Results 31 to 40 of about 707,375 (141)
Distinct functional properties of two electrogenic isoforms of the SLC34 Na‐Pi cotransporter
Physiological Reports, 2019 Inorganic phosphate (Pi) is crucial for proper cellular function in all organisms. In mammals, type II Na‐Pi cotransporters encoded by members of the Slc34 gene family play major roles in the maintenance of Pi homeostasis.
Natsuki Mizutani +2 more
doaj +1 more source
Local PI(4,5)P2 signaling inhibits fusion pore expansion during exocytosis
Cell Reports, 2023 Summary: Phosphatidylinositol(4,5)bisphosphate (PI(4,5)P2) is an important signaling phospholipid that is required for regulated exocytosis and some forms of endocytosis.
Muhmmad Omar-Hmeadi +2 more
doaj +1 more source
Structural organization and dynamics of FCHo2 docking on membranes
eLife, 2022 Clathrin-mediated endocytosis (CME) is a central trafficking pathway in eukaryotic cells regulated by phosphoinositides. The plasma membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) plays an instrumental role in driving CME initiation. The F-BAR
Fatima El Alaoui +11 more
doaj +1 more source
Frontiers in Pharmacology, 2015 Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4 ...
Masayuki X Mori +6 more
doaj +1 more source
RASSF4: Regulator of plasma membrane PI(4,5)P2 [PDF]
, 2017 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane–cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/
Dickson, Eamonn J, Eamonn J. Dickson
core +1 more source
Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms
Journal of Lipid Research, 2007 Previously, ceramide-1-phosphate (C1P) and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] were demonstrated to be potent and specific activators of group IVA cytosolic phospholipase A2 (cPLA2α). In this study, we hypothesized that these anionic lipids
Preeti Subramanian +4 more
doaj +1 more source
Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction
Advanced Science, EarlyView.Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen +5 more
wiley +1 more source
Biology, 2021 TREK-2-like channels in the pyramidal neurons of rat prefrontal cortex are characterized by a wide range of spontaneous activity—from very low to very high—independent of the membrane potential and the stimuli that are known to activate TREK-2 channels ...
Beata Dworakowska +2 more
doaj +1 more source
Advanced Science, EarlyView.A novel geometry‐resolved membrane platform provides a seamlessly integrated pipeline for studying curvature‐sensing proteins. By linking shotgun proteomics with quantitative imaging, this approach enables both the unbiased discovery and rigorous validation of novel sensors across the entire curvature range—positive, negative, and zero.
Takumi Komikawa +6 more
wiley +1 more source
Study of the cell biological role of Lowe Syndrome protein OCRL1 [PDF]
, 2009 Oculocerebrorenal syndrome of Lowe (OCRL) is caused by mutations in a phosphatidylinositol 5-phosphatase, OCRL1, and is believed to lead to an elevation of its preferred substrate, PI(4,5)P2.
Grieve, A.G.
core