Results 61 to 70 of about 32,650 (238)
Cell Reports, 2017 Neurotransmission is a tightly regulated Ca2+-dependent process. Upon Ca2+ influx, Synaptotagmin1 (Syt1) promotes fusion of synaptic vesicles (SVs) with the plasma membrane.
Berrak Ugur +9 more
doaj +1 more source
, 2020 This dataset includes all raw data for experiments included in the manuscript. It also includes raw, unedited microscopy and blot images.Following nerve stimulation, there are two distinct phases of Ca2+-dependent neurotransmitter release: a fast ...
Bowers, Matthew +6 more
core +1 more source
eLife, 2020 Synchronous neurotransmitter release is triggered by Ca2+ binding to the synaptic vesicle protein Synaptotagmin 1, while asynchronous fusion and short-term facilitation is hypothesized to be mediated by plasma membrane-localized Synaptotagmin 7 (SYT7 ...
Zhuo Guan +3 more
semanticscholar +1 more source
Synaptotagmin I-ΔC2B. A novel synaptotagmin isoform with a single C2 domain in the bovine adrenal medulla [PDF]
, 2002 Synaptotagmin I is a 65 kDa type 1 membrane glycoprotein found in secretory organelles that plays a key role in regulated exocytosis. We have characterised two forms (long and short) of synaptotagmin I that are present in the bovine adrenal medulla.
Strasser, Jane E. +4 more
core +1 more source
Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution
FEBS Open Bio, 2023 Characterizing interactions of Synaptotagmin‐1 with the SNARE complex is crucial to understand the mechanism of neurotransmitter release. X‐ray crystallography revealed how the Synaptotagmin‐1 C2B domain binds to the SNARE complex through a so‐called ...
Klaudia Jaczynska +8 more
doaj +1 more source
PLoS ONE, 2017 During chemical transmission, the function of synaptic proteins must be coordinated to efficiently release neurotransmitter. Synaptotagmin 2, the Ca2+ sensor for fast, synchronized neurotransmitter release at the human neuromuscular junction, has ...
Mallory C Shields +10 more
doaj +1 more source
Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics
Toxins, 2018 Botulinum neurotoxins (BoNTs) are categorised into immunologically distinct serotypes BoNT/A to /G). Each serotype can also be further divided into subtypes based on differences in amino acid sequence. BoNTs are ~150 kDa proteins comprised of three major
Jonathan R. Davies +2 more
doaj +1 more source
Open Biology, 2022 Dopamine (DA) neurons can release DA not just from axon terminals, but also from their somatodendritic (STD) compartment through a mechanism that is still incompletely understood. Using voltammetry in mouse mesencephalic brain slices, we find that STD DA
Benoît Delignat-Lavaud +4 more
doaj +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Nature Communications, 2020 Synaptotagmin 1 is a vesicle-anchored membrane protein that functions as the Ca2+ sensor for synchronous neurotransmitter release. In this work, an arginine containing region in the second C2 domain of synaptotagmin 1 (C2B) is shown to control the ...
Sarah B. Nyenhuis +7 more
semanticscholar +1 more source