Increased lipolysis and energy expenditure in a mouse model with severely impaired glucagon secretion. [PDF]
PLoS ONE, 2011 BACKGROUND:Secretion of insulin and glucagon is triggered by elevated intracellular calcium levels. Although the precise mechanism by which the calcium signal is coupled to insulin and glucagon granule exocytosis is unclear, synaptotagmin-7 has been ...
Phing-How Lou +4 more
doaj +1 more source
Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion. [PDF]
PLoS ONE, 2010 BACKGROUND:Insulin secretion is a complex and highly regulated process. It is well established that cytoplasmic calcium is a key regulator of insulin secretion, but how elevated intracellular calcium triggers insulin granule exocytosis remains unclear ...
Natalia Gustavsson +7 more
doaj +1 more source
Synaptotagmins in Neurodegeneration [PDF]
The Anatomical Record, 2009 AbstractSynaptotagmins (Syts) are transmembrane proteins involved in the regulation of membrane trafficking. Here, we summarize literature data that provide growing evidence that several Syts are involved in the pathophysiological mechanisms of temporal lobe epilepsy and Parkinson's disease, as well as few reports related to brain ischemia and ...
Gordana, Glavan +2 more
openaire +2 more sources
Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. [PDF]
PLoS Biology, 2015 In forebrain neurons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively.
Taulant Bacaj +5 more
doaj +1 more source
The Role of Calmodulin vs. Synaptotagmin in Exocytosis
Frontiers in Molecular Neuroscience, 2021 Exocytosis is a Ca2+-regulated process that requires the participation of Ca2+ sensors. In the 1980s, two classes of Ca2+-binding proteins were proposed as putative Ca2+ sensors: EF-hand protein calmodulin, and the C2 domain protein synaptotagmin. In the
Renhao Xue +8 more
doaj +1 more source
Synaptotagmin-9 in mouse retina
Visual Neuroscience, 2023 Abstract Synaptotagmin-9 (Syt9) is a Ca 2+ sensor mediating fast synaptic release expressed in various parts of the brain. The presence and role of Syt9 in retina is unknown.
Chris S. Mesnard +5 more
openaire +3 more sources
Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons
eLife, 2023 Neurotransmitter-filled synaptic vesicles (SVs) mediate synaptic transmission and are a hallmark specialization in neuronal axons. Yet, how SV proteins are sorted to presynaptic nerve terminals remains the subject of debate. The leading model posits that
Emma T Watson +4 more
doaj +1 more source
Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]
, 1994 Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G. +28 more
core +1 more source
O-GlcNAcase contributes to cognitive function in Drosophila [PDF]
, 2020 Contains fulltext : 219183.pdf (publisher's version ) (Open ...
Catinozzi, Marica +7 more
core +3 more sources
Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of <i>Mycobacterium tuberculosis</i> antigens. [PDF]
ElifeAbstract Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that can be sensed by T cells, which are essential for the control of infection. In comparison to viral infections, Mtb antigens are relatively rare and hence, challenging to sample.
Kim SJ +6 more
europepmc +2 more sources