Results 71 to 80 of about 35,245 (228)
New insights into epileptic spasm generation and treatment from the TTX animal model
Epilepsia Open, EarlyView.Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann +2 more
wiley +1 more source
The Arabidopsis Synaptotagmin1 is enriched in endoplasmic reticulum-plasma membrane contact sites and confers cellular resistance to mechanical stresses [PDF]
, 2015 Eukaryotic endoplasmic reticulum (ER)-plasma membrane (PM) contact sites are evolutionarily conserved microdomains that have important roles in specialized metabolic functions such as ER-PM communication, lipid homeostasis, and Ca2+ influx.
Botella, Miguel A +8 more
core +2 more sources
Interdisciplinary Medicine, EarlyView.This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu +6 more
wiley +1 more source
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
eLife, 2017 Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites.
Alexander M Walter +15 more
doaj +1 more source
Epigallocatechin gallate inhibits SNARE‐dependent membrane fusion by blocking trans‐SNARE assembly
FEBS Open Bio, 2022 Insulin secretion is a signal‐triggered process that requires membrane fusion between the secretory granules and plasma membrane in pancreatic β cells. The exocytosis of insulin is mediated by target‐soluble N‐ethylmaleimide sensitive factor attachment ...
Min Zhu +4 more
doaj +1 more source
Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons [PDF]
, 2006 The mechanism by which synaptic vesicles (SVs) are recruited to the release site is poorly understood. One candidate mechanism for trafficking of SVs is the myosin-actin motor system.
Goda, Y, Tokuoka, H
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo +5 more
wiley +1 more source
UNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans. [PDF]
PLoS ONE, 2012 The recycling of synaptic vesicles requires the recovery of vesicle proteins and membrane. Members of the stonin protein family (Drosophila Stoned B, mammalian stonin 2) have been shown to link the synaptic vesicle protein synaptotagmin to the endocytic ...
Gregory P Mullen +9 more
doaj +1 more source
Postnatal developmental changes in the laryngeal chemosensory cell clusters of rats
Journal of Anatomy, EarlyView.Chemosensory cell clusters appeared in the rat larynx 2 days after birth and were already connected to afferent nerve fibers. Their number increased until 3 weeks of age, then stabilized while continuing to grow through the addition of new cells. Because their number reached a plateau around the time of weaning, their development may be linked to ...
Sayed Sharif Abdali +5 more
wiley +1 more source
Different strokes for different synaptotagmins [PDF]
Journal of General Physiology, 2017 JGP study shows how synaptotagmins 1 and 7 affect chromaffin cell granule fusion.
openaire +2 more sources