Results 51 to 60 of about 4,005 (212)
The Functional Significance of Synaptotagmin Diversity in Neuroendocrine Secretion
Frontiers in Endocrinology, 2013 Synaptotagmins (syts) are abundant, evolutionarily-conserved integral membrane proteins that play essential roles in regulated exocytosis in nervous and endocrine systems.
Paanteha K Moghadam, Meyer B Jackson
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Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain
FEBS Letters, 1995 Regulated Ca2+‐dependent release of transmitters from synaptic vesicles is an important characteristic of chemical neurotransmission. Synaptotagmins are abundant synaptic vesicle transmembrane proteins that probably function as Ca2+ sensors. Molecular cloning has identified four different synaptotagmin isoforms in mammals.
Craxton, Molly, Goedert, Michel
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The SNARE machinery in mast cell secretion
Frontiers in Immunology, 2012 Mast cells are known as inflammatory cells which exert their functions in allergic and anaphylactic reactions by secretion of numerous inflammatory mediators.
Axel eLorentz +3 more
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Potential roles of synaptotagmin family members in cancers: Recent advances and prospects
Frontiers in Medicine, 2022 With the continuous development of bioinformatics and public database, more and more genes that play a role in cancers have been discovered. Synaptotagmins (SYTs) are abundant, evolutionarily conserved integral membrane proteins composed of a short N ...
Huandan Suo, Nan Xiao, Kewei Wang
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Structure of dual receptor binding to botulinum neurotoxin B [PDF]
, 2014 Botulinum neurotoxins are highly toxic, and bind two receptors to achieve their high affinity and specificity for neurons. Here we present the first structure of a botulinum neurotoxin bound to both its receptors.
Berntsson, Ronnie P-A +3 more
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Synaptotagmins: That’s Why So Many [PDF]
Neuron, 2017 Synaptotagmin 7 (Syt7) was originally identified as a slow Ca2+ sensor for lysosome fusion, but its function at fast synapses is controversial. The paper by Luo and Südhof (2017) in this issue of Neuron shows that at the calyx of Held in the auditory brainstem Syt7 triggers asynchronous release during stimulus trains, resulting in reliable and ...
Chong, Chen, Peter, Jonas
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Frontiers in Cell and Developmental Biology, 2020 Glucose metabolism derangement is critically involved in the age-related memory loss but the underlying molecular mechanisms are still poorly understood.
Cristian Ripoli +7 more
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Membranes, 2022 Membrane proteins are broadly classified as transmembrane (TM) or peripheral, with functions that pertain to only a single bilayer at a given time. Here, we explicate a class of proteins that contain both transmembrane and peripheral domains, which we ...
Michael Overduin +4 more
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Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. [PDF]
PLoS ONE, 2016 Extended synaptotagmins (ESyts) are endoplasmic reticulum (ER) proteins composed of an N-terminal transmembrane region, a central SMP-domain, and five (ESyt1) or three C-terminal cytoplasmic C2-domains (ESyt2 and ESyt3). ESyts bind phospholipids in a Ca2+
Alessandra Sclip +3 more
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Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis
Frontiers in Pharmacology, 2022 The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca2+-triggered neurotransmitter release in neuronal synapses.
Ying Lai +14 more
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