Results 101 to 110 of about 32,650 (238)

Postnatal developmental changes in the laryngeal chemosensory cell clusters of rats

Journal of Anatomy, Volume 249, Issue 4, Page 769-786, October 2026.
Chemosensory cell clusters appeared in the rat larynx 2 days after birth and were already connected to afferent nerve fibers. Their number increased until 3 weeks of age, then stabilized while continuing to grow through the addition of new cells. Because their number reached a plateau around the time of weaning, their development may be linked to ...
Sayed Sharif Abdali, Kanna Miyazaki, Takuya Yokoyama, Nobuaki Nakamuta, Tomoyuki Saino, Yoshio Yamamoto   +5 more
wiley   +1 more source

Synaptotagmin oligomers are necessary and can be sufficient to form a Ca2+-sensitive fusion clamp

FEBS Letters, 2019
The buttressed‐ring hypothesis, supported by recent cryo‐electron tomography analysis of docked synaptic‐like vesicles in neuroendocrine cells, postulates that prefusion SNAREpins are stabilized and organized by Synaptotagmin (Syt) ring‐like oligomers ...
Sathish Ramakrishnan, Manindranath Bera, Jeff Coleman, Shyam S. Krishnakumar, F. Pincet, J. Rothman   +5 more
semanticscholar   +1 more source

Turnip mosaic virus utilizes the lipid droplet biogenesis machinery to facilitate its propagation in plants

New Phytologist, Volume 252, Issue 2, Page 797-816, October 2026.
Potyvirus turnip mosaic virus induces neutral lipid accumulation and lipid droplet biogenesis in infected leaves for its own benefit. See also the Commentary on this article by May & Nagy, 252: 525–527. Summary Lipid droplets (LDs), which are dedicated to storing neutral lipids (NLs), are dynamic organelles involved in numerous other functions ...
Léna Jambou, Nathalie Arvy, Marguerite Batsale, Luc Sofer, Sara Shakir, Marielle Cochet, Vincent Simon, Charlotte Quinteau, Thomas Scotti, Nathan M. Doner, Satinder K. Gidda, Robert T. Mullen, Sabine D'Andréa, Jean‐Luc Gallois, Denis Coulon, Claire Bréhélin, Sylvie German‐Retana   +16 more
wiley   +1 more source

Neuronal regulation of fast synaptotagmin isoforms controls the relative contributions of synchronous and asynchronous release

Neuron, 2019
Summary Neurotransmitter release can be synchronous and occur within milliseconds of action potential invasion, or asynchronous and persist for tens of milliseconds. The molecular determinants of release kinetics remain poorly understood.
J. Turecek, W. Regehr
semanticscholar   +1 more source

PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis

Journal of Lipid Research, 2018
The transport of LDL-derived cholesterol from lysosomes to peroxisomes is facilitated by membrane contacts formed between the lysosomal protein synaptotagmin VII and the peroxisomal lipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2].
Ao Hu, Xue-Tong Zhao, Heng Tu, Ting Xiao, Ting Fu, Yan Wang, Yong Liu, Xiong-Jie Shi, Jie Luo, Bao-Liang Song   +9 more
doaj   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses

Journal of Neuroscience, 2018
When an action potential invades a presynaptic terminal it evokes large, brief Ca2+ signals that trigger vesicle fusion within milliseconds that is followed by a small residual Ca2+ (Cares) signal.
J. Turecek, W. Regehr
semanticscholar   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

Nature Communications, 2019
The synaptotagmin (syt) proteins have been widely studied for their role in regulating fusion of intracellular vesicles with the plasma membrane. Here we report that syt-17, an unusual isoform of unknown function, plays no role in exocytosis, and instead
David A Ruhl, Ewa K. Bomba-Warczak, Emma T. Watson, M. Bradberry, Tabitha A. Peterson, Trina Basu, A. Frelka, Chantell S. Evans, Joseph S. Briguglio, T. Basta, M. H. Stowell, Jeffrey N. Savas, A. Roopra, R. Pearce, R. Piper, E. Chapman   +15 more
semanticscholar   +1 more source

RETRACTED: Protein kinase C is a calcium sensor for presynaptic short-term plasticity

eLife, 2014
In presynaptic boutons, calcium (Ca2+) triggers both neurotransmitter release and short-term synaptic plasticity. Whereas synaptotagmins are known to mediate vesicle fusion through binding of high local Ca2+ to their C2 domains, the proteins that sense ...
Diasynou Fioravante, YunXiang Chu, Arthur PH de Jong, Michael Leitges, Pascal S Kaeser, Wade G Regehr   +5 more
doaj   +1 more source