Results 131 to 140 of about 32,650 (238)
Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment
eLife, 2014 Synaptotagmin (syt) 7 is one of three syt isoforms found in all metazoans; it is ubiquitously expressed, yet its function in neurons remains obscure. Here, we resolved Ca2+-dependent and Ca2+-independent synaptic vesicle (SV) replenishment pathways, and ...
Huisheng Liu +7 more
doaj +1 more source
Expression of synaptotagmin VIII in rat kidney
, 1998 The synaptotagmins are a family of integral membrane proteins proposed to function as regulators of both exocytosis and endocytosis. Here, we have used immunochemical techniques and RT-PCR to assess sites of renal expression of synaptotagmin VIII.
James B. Wade +5 more
core +1 more source
Models of synaptotagmin‐1 to trigger Ca2+‐dependent vesicle fusion
FEBS Letters, 2018 Vesicles in neurons and neuroendocrine cells store neurotransmitters and peptide hormones, which are released by vesicle fusion in response to Ca2+‐evoking stimuli.
Yongsoo Park, Je-Kyung Ryu
semanticscholar +1 more source
Synaptotagmin: fusogenic role for calcium sensor?
, 2006 Two recent studies focusing on synaptotagmin-1's role in synaptic vesicle fusion suggest that it may be key in bringing vesicle and target membranes together and in promoting SNARE assembly.
Sergey A Akimov +5 more
core +1 more source
Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis [PDF]
, 2001 Synaptotagmins I and II are Ca2+ binding proteins of synaptic vesicles essential for fast Ca2+-triggered neurotransmitter release. However, central synapses and neuroendocrine cells lacking these synaptotagmins still exhibit Ca2+-evoked exocytosis.
Fernández-Chacón, Rafael +13 more
core +1 more source
Concurrent Binding of Complexin and Synaptotagmin to Liposome-Embedded SNARE Complexes
, 2015 Synaptotagmin and complexin regulate SNARE-mediated synaptic vesicle exocytosis. It has been proposed that complexin clamps membrane fusion and that Ca2+-synaptotagmin displaces complexin from SNARE complexes to relieve this clamping activity.
Michael C. Chicka (1265919) +1 more
core +1 more source
Unraveling the Functions of Synaptotagmin and Munc13 in Neurotransmitter Release [PDF]
, 2017 Neurotransmitter release is a central event in interneuronal communication. The release machinery includes three SNAREs (soluble N-ethylmaleimide sensitive factor adaptor protein receptor) and Munc18-1 as core components.
Seven, Alpay Burak
core +1 more source
eLifeSNAP25 is one of three neuronal SNAREs driving synaptic vesicle exocytosis. We studied three mutations in SNAP25 that cause epileptic encephalopathy: V48F, and D166Y in the synaptotagmin-1 (Syt1)-binding interface, and I67N, which destabilizes the SNARE ...
Anna Kádková +8 more
doaj +1 more source
Isoquercitrin and localization of synaptotagmin-1.
, 2012 Left, The immuno-staining images show that synaptotagmin-1 localizes especially at spots along the neurites induced by isoquercitrin (Q) alone or combined with Rho inhibitors (Y-27632, C3 transferase). Green = synaptotagmin-1, blue = nuclei.
Marcy Zenobi-Wong (116962) +2 more
core +1 more source
Synaptotagmin isoforms differentially regulate glutamate and GABA release in the lateral habenula [PDF]
Dustin N. White +8 more
+5 more sources