K. Ofori +8 more
openaire +2 more sources
The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses
Frontiers in Plant Science, 2014 Synaptotagmins are a large gene family in animals that have been extensively characterized due to their role as calcium sensors to regulate synaptic vesicle exocytosis and endocytosis in neurons, and dense core vesicle exocytosis for hormone secretion ...
Asako eUchiyama +5 more
doaj +1 more source
Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs
eLife, 2017 Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca2+ and SNAREs.
Sébastien Houy +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Membrane contact sites between the cortical endoplasmic reticulum (ER) and the plasma membrane (PM) provide a direct conduit for small molecule transfer and signaling between the two largest membranes of the cell.
Mohammad F. Zaman +6 more
doaj +1 more source