Results 21 to 30 of about 32,650 (238)

A primordial synaptotagmin-independent function of complexin in regulated exocytosis. [PDF]

Nat Commun
Chen X, Wan C, Wu J, Ouyang Y, Puscher H, Yu H, Shen J.   +6 more
europepmc   +3 more sources

Domain structure of synaptotagmin (p65) [PDF]

, 1991
Synaptotagmin (p65) is an abundant and evolutionarily conserved protein of synaptic vesicles that contains two copies of an internal repeat homologous to the regulatory region of protein kinase C.
Perin, M. S., Jahn, R., Südhof, T. C., Brose, N.   +3 more
core   +4 more sources

Palmitoylation of the Parkinson’s disease-associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis

Science Signaling, 2023
Synaptotagmin-11 (Syt11) is a vesicle-trafficking protein that is linked genetically to Parkinson’s disease (PD). Likewise, the protein α-synuclein regulates vesicle trafficking, and its abnormal aggregation in neurons is the defining cytopathology of PD.
Gary P. H. Ho, Erin C. Wilkie, Andrew J. White, D. Selkoe   +3 more
semanticscholar   +1 more source

Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending

Advancement of science, 2023
Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the plasma membrane impairs synaptic transmission. However, the molecular mechanisms by which cholesterol deficiency leads to defects in vesicle fusion remain poorly ...
Houda Yasmine Ali Moussa, K. C. Shin, Janarthanan Ponraj, S. Kim, Je-Kyung Ryu, S. Mansour, Yongsoo Park   +6 more
semanticscholar   +1 more source

Fast resupply of synaptic vesicles requires synaptotagmin-3

Nature, 2022
Sustained neuronal activity demands a rapid resupply of synaptic vesicles to maintain reliable synaptic transmission. Such vesicle replenishment is accelerated by submicromolar presynaptic Ca2+ signals by an as-yet unidentified high-affinity Ca2+ sensor1,
Dennis J. Weingarten, Amita Shrestha, Kessa Juda-Nelson, Sarah A. Kissiwaa, Evan Spruston, Skyler L. Jackman   +5 more
semanticscholar   +1 more source

Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. [PDF]

PLoS ONE, 2010
Synaptotagmins are known to mediate diverse forms of Ca2+-triggered exocytosis through their C2 domains, but the principles underlying functional differentiation among them are unclear.
Mingshan Xue, Timothy K Craig, Ok-Ho Shin, Liyi Li, Chad A Brautigam, Diana R Tomchick, Thomas C Südhof, Christian Rosenmund, Josep Rizo   +8 more
doaj   +1 more source

Synaptotagmin-1 is a bidirectional Ca2+ sensor for neuronal endocytosis

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Precise and efficient coupling of endocytosis to exocytosis is critical for neurotransmission. The activity-dependent facilitation of endocytosis has been well established for efficient membrane retrieval; however, whether neural activity ...
Yang Chen, Shaoqin Hu, Xuanang Wu, Zhenli Xie, Yuan Wang, Bianbian Wang, Xiaopeng Li, Yingmei Pei, Yuhao Gu, Kai Huang, Jingxiao Huo, Anqi Wei, Cheng Bi, Zhen Lu, Q. Song, Huadong Xu, X. Kang, Shuli Shao, J. Long, Jian-Kang Liu, Zhuan Zhou, Rong Huang, Z. Chai, Changhe Wang   +23 more
semanticscholar   +1 more source

Arabidopsis synaptotagmin 1 mediates lipid transport in a lipid composition‐dependent manner

Traffic : the International Journal of Intracellular Transport, 2022
The endoplasmic reticulum (ER)‐plasma membrane (PM) contact sites (EPCSs) are structurally conserved in eukaryotes. The Arabidopsis ER‐anchored synaptotagmin 1 (SYT1), enriched in EPCSs, plays a critical role in plant abiotic stress tolerance.
Tiantian Qian, Chenlu Li, Furong Liu, K. Xu, Chun Wan, Yinghui Liu, Haijia Yu   +6 more
semanticscholar   +1 more source

Baker-Gordon Syndrome-Associated Synaptotagmin-1 Mutations Reduce Synaptic Strength in Mouse Primary and Human-Induced Neuronal Culture Models. [PDF]

J Neurosci
Fenske P, Hosseini H, Bouazza-Arostegui B, Trimbuch T, Herman MA, Rosenmund C.   +5 more
europepmc   +2 more sources

Increased lipolysis and energy expenditure in a mouse model with severely impaired glucagon secretion. [PDF]

PLoS ONE, 2011
BACKGROUND:Secretion of insulin and glucagon is triggered by elevated intracellular calcium levels. Although the precise mechanism by which the calcium signal is coupled to insulin and glucagon granule exocytosis is unclear, synaptotagmin-7 has been ...
Phing-How Lou, Natalia Gustavsson, Yue Wang, George K Radda, Weiping Han   +4 more
doaj   +1 more source