Results 51 to 60 of about 32,650 (238)

Synaptotagmin 13 is neuroprotective across motor neuron diseases

Acta Neuropathologica, 2020
In amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), spinal and lower brainstem motor neurons degenerate, but some motor neuron subtypes are spared, including oculomotor neurons (OMNs).
M. Nizzardo, M. Taiana, F. Rizzo, J. A. Benitez, J. Nijssen, I. Allodi, V. Melzi, N. Bresolin, G. Comi, E. Hedlund, S. Corti   +10 more
semanticscholar   +1 more source

PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium

eLife, 2016
The Ca2+-sensor synaptotagmin-1 that triggers neuronal exocytosis binds to negatively charged membrane lipids (mainly phosphatidylserine (PtdSer) and phosphoinositides (PtdIns)) but the molecular details of this process are not fully understood.
Ángel Pérez-Lara, Anusa Thapa, Sarah B Nyenhuis, David A Nyenhuis, Partho Halder, Michael Tietzel, Kai Tittmann, David S Cafiso, Reinhard Jahn   +8 more
doaj   +1 more source

SYT1-Associated Neurodevelopmental Disorder: A Narrative Review

Children, 2022
Synaptic dysregulations often result in damaging effects on the central nervous system, resulting in a wide range of brain and neurodevelopment disorders that are caused by mutations disrupting synaptic proteins. SYT1, an identified synaptotagmin protein,
Edith Riggs, Zaynab Shakkour, Christopher L. Anderson, Paul R. Carney   +3 more
doaj   +1 more source

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting

Science, 2019
Forgetting and receptor removal The trafficking of AMPA receptors to and from the surface of postsynaptic membranes regulates synaptic strength and underlies learning and memory. Awasthi et al.
Ankit Awasthi, B. Ramachandran, Saheeb Ahmed, E. Benito, Y. Shinoda, Noam Nitzan, A. Heukamp, Sabine Rannio, H. Martens, Jonas Barth, K. Burk, Yu-Tian Wang, A. Fischer, C. Dean   +13 more
semanticscholar   +1 more source

N-glycosylation is essential for vesicular targeting of synaptotagmin 1 [PDF]

, 2004
Synaptotagmins 1 and 7 are candidate Ca2+ sensors for exocytosis localized to synaptic vesicles and plasma membranes, respectively. We now show that the N-terminal intraluminal sequence of synaptotagmin 1, when transplanted onto synaptotagmin 7 ...
Maximov, A., Rhee, Jeong-Seop, Rosenmund, Christian, Suedhof, T., Mashimo, T., Mashimo, Tomoyuki, Han, W., Lao, Ye, Rhee, J., Suedhof, T. C., Han, Weiping, Rhee, J. S., Lao, Y., Südhof, Thomas C., Rosenmund, C., Han, W. P., Maximov, Anton   +16 more
core   +1 more source

Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle

eLife, 2015
In response to Ca2+ influx, a synapse needs to release neurotransmitters quickly while immediately preparing for repeat firing. How this harmonization is achieved is not known. In this study, we found that the Ca2+ sensor synaptotagmin 1 orchestrates the
Yunsheng Cheng, Jiaming Wang, Yu Wang, Mei Ding   +3 more
doaj   +1 more source

A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion

eLife, 2017
The synaptic vesicle Ca2+ sensor Synaptotagmin binds Ca2+ through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated.
Zhuo Guan, Maria Bykhovskaia, Ramon A Jorquera, Roger Bryan Sutton, Yulia Akbergenova, J Troy Littleton   +5 more
doaj   +1 more source

Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin

Nature Communications, 2019
Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs are constitutively active, so a major focus has been to identify fusion clamps that regulate their activity in synapses: the primary candidates are synaptotagmin (syt) 1
Nicholas A. Courtney, Huan Bao, Joseph S. Briguglio, E. Chapman   +3 more
semanticscholar   +1 more source

Creating Contacts Between Replication and Movement at Plasmodesmata – A Role for Membrane Contact Sites in Plant Virus Infections?

Frontiers in Plant Science, 2020
To infect their hosts and cause disease, plant viruses must replicate within cells and move throughout the plant both locally and systemically. RNA virus replication occurs on the surface of various cellular membranes, whose shape and composition become ...
Amit Levy, Amit Levy, Jens Tilsner, Jens Tilsner   +3 more
doaj   +1 more source

Diverse roles of Synaptotagmin-7 in regulating vesicle fusion

Current Opinion in Neurobiology, 2020
Synaptotagmin 7 (Syt7) is a multifunctional calcium sensor expressed throughout the body. Its high calcium affinity makes it well suited to act in processes triggered by modest calcium increases within cells. In synaptic transmission, Syt7 has been shown
Vincent Huson, W. Regehr
semanticscholar   +1 more source