The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release rely on the integrity of the C-terminal half of the SNARE domain of syntaxin-1A [PDF]
eLifeThe SNARE proteins are central in membrane fusion and, at the synapse, neurotransmitter release. However, their involvement in the dual regulation of the synchronous release while maintaining a pool of readily releasable vesicles remains unclear. Using a
Andrea Salazar Lázaro +3 more
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Molecular Mechanisms Underlying Neurotransmitter Release [PDF]
Annual Review of Biophysics, 2022 JOSÉ Rizo-Rey
exaly +2 more sources
LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons. [PDF]
PLoS Biology, 2016 Individual synapses vary significantly in their neurotransmitter release properties, which underlie complex information processing in neural circuits. Presynaptic Ca2+ homeostasis plays a critical role in specifying neurotransmitter release properties ...
Seok-Kyu Kwon +5 more
doaj +1 more source
Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release. [PDF]
PLoS ONE, 2014 Protein tyrosine kinases, which are highly expressed in the central nervous system, are implicated in many neural processes. However, the relationship between protein tyrosine kinases and neurotransmitter release remains unknown.
Zhao Zhang +9 more
doaj +1 more source
Mechanisms involved in nicotinic acetylcholine receptor-induced neurotransmitter release from sympathetic nerve terminals in the mouse vas deferens. [PDF]
PLoS ONE, 2011 Prejunctional nicotinic acetylcholine receptors (nAChRs) amplify postganglionic sympathetic neurotransmission, and there are indications that intraterminal Ca(2+) stores might be involved.
Damian J Williams +3 more
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Neurotransmitter release [PDF]
FEBS Letters, 1990 Axon terminals release more than one physiologically active substance. Synaptic messengers may be stored in two different types of vesicles. Small electron‐lucent vesicles mainly store classical low molecular weight transmitter substances and the larger electron‐dense granules store and release proteins and peptides.
openaire +2 more sources
Re-examining how complexin inhibits neurotransmitter release
eLife, 2014 Complexins play activating and inhibitory functions in neurotransmitter release. The complexin accessory helix inhibits release and was proposed to insert into SNARE complexes to prevent their full assembly.
Thorsten Trimbuch +5 more
doaj +1 more source
Neurotransmitter release is triggered by a calcium-induced rearrangement in the Synaptotagmin-1/SNARE complex primary interface [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaThorsten Trimbuch +2 more
exaly +2 more sources
The role of the C2A domain of synaptotagmin 1 in asynchronous neurotransmitter release.
PLoS ONE, 2020 Following nerve stimulation, there are two distinct phases of Ca2+-dependent neurotransmitter release: a fast, synchronous release phase, and a prolonged, asynchronous release phase.
Mallory C Shields +6 more
doaj +1 more source
The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression
eLife, 2022 Synaptic proteins and synaptic transmission are under homeostatic control, but the relationship between these two processes remains enigmatic. Here, we systematically investigated the role of E3 ubiquitin ligases, key regulators of protein degradation ...
Martin Baccino-Calace +2 more
doaj +1 more source