Results 111 to 120 of about 32,650 (238)

Inositol pyrophosphate kinases in health and disease

FEBS Letters, Volume 600, Issue 17, Page 2379-2396, September 2026.
In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing, Chao Wang, Yuanyuan Chen, Weiwei Cheng, Zhaolei Jiang, Alex F. Chen, Chenglai Fu   +6 more
wiley   +1 more source

Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology

Nature Communications, 2018
Loss-of-function mutations in Parkin are the most common causes of autosomal recessive Parkinson’s disease (PD). Many putative substrates of parkin have been reported; their pathogenic roles, however, remain obscure due to poor characterization ...
Changhe Wang, X. Kang, Li Zhou, Z. Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Su-Hua Sun, Jie Li, Rui-Ying Jiao, Panli Zuo, Lianghong Zheng, Z. Yue, Zhuan Zhou   +15 more
semanticscholar   +1 more source

Membrane Association and Functional Mechanism of Synaptotagmin-1 in Triggering Vesicle Fusion

bioRxiv, 2020
Upon Ca2+ influx, synaptic vesicles fuse with the presynaptic plasma membrane (PM) to release neurotransmitters. Membrane fusion is triggered by synaptotagmin-1, a transmembrane protein in the vesicle membrane (VM), but the mechanism is under debate ...
R. Prasad, Huan-Xiang Zhou
semanticscholar   +1 more source

CSF synaptic protein concentrations are raised in those with atypical Alzheimer’s disease but not frontotemporal dementia

Alzheimer’s Research & Therapy, 2019
Background Increased CSF levels of a number of synaptic markers have been reported in Alzheimer’s disease (AD), but little is known about their concentrations in frontotemporal dementia (FTD). We investigated this in three synaptic proteins, neurogranin,
Mica T. M. Clarke, Ann Brinkmalm, Martha S. Foiani, Ione O. C. Woollacott, Carolin Heller, Amanda Heslegrave, Ashvini Keshavan, Nick C. Fox, Jonathan M. Schott, Jason D. Warren, Kaj Blennow, Henrik Zetterberg, Jonathan D. Rohrer   +12 more
doaj   +1 more source

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2

eLife, 2020
Insulin secretion from β-cells is reduced at the onset of type-1 and during type-2 diabetes. Although inflammation and metabolic dysfunction of β-cells elicit secretory defects associated with type-1 or type-2 diabetes, accompanying changes to insulin ...
Alex J B Kreutzberger, Volker Kiessling, Catherine A Doyle, Noah Schenk, Clint M Upchurch, Margaret Elmer-Dixon, Amanda E Ward, Julia Preobraschenski, Syed S Hussein, Weronika Tomaka, Patrick Seelheim, Iman Kattan, Megan Harris, Binyong Liang, Anne K Kenworthy, Bimal N Desai, Norbert Leitinger, Arun Anantharam, J David Castle, Lukas K Tamm   +19 more
doaj   +1 more source

Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Lysosomal dysfunction contributes to Alzheimer's disease (AD) by impairing protein clearance and promoting neuroinflammation. Cathepsin H (CTSH), a lysosomal protease, recently emerged as a protective AD locus. We investigated how CTSH is regulated and how it influences early AD pathophysiology.
Cynthia Picard, Gabriel Aumont‐Rodrigue, Isabel Sarty, Julia Loncke, Mélissa Savard, Laurence Maligne‐Bruneau, Judes Poirier, for the PREVENT‐AD research group   +7 more
wiley   +1 more source

Synaptotagmin 4 regulates pancreatic β-cell maturation by modulating the Ca2+ sensitivity of insulin secretion vesicles

Developmental Cell, 2018
Summary Islet β-cells from newborn mammals exhibit high basal insulin secretion and poor glucose-stimulated-insulin-secretion (GSIS). Here we show that β cells of newborns secrete more insulin than adults in response to similar intracellular Ca2 ...
Chen Huang, E. Walker, Prasanna K. Dadi, Ruiying Hu, Yanwen Xu, Wen-Jian Zhang, Tiziana Sanavia, Jisang Mun, Jennifer S. E. Liu, Gopika G. Nair, H. A. Tan, Sui Wang, M. Magnuson, C. Stoeckert, M. Hebrok, M. Gannon, W. Han, R. Stein, D. Jacobson, Guoqiang Gu   +19 more
semanticscholar   +1 more source

Expression and localization of synaptotagmin are unaffected by hydrophobic mutations.

, 2020
A, Representative western blots of transgenic synaptotagmin expression levels with actin as a loading control. B, Mean protein expression levels ± SEM, normalized to actin (One-way ANOVA, no significant differences).
Noreen E. Reist (7935767), Matthew R. Bowers (8423115)   +1 more
core   +1 more source

Structural and Biochemical Characterization of Botulinum Neurotoxin Subtype B2 Binding to Its Receptors

Toxins, 2020
Botulinum neurotoxins (BoNTs) can be used therapeutically to treat a wide range of neuromuscular and neurological conditions. A collection of natural BoNT variants exists which can be classified into serologically distinct serotypes (BoNT/B), and further
Jonathan R. Davies, Geoffrey Masuyer, Pål Stenmark   +2 more
doaj   +1 more source

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

eLife, 2012
The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Jiajie Diao, Patricia Grob, Daniel J Cipriano, Minjoung Kyoung, Yunxiang Zhang, Sachi Shah, Amie Nguyen, Mark Padolina, Ankita Srivastava, Marija Vrljic, Ankita Shah, Eva Nogales, Steven Chu, Axel T Brunger   +13 more
doaj   +1 more source