Results 91 to 100 of about 32,650 (238)
PLoS ONE, 2020 The synaptic vesicle protein, synaptotagmin, is the principle Ca2+ sensor for synaptic transmission. Ca2+ influx into active nerve terminals is translated into neurotransmitter release by Ca2+ binding to synaptotagmin’s tandem C2 domains, triggering the ...
M. R. Bowers, N. Reist
semanticscholar +1 more source
Synaptotagmin in Ca2+-Dependent Exocytosis Dynamic Action in a Flash [PDF]
, 2003 Synaptotagmins have been the popular candidates for the Ca2+ sensor that couples local rise in Ca2+ to neurotransmitter release. Studies in worm, fly, and mouse corroborate the likely role for synaptotagmin I, the best-studied synaptotagmin prototype, as
Yukiko Goda +3 more
core +1 more source
Mechanism of Synaptotagmin Action in Neurotransmitter Release [PDF]
, 2005 Neurotransmitter release occurs by fusion of the synaptic vesicle membrane with the plasma membrane. Formation of a highly stable complex, known as the SNARE (soluble NSF-attachment protein receptors) complex, brings the two membranes close in space ...
Arac-Ozkan, Demet
core +2 more sources
Impaired Motor Function in a Zebrafish Stathmin‐2 Knockout Model
Developmental Neurobiology, Volume 86, Issue 4, October 2026.ABSTRACT Stathmin‐2 (STMN2) is a microtubule‐associated protein that plays a role in the stability of microtubules in axons of the nervous system of animals. In this study, we generated a novel zebrafish STMN2 knockout (KO) model. STMN2 is represented by two genes in the zebrafish genome: stmn2a and stmn2b.
Tyler J. N. Gurberg +6 more
wiley +1 more source
Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Release of neurotransmitters relies on submillisecond coupling of synaptic vesicle fusion to the triggering signal: AP-evoked presynaptic Ca2+ influx.
E. Tagliatti +9 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2012 We investigated whether cortical glutamatergic and GABAergic release machineries can be differentiated on the basis of the nature and amount of proteins they express, by performing a quantitative analysis of the degree of co-localization of synaptotagmin
Luca eBragina +8 more
doaj +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Yves Henrotin +8 more
wiley +1 more source
Acta Crystallographica Section D, Volume 82, Issue 10, Page 1181-1194, October 2026.To facilitate structure‐based drug development, XFEL sources are of paramount interest. Here, we analyse the feasibility and data quality of serial femtosecond X‐ray crystallography compound screening at Linac Coherent Light Source and compare it with PETRA III synchrotron experiments.
Sven Falke +15 more
wiley +1 more source
Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations
FEBS Open BioNeurotransmitter release is triggered in microseconds by the two C2 domains of the Ca2+ sensor synaptotagmin‐1 and by SNARE complexes, which form four‐helix bundles that bridge the vesicle and plasma membranes. The synaptotagmin‐1 C2B domain binds to the
Josep Rizo +2 more
doaj +1 more source
eLifeDespite decades of intense study, the molecular basis of asynchronous neurotransmitter release remains enigmatic. Synaptotagmin (syt) 7 and Doc2 have both been proposed as Ca2+ sensors that trigger this mode of exocytosis, but conflicting findings have ...
Zhenyong Wu +7 more
doaj +1 more source