Results 41 to 50 of about 32,650 (238)

Expression and distribution of synaptotagmin family members in the zebrafish retina

The Journal of comparative neurology, 2021
Synaptotagmins belong to a large family of proteins. Although various synaptotagmins have been implicated as Ca2+ sensors for vesicle replenishment and release at conventional synapses, their roles at retinal ribbon synapses remain incompletely ...
D. Henry, Christina Joselevitch, Gary G. Matthews, L. Wollmuth   +3 more
semanticscholar   +1 more source

Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. [PDF]

, 2011
Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait "anxiety".
Holsboer, Florian, Pütz Benno, Graf Cornelia, Peters, C., Bunck, Mirjam, Rieder, G., Steiner, Andrea, Baur Laura A., Mirjam Bunck, Markus Panhuysen, Rieder, Gabriele, Benno Pütz, Gabriele Rieder, Pütz, Benno, Claudia Kühne, Czibere Ludwig, Deussing, Jan, Laura A Baur, Weber Peter, Bunck, M., Peters, Christoph, Holsboer Florian, Graf, C., Czibere, L., Gemmeke, K., Cornelia Graf, Nafees Ahmad, Laura A. Baur, Widner, R., Graf, Cornelia, Hambsch Boris, Wittmann, A., Hambsch, B., Christoph Peters, Steiner Andrea, Peters Christoph, Weber, Peter, Ahmad, Nafees H.M., Wittmann, Anke, Kühne, C., Widner Regina, Panhuysen Markus, Landgraf Rainer, Reinheckel Thomas, Ahmad, N., Katja Gemmeke, Bunck Mirjam, Ludwig Czibere, Ahmad Nafees, Boris Hambsch, Wittmann Anke, Peter Weber, Deussing, Jan M., Rieder Gabriele, Holsboer, F., Panhuysen, Markus, Andrea Steiner, Reinheckel, Thomas, Kühne Claudia, Hambsch, Boris, Gemmeke Katja, Baur, L., Kühne, Claudia, Weber, P., Gemmeke, Katja, Thomas Reinheckel, Czibere, Ludwig, Jan M Deussing, Widner, Regina, Deussing, J., Ahmad, Nafees, Rainer Landgraf, Anke Wittmann, Pütz, B., Landgraf, R., Reinheckel, T., Florian Holsboer, Baur, Laura A., Landgraf, Rainer, Deussing Jan M., Panhuysen, M., Jan M. Deussing, Steiner, A., Regina Widner   +83 more
core   +1 more source

On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release

FEBS Open Bio, 2022
The mechanism of neurotransmitter release has been extensively characterized, showing that vesicle fusion is mediated by the SNARE complex formed by syntaxin‐1, SNAP‐25 and synaptobrevin. This complex is disassembled by N‐ethylmaleimide sensitive factor (
Josep Rizo, Guillaume David, Michael E. Fealey, Klaudia Jaczynska   +3 more
doaj   +1 more source

Molecular basis for synaptotagmin-1-associated neurodevelopmental disorder

Neuron, 2020
SUMMARY: At neuronal synapses, synaptotagmin-1 (syt1) acts as a Ca2+ sensor that synchronizes neurotransmitter release with Ca2+ influx during action potential firing.
M. Bradberry, Nicholas A. Courtney, M. J. Dominguez, Sydney M. Lofquist, Andrew T. Knox, R B Sutton, E. Chapman   +6 more
semanticscholar   +1 more source

Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release [PDF]

, 2013
SummaryIn forebrain neurons, knockout of synaptotagmin-1 blocks fast Ca2+-triggered synchronous neurotransmitter release but enables manifestation of slow Ca2+-triggered asynchronous release.
Südhof, Thomas C., Malenka, Robert C., Yang, Xiaofei, Bacaj, Taulant, Wu, Dick, Xu, Wei, Zhou, Peng, Morishita, Wade   +7 more
core   +1 more source

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
MANFRED GRATZL, Gratzl, Manfred
core   +1 more source

Differential roles for snapin and synaptotagmin in the synaptic vesicle cycle. [PDF]

PLoS ONE, 2013
Evoked synaptic transmission is dependent on interactions between the calcium sensor Synaptotagmin I and the SNARE complex, comprised of Syntaxin, SNAP-25, and Synaptobrevin.
Szi-Chieh Yu, Susan M Klosterman, Ashley A Martin, Elena O Gracheva, Janet E Richmond   +4 more
doaj   +1 more source

Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain [PDF]

, 1995
Regulated Ca2+-dependent release of transmitters from synaptic vesicles is an important characteristic of chemical neurotransmission. Synaptotagmins are abundant synaptic vesicle transmembrane proteins that probably function as Ca2+ sensors.
Michel Goedert, Molly Craxton, Craxton, Molly, Goedert, Michel   +3 more
core   +1 more source

Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina

Frontiers in Ophthalmology, 2023
IntroductionLight responses of rod photoreceptor cells traverse the retina through three pathways. The primary pathway involves synapses from rods to ON-type rod bipolar cells with OFF signals reaching retinal ganglion cells (RGCs) via sign-inverting ...
Asia L. Sladek, Wallace B. Thoreson, Wallace B. Thoreson   +2 more
doaj   +1 more source

The Primed SNARE-Complexin-Synaptotagmin Complex for Neuronal Exocytosis

Nature, 2017
Synaptotagmin, complexin, and neuronal SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) proteins mediate evoked synchronous neurotransmitter release, but the molecular mechanisms mediating the cooperation between these ...
Qiang-Jun Zhou, Peng Zhou, Austin L. Wang, Dick Wu, Ming-Lei Zhao, T. Südhof, A. Brunger   +6 more
semanticscholar   +1 more source