Results 31 to 40 of about 35,245 (228)
Synaptotagmin II. A novel differentially distributed form of synaptotagmin
Journal of Biological Chemistry, 1991 Synaptotagmin is a synaptic vesicle membrane protein with properties suggestive of a role in synaptic vesicle exocytosis (Perin, M. S., Fried, V. A., Mignery, G. A., Jahn, R., and Südhof, T. C. (1990) Nature 345, 260-263). Here, we report the structure of a novel form of synaptotagmin named synaptotagmin II that is highly homologous to the originally ...
M, Geppert, B T, Archer, T C, Südhof
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Biological roles of plant synaptotagmins
European Journal of Cell Biology, 2023 Plant synaptotagmins (SYTs) are resident proteins of the endoplasmic reticulum (ER). They are characterized by an N-terminal transmembrane region and C2 domains at the C-terminus, which tether the ER to the plasma membrane (PM). In addition to their tethering role, SYTs contain a lipid-harboring SMP domain, essential for shuttling lipids between the ER
Francisco Benitez-Fuente +1 more
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eLife, 2016 The Ca2+-sensor synaptotagmin-1 that triggers neuronal exocytosis binds to negatively charged membrane lipids (mainly phosphatidylserine (PtdSer) and phosphoinositides (PtdIns)) but the molecular details of this process are not fully understood.
Ángel Pérez-Lara +8 more
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Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina
Frontiers in Ophthalmology, 2023 IntroductionLight responses of rod photoreceptor cells traverse the retina through three pathways. The primary pathway involves synapses from rods to ON-type rod bipolar cells with OFF signals reaching retinal ganglion cells (RGCs) via sign-inverting ...
Asia L. Sladek +2 more
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NEURONIC SYSTEM INSIDE NEURONS: MOLECULAR BIOLOGY AND BIOPHYSICS OF NEURONAL MICROTUBULES [PDF]
, 2004 Neurons are highly specialized cells that input, process, store and output information. Interneuronal communication is achieved in four basic ways: (i) Ca2+ evoked exocytosis with chemical neurotransmission, (ii) gap junction electrotonic coupling, (iii)
Georgiev, Danko +2 more
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Synaptotagmin 13: Structure and expression of a novel synaptotagmin
European Journal of Cell Biology, 2001 Synaptotagmins represent a family of putative vesicular trafficking proteins. With synaptotagmin 13, we have now identified a novel synaptotagmin, making this one of the largest families of trafficking proteins. Similar to synaptotagmins 3, 4, 6, 7, 9, and 11, synaptotagmin 13 is expressed at highest levels in brain but is also detectable at lower ...
C, von Poser, T C, Südhof
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SYT1-Associated Neurodevelopmental Disorder: A Narrative Review
Children, 2022 Synaptic dysregulations often result in damaging effects on the central nervous system, resulting in a wide range of brain and neurodevelopment disorders that are caused by mutations disrupting synaptic proteins. SYT1, an identified synaptotagmin protein,
Edith Riggs +3 more
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CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis [PDF]
, 2009 The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules.
Ackermann, Frauke +5 more
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Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle
eLife, 2015 In response to Ca2+ influx, a synapse needs to release neurotransmitters quickly while immediately preparing for repeat firing. How this harmonization is achieved is not known. In this study, we found that the Ca2+ sensor synaptotagmin 1 orchestrates the
Yunsheng Cheng +3 more
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eLife, 2017 The synaptic vesicle Ca2+ sensor Synaptotagmin binds Ca2+ through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated.
Zhuo Guan +5 more
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