Tyrosine kinase inhibition produces specific alterations in axon guidance in the grasshopper embryo [PDF]
, 1998 Tyrosine kinase signaling pathways are essential for process outgrowth and guidance during nervous system development. We have examined the roles of tyrosine kinase activity in programming growth cone guidance decisions in an intact nervous system in ...
Menon, Kaushiki P., Zinn, Kai
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The translational repressors Nanos and Pumilio have divergent effects on presynaptic terminal growth and postsynaptic glutamate receptor subunit composition [PDF]
, 2009 Pumilio (Pum) is a translational repressor that binds selectively to target mRNAs and recruits Nanos (Nos) as a corepressor. In the larval neuromuscular system, Pum represses expression of the translation factor eIF-4E and the glutamate receptor subunit ...
Andrews, Shane +4 more
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Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP
eLife, 2019 Neurotransmitter release requires formation of trans-SNARE complexes between the synaptic vesicle and plasma membranes, which likely underlies synaptic vesicle priming to a release-ready state.
Eric A Prinslow +4 more
doaj +1 more source
The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses
Frontiers in Plant Science, 2014 Synaptotagmins are a large gene family in animals that have been extensively characterized due to their role as calcium sensors to regulate synaptic vesicle exocytosis and endocytosis in neurons, and dense core vesicle exocytosis for hormone secretion ...
Asako eUchiyama +5 more
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Membrane contact sites - an interesting species, an interesting mix [PDF]
, 2013 In this issue of EMBO reports, Loewen and colleagues reveal a role for plasma membrane–endoplasmic reticulum contact sites in regulating phosphatidylcholine synthesis in budding ...
Miller, Vicky J, Stephens, David J
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Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment
eLife, 2014 Synaptotagmin (syt) 7 is one of three syt isoforms found in all metazoans; it is ubiquitously expressed, yet its function in neurons remains obscure. Here, we resolved Ca2+-dependent and Ca2+-independent synaptic vesicle (SV) replenishment pathways, and ...
Huisheng Liu +7 more
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eLifeSNAP25 is one of three neuronal SNAREs driving synaptic vesicle exocytosis. We studied three mutations in SNAP25 that cause epileptic encephalopathy: V48F, and D166Y in the synaptotagmin-1 (Syt1)-binding interface, and I67N, which destabilizes the SNARE ...
Anna Kádková +8 more
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Advantage of the Highly Restricted Odorant Receptor Expression Pattern in Chemosensory Neurons of Drosophila. [PDF]
, 2013 A fundamental molecular feature of olfactory systems is that individual neurons express only one receptor from a large odorant receptor gene family. While numerous theories have been proposed, the functional significance and evolutionary advantage of ...
Medina, Adriana +2 more
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Dissecting the functions of Synaptotagmin-1 and Synaptotagmin-7 in synaptic transmission
, 2023 Die zugrundeliegenden Mechanismen, die die neuronale Kommunikation durch synaptische Übertragung steuern, werden seit Jahrzehnten in zahlreichen Studien untersucht. Die Neurotransmission erfolgt im präsynaptischen Bouton, in dem sich spezialisierte sekretorische Organellen, die synaptischen Vesikel (SVs), befinden.
openaire +2 more sources
The Extended Synaptotagmins of Physcomitrium patens
PlantsMembrane contact sites (MCSs) between the endoplasmic reticulum and the plasma membrane enable the transport of lipids without membrane fusion. Extended Synaptotagmins (ESYTs) act at MCSs, functioning as tethers between two membrane compartments. In plants, ESYTs have been mainly investigated in A.
Alexander Kaier, Maria Ntefidou
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