A Phenomenological Synapse Model for Asynchronous Neurotransmitter Release
Frontiers in Computational Neuroscience, 2016 Neurons communicate with each other via synapses. Action potentials cause release ofneurotransmitters at the axon terminal. Typically, this neurotransmitter release is tightly time-locked to the arrival of an action potential and is thus called ...
Tao eWang +8 more
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The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release rely on the integrity of the C-terminal half of the SNARE domain of syntaxin-1A [PDF]
eLifeThe SNARE proteins are central in membrane fusion and, at the synapse, neurotransmitter release. However, their involvement in the dual regulation of the synchronous release while maintaining a pool of readily releasable vesicles remains unclear. Using a
Andrea Salazar Lázaro +3 more
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Molecular Mechanisms Underlying Neurotransmitter Release [PDF]
Annual Review of Biophysics, 2022 José Rizo-Rey
exaly +2 more sources
LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons. [PDF]
PLoS Biology, 2016 Individual synapses vary significantly in their neurotransmitter release properties, which underlie complex information processing in neural circuits. Presynaptic Ca2+ homeostasis plays a critical role in specifying neurotransmitter release properties ...
Seok-Kyu Kwon +5 more
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Total ganglioside ablation at mouse motor nerve terminals alters neurotransmitter release level [PDF]
, 2010 Neuronal membrane gangliosides, forming a large family of sialylated glycosphingolipids, have been hypothesized to play important roles in synaptic transmission.
Furukawa, K. +4 more
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Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release. [PDF]
PLoS ONE, 2014 Protein tyrosine kinases, which are highly expressed in the central nervous system, are implicated in many neural processes. However, the relationship between protein tyrosine kinases and neurotransmitter release remains unknown.
Zhao Zhang +9 more
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Mechanisms involved in nicotinic acetylcholine receptor-induced neurotransmitter release from sympathetic nerve terminals in the mouse vas deferens. [PDF]
PLoS ONE, 2011 Prejunctional nicotinic acetylcholine receptors (nAChRs) amplify postganglionic sympathetic neurotransmission, and there are indications that intraterminal Ca(2+) stores might be involved.
Damian J Williams +3 more
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Neurotransmitter release [PDF]
FEBS Letters, 1990 Axon terminals release more than one physiologically active substance. Synaptic messengers may be stored in two different types of vesicles. Small electron‐lucent vesicles mainly store classical low molecular weight transmitter substances and the larger electron‐dense granules store and release proteins and peptides.
openaire +2 more sources
Determining the neurotransmitter concentration profile at active synapses [PDF]
, 2009 Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
Beato, M. +3 more
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Re-examining how complexin inhibits neurotransmitter release
eLife, 2014 Complexins play activating and inhibitory functions in neurotransmitter release. The complexin accessory helix inhibits release and was proposed to insert into SNARE complexes to prevent their full assembly.
Thorsten Trimbuch +5 more
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