Results 11 to 20 of about 32,650 (238)

Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration

Nature Communications, 2023
Synaptotagmin-1 and synaptotagmin-7 are two prominent calcium sensors that regulate exocytosis in neuronal and neuroendocrine cells. Upon binding calcium, both proteins partially penetrate lipid bilayers that bear anionic phospholipids, but the specific ...
Kevin C. Courtney, Taraknath Mandal, Nikunj Mehta, Lanxi Wu, Yueqi Li, Debasis Das, Qiang Cui, Edwin R. Chapman   +7 more
doaj   +2 more sources

Ca2+ regulates the Drosophila Stoned-A and Stoned-B proteins interaction with the C2B domain of Synaptotagmin-1. [PDF]

PLoS ONE, 2012
The dicistronic Drosophila stoned gene is involved in exocytosis and/or endocytosis of synaptic vesicles. Mutations in either stonedA or stonedB cause a severe disruption of neurotransmission in fruit flies.
Carolina Soekmadji, Clement Angkawidjaja, Leonard E Kelly   +2 more
doaj   +4 more sources

Synaptotagmin-7 is an asynchronous calcium sensor for synaptic transmission in neurons expressing SNAP-23. [PDF]

PLoS ONE, 2014
Synchronization of neurotransmitter release with the presynaptic action potential is essential for maintaining fidelity of information transfer in the central nervous system.
Jens P Weber, Trine L Toft-Bertelsen, Ralf Mohrmann, Ignacio Delgado-Martinez, Jakob B Sørensen   +4 more
doaj   +3 more sources

Synaptotagmin gene content of the sequenced genomes [PDF]

BMC Genomics, 2004
Background Synaptotagmins exist as a large gene family in mammals. There is much interest in the function of certain family members which act crucially in the regulated synaptic vesicle exocytosis required for efficient neurotransmission.
Craxton Molly
doaj   +5 more sources

Alternative splicing of synaptotagmin 7 regulates oligomerization and short-term synaptic plasticity. [PDF]

Proc Natl Acad Sci U S A
Mehta N, Larson DT, Wozney M, Mishra S, Subramani S, Kaur S, Jain A, Chapman ER.   +7 more
europepmc   +4 more sources

Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse

Cell Reports, 2017
Summary GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear.
Peter Jonas, Rachel Satterfield, Samuel M Young   +2 more
exaly   +2 more sources

Triple Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission at Central GABAergic Synapses

Cell Reports, 2017
Synaptotagmin 7 (Syt7) is thought to be a Ca2+ sensor that mediates asynchronous transmitter release and facilitation at synapses. However, Syt7 is strongly expressed in fast-spiking, parvalbumin-expressing GABAergic interneurons, and the output synapses
Chong Chen, Rachel Satterfield, Samuel M. Young, Jr., Peter Jonas   +3 more
doaj   +2 more sources

Synaptotagmin 5, not synaptotagmin 1, is required for cortical granule exocytosis at fertilization of mouse eggs†. [PDF]

Biol Reprod
Mehlmann LM, Uliasz TF, Lowther KM.
europepmc   +3 more sources

Correction: Yamada et al. Extended-Synaptotagmin 1 Enhances Liver Cancer Progression Mediated by the Unconventional Secretion of Cytosolic Proteins. <i>Molecules</i> 2023, <i>28</i>, 4033. [PDF]

Molecules
Yamada K, Hannya Y, Oikawa T, Yoshida A, Katagiri K, Yoshida S, Koizumi R, Tago N, Shimoyama Y, Kawamura A, Mochimaru Y, Eto K, Yoshida K.   +12 more
europepmc   +3 more sources

Synaptotagmin gene content of the sequenced genomes [PDF]

, 2011
Background Synaptotagmins exist as a large gene family in mammals. There is much interest in the function of certain family members which act crucially in the regulated synaptic vesicle exocytosis required for efficient neurotransmission.

core   +10 more sources