Results 21 to 30 of about 62,994 (190)

PI(4,5)P2 binding sites in the Ebola virus matrix protein VP40 modulate assembly and budding [PDF]

Journal of Lipid Research
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and is lethal in a large percentage of those infected. The EBOV matrix protein viral protein 40 kDa (VP40) is a peripheral binding protein that forms a shell beneath the lipid bilayer in ...
Kristen A. Johnson, Melissa R. Budicini, Nisha Bhattarai, Tej Sharma, Sarah Urata, Bernard S. Gerstman, Prem P. Chapagain, Sheng Li, Robert V. Stahelin   +8 more
doaj   +2 more sources

The Dysferlin C2A Domain Binds PI(4,5)P2 and Penetrates Membranes. [PDF]

J Mol Biol, 2023
Dysferlin is a large membrane protein found most prominently in striated muscle. Loss of dysferlin activity is associated with reduced exocytosis, abnormal intracellular Ca2+ and the muscle diseases limb-girdle muscular dystrophy and Miyoshi myopathy. The cytosolic region of dysferlin consists of seven C2 domains with mutations in the C2A domain at the
Kwok E, Otto SC, Khuu P, Carpenter AP, Codding SJ, Reardon PN, Vanegas J, Kumar TM, Kuykendall CJ, Mehl RA, Baio J, Johnson CP.   +11 more
europepmc   +3 more sources

Lamin A/C and PI(4,5)P2-A Novel Complex in the Cell Nucleus. [PDF]

Cells, 2019
Lamins, the nuclear intermediate filaments, are important regulators of nuclear structural integrity as well as nuclear functional processes such as DNA transcription, replication and repair, and epigenetic regulations. A portion of phosphorylated lamin A/C localizes to the nuclear interior in interphase, forming a lamin A/C pool with specific ...
Escudeiro-Lopes S, Filimonenko VV, Jarolimová L, Hozák P.   +3 more
europepmc   +5 more sources

TXNIP interaction with GLUT1 depends on PI(4,5)P₂. [PDF]

Biochim Biophys Acta Biomembr, 2021
GLUT1 is a major glucose facilitator expressed ubiquitously among tissues. Upregulation of its expression plays an important role in the development of many types of cancer and metabolic diseases. Thioredoxin-interacting protein (TXNIP) is an α-arrestin that acts as an adaptor for GLUT1 in clathrin-mediated endocytosis.
Dykstra H, LaRose C, Fisk C, Waldhart A, Meng X, Zhao G, Wu N.   +6 more
europepmc   +3 more sources

PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes. [PDF]

Cell Mol Life Sci, 2022
Abstract Drosophila nephrocytes are an emerging model system for mammalian podocytes and proximal tubules as well as for the investigation of kidney diseases. Like podocytes, nephrocytes exhibit characteristics of epithelial cells, but the role of phospholipids in polarization of these cells is
Gass MM, Borkowsky S, Lotz ML, Siwek R, Schröter R, Nedvetsky P, Luschnig S, Rohlmann A, Missler M, Krahn MP.   +9 more
europepmc   +3 more sources

Physiological Calcium Concentrations Induce PI(4,5)P2 Clustering: PI(4,5)P2 as a Lipidic Calcium Sensor [PDF]

Biophysical Journal, 2013
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a minor component of the plasma membrane of eukaryotic cells that is essential for several cellular mechanisms, including organization and remodeling of the actin cytoskeleton, membrane trafficking, endocytosis and exocytosis.
João Sarmento, Maria, Coutinho, Ana, Fedorov, Aleksander, Prieto, Manuel, Fernandes, Fábio   +4 more
openaire   +1 more source

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Makhtar, Mokhairi, Neagu, Daniel, Ridley, Mick, Yang, Longzhi   +3 more
core   +2 more sources

Mechanisms of PI(4,5)P2 Enrichment in HIV-1 Viral Membranes. [PDF]

J Mol Biol, 2020
Phosphatidylinositol 4,5-bisphosphate (PIP2) is critical for HIV-1 virus assembly. The viral membrane is enriched in PIP2, suggesting that the virus assembles at PIP2-rich microdomains. We showed previously that in model membranes PIP2 can form nanoscopic clusters bridged by multivalent cations.
Wen Y, Feigenson GW, Vogt VM, Dick RA.
europepmc   +3 more sources

A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila

eLife, 2020
Synaptic vesicle (SV) endocytosis is coupled to exocytosis to maintain SV pool size and thus neurotransmitter release. Intense stimulation induces activity-dependent bulk endocytosis (ADBE) to recapture large quantities of SV constituents in large ...
Tsai-Ning Li, Yu-Jung Chen, Ting-Yi Lu, You-Tung Wang, Hsin-Chieh Lin, Chi-Kuang Yao   +5 more
doaj   +1 more source

Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate [PDF]

, 2015
During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55(Gag) is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly. We show that Rab27a controls the
Amigorena, S., Banchio, C., Benaroch, P., Cabrini, M., de Saint Basile, G., Duette, G., Freed, E. O., Geffner, J., Gerber, P. P., Jancic, C., Moita, C. F., Moita, L. F., Ostrowski, M., Paoletti, L., Pietrasanta, L. I., Sigaut, L., von Bilderling, C.   +16 more
core   +4 more sources