PRRT2 Is a Key Component of the Ca2+-Dependent Neurotransmitter Release Machinery
Cell Reports, 2016 Heterozygous mutations in proline-rich transmembrane protein 2 (PRRT2) underlie a group of paroxysmal disorders, including epilepsy, kinesigenic dyskinesia, and migraine.
Pierluigi Valente +18 more
doaj +1 more source
Synaptotagmin 7 confers frequency invariance onto specialized depressing synapses
Nature, 2017 At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations.
J. Turecek, Skyler L. Jackman, W. Regehr
semanticscholar +1 more source
, 2020 The dataset includes all electrophysiological, western, and immunohistochemical data and its analysis. Also included are unedited representative blots and traces.
Bowers, Matthew, Reist, Noreen
core +1 more source
Kinetics of Synaptotagmin Responses to Ca2+ and Assembly with the Core SNARE Complex onto Membranes [PDF]
, 1999 The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2 ...
Lewis, Jessica L +5 more
core +1 more source
Electrostatics and Local Aromatic Residues Govern Lipid Binding and Membrane Penetration of Synaptotagmin C2 Domains [PDF]
Dong An, Manfred Lindau
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Phosphatidylinositol 4,5 bisphosphate controls the cis and trans interactions of synaptotagmin 1
bioRxiv, 2019 Synaptotagmin 1 acts as the Ca2+-sensor for synchronous neurotransmitter release; however, the mechanism by which it functions is not understood and is presently a topic of considerable interest.
Sarah B. Nyenhuis +2 more
semanticscholar +1 more source
Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP
eLife, 2019 Neurotransmitter release requires formation of trans-SNARE complexes between the synaptic vesicle and plasma membranes, which likely underlies synaptic vesicle priming to a release-ready state.
Eric A Prinslow +4 more
doaj +1 more source
Synaptic vesicle fusion and synaptotagmin: 2B or not 2B?
, 2002 Whether synaptotagmin is the calcium sensor in transmitter release has been controversial.
Connor, V., Lee, A.G.
core +1 more source
The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses
Frontiers in Plant Science, 2014 Synaptotagmins are a large gene family in animals that have been extensively characterized due to their role as calcium sensors to regulate synaptic vesicle exocytosis and endocytosis in neurons, and dense core vesicle exocytosis for hormone secretion ...
Asako eUchiyama +5 more
doaj +1 more source
Synaptotagmin: a calcium sensor on the synaptic vesicle surface
, 1992 Neurons release neurotransmitters by calcium-dependent exocytosis of synaptic vesicles. However, the molecular steps transducing the calcium signal into membrane fusion are still an enigma.
Jahn, R. +7 more
core +1 more source