Results 31 to 40 of about 32,650 (238)

Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion. [PDF]

PLoS ONE, 2010
BACKGROUND:Insulin secretion is a complex and highly regulated process. It is well established that cytoplasmic calcium is a key regulator of insulin secretion, but how elevated intracellular calcium triggers insulin granule exocytosis remains unclear ...
Natalia Gustavsson, Xiaorui Wang, Yue Wang, Tingting Seah, Jun Xu, George K Radda, Thomas C Südhof, Weiping Han   +7 more
doaj   +1 more source

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. [PDF]

PLoS Biology, 2015
In forebrain neurons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively.
Taulant Bacaj, Dick Wu, Jacqueline Burré, Robert C Malenka, Xinran Liu, Thomas C Südhof   +5 more
doaj   +1 more source

The highly expressed calcium‐insensitive synaptotagmin‐11 and synaptotagmin‐13 modulate insulin secretion

Acta Physiologica, 2022
SYT11 and SYT13, two calcium‐insensitive synaptotagmins, are downregulated in islets from type 2 diabetic donors, but their function in insulin secretion is unknown.
J. K. Ofori, A. Karagiannopoulos, Mohammad Barghouth, Mototsugu Nagao, Markus E. Andersson, V. Salunkhe, E. Zhang, A. Wendt, L. Eliasson   +8 more
semanticscholar   +1 more source

Increased miR‐34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS‐JNK‐p53 pathway in Alzheimer’s Disease

Aging Cell, 2020
Alzheimer's disease (AD) and cancer have inverse relationship in many aspects. Some tumor suppressors, including miR‐34c, are decreased in cancer but increased in AD.
Zhong-Li Shi, Kaixia Zhang, Hui-Min Zhou, Lei Jiang, B. Xie, Ruiyuan Wang, Wenzheng Xia, Ya-Juan Yin, Zhao-Yu Gao, Dong-Sheng Cui, Rui Zhang, Shun-Jiang Xu   +11 more
semanticscholar   +1 more source

Synaptotagmin-1–, Munc18-1–, and Munc13-1–dependent liposome fusion with a few neuronal SNAREs

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Neurotransmitter release is crucial for neuronal communication. Reproducing the steps that lead to neuronal exocytosis with lipid vesicles and purified proteins provides a powerful strategy to elucidate the molecular mechanisms underlying ...
Karolina P. Stepien, J. Rizo
semanticscholar   +1 more source

Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons

eLife, 2023
Neurotransmitter-filled synaptic vesicles (SVs) mediate synaptic transmission and are a hallmark specialization in neuronal axons. Yet, how SV proteins are sorted to presynaptic nerve terminals remains the subject of debate. The leading model posits that
Emma T Watson, Michaela M Pauers, Michael J Seibert, Jason D Vevea, Edwin R Chapman   +4 more
doaj   +1 more source

Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of <i>Mycobacterium tuberculosis</i> antigens. [PDF]

Elife
Kim SJ, Peterson JC, Olive AJ, Tafesse FG, Kulicke CA, Karamooz E, Lewinsohn D.   +6 more
europepmc   +2 more sources

Synaptotagmin-7 drives stress-induced cardiomyocyte necroptosis via the p53-Bak-mPTP axis. [PDF]

Theranostics
Li J, Wang S, Han Y, Liu J, Li Y, Zhang J, Guo L, Jin Y, Chang J, Liu T, Zhou L, Liu S, Yang G, Zhang S, Cao J, Na J, Sun T.   +16 more
europepmc   +2 more sources

Synaptotagmin-7 is required for synchronous but not asynchronous facilitation of glutamate release at cortical boutons [PDF]

Kotzadimitriou D, Langley H, McGowan E, Mendonca PRF, Tagliatti E, Timofeeva Y, Krishnakumar SS, Volynski KE.   +7 more
europepmc   +5 more sources

Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]

, 2012
Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
Cornelia A. Deeg, Amann, B., Naim, Hassan Y., Amann, Barbara, Hauck Stefanie M., Barbara Amann, Hassan Y. Naim, Swadzba Margarete E., Naim, H.Y., Naim Hassan Y., Hauck, S.M., Cornelia A Deeg, Swadzba, Margarete E., Margarete E. Swadzba, Deeg Cornelia A., Amann Barbara, Stefanie M Hauck, Stefanie M. Hauck, Hassan Y Naim, Deeg, Cornelia A., Hauck, Stefanie M., Margarete E Swadzba, Deeg, C.A., Swadzba, M.E.   +23 more
core   +2 more sources