Results 81 to 90 of about 32,650 (238)

Efficacy of fenfluramine in a pediatric epilepsy patient with a pathogenic SV2A variant: A case report

Epileptic Disorders, EarlyView.
Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori, Hiroshi Terashima, Yu kakimoto, Mitsuhiro Kato, Shumpei Uchino   +4 more
wiley   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

eLife, 2017
Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites.
Alexander M Walter, Rainer Müller, Bassam Tawfik, Keimpe DB Wierda, Paulo S Pinheiro, André Nadler, Anthony W McCarthy, Iwona Ziomkiewicz, Martin Kruse, Gregor Reither, Jens Rettig, Martin Lehmann, Volker Haucke, Bertil Hille, Carsten Schultz, Jakob Balslev Sørensen   +15 more
doaj   +1 more source

Epigallocatechin gallate inhibits SNARE‐dependent membrane fusion by blocking trans‐SNARE assembly

FEBS Open Bio, 2022
Insulin secretion is a signal‐triggered process that requires membrane fusion between the secretory granules and plasma membrane in pancreatic β cells. The exocytosis of insulin is mediated by target‐soluble N‐ethylmaleimide sensitive factor attachment ...
Min Zhu, Han Xu, Yuting Jiang, Haijia Yu, Yinghui Liu   +4 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Phylogenetic tree of synaptotagmin-7.

, 2012
Phylogenetic tree of synaptotagmin-7.
Xiang Zhang (19800), Jingni Hong (154171), Shaoxiong Ding (154166), Jun Chen (4238), Meng Qu (154161), Yong Mao (10385), Zixia Huang (154157), Tiantian Sun (154175)   +7 more
core   +1 more source

Minimal presynaptic protein machinery governing diverse kinetics of calcium-evoked neurotransmitter release

Nature Communications
Neurotransmitters are released from synaptic vesicles with remarkable precision in response to presynaptic calcium influx but exhibit significant heterogeneity in exocytosis timing and efficacy based on the recent history of activity.
Dipayan Bose, Manindra Bera, Christopher A. Norman, Yulia Timofeeva, Kirill E. Volynski, Shyam S. Krishnakumar   +5 more
doaj   +1 more source

UNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans. [PDF]

PLoS ONE, 2012
The recycling of synaptic vesicles requires the recovery of vesicle proteins and membrane. Members of the stonin protein family (Drosophila Stoned B, mammalian stonin 2) have been shown to link the synaptic vesicle protein synaptotagmin to the endocytic ...
Gregory P Mullen, Kiely M Grundahl, Mingyu Gu, Shigeki Watanabe, Robert J Hobson, John A Crowell, John R McManus, Eleanor A Mathews, Erik M Jorgensen, James B Rand   +9 more
doaj   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Botulism is induced by Clostridium botulinum neurotoxins (BoNTs). At neuromuscular junctions, BoNT/B binds to dual receptors: a plasma membrane resident polysialoganglioside and synaptotagmin, a synaptic vesicle protein transiently inserted ...
Alessandra Flores, J. Ramírez-Franco, Richard Desplantes, Kévin Debreux, G. Ferracci, Florian Wernert, Marie-Pierre Blanchard, Y. Maulet, F. Youssouf, Marion Sangiardi, C. Iborra, M. Popoff, M. Seagar, J. Fantini, C. Lévêque, O. El Far   +15 more
semanticscholar   +1 more source