Ion channel regulation by phosphoinositides analyzed with VSPs – PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility [PDF]
Frontiers in Pharmacology, 2015 The activity of many proteins depends on the phosphoinositide (PI) content of the membrane. E.g., dynamic changes of the concentration of PI(4,5)P2 are cellular signals that regulate ion channels.
Alexandra eRjasanow +4 more
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RASSF4: Regulator of plasma membrane PI(4,5)P2. [PDF]
Journal of Cell Biology, 2017 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane-cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/
Balla +12 more
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TPTE, a testis-specific PTEN family member, drives spermatogenesis via PI(4,5)P2 synthesis [PDF]
Cell Death and DiseasePhosphatidylinositol(4,5) bisphosphate (PI(4,5)P2) is the most abundant phosphoinositides species and plays regulatory roles in spermatogenesis. However, the role of the phosphatases that regulate the production of PI(4,5)P2 during spermatogenesis has ...
Xu Chen +14 more
doaj +2 more sources
Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2 [PDF]
Nature CommunicationsUnconventional secretion of Fibroblast Growth Factor 2 (FGF2) is mediated by direct translocation across the plasma membrane. This process is initiated by PI(4,5)P2-dependent FGF2 oligomerization at the inner plasma membrane leaflet.
Manpreet Kaur +2 more
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A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8 [PDF]
Life Science Alliance, 2021 This study uncovers a critical role of DOCK8 in coupling PI(4,5)P2 signaling with Cdc42 activation through its DHR-1 domain during interstitial leukocyte migration.
Tetsuya Sakurai +10 more
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The plasma membrane inner leaflet PI(4,5)P2 is essential for the activation of proton-activated chloride channels [PDF]
Nature CommunicationsProton-activated chloride (PAC) channels, ubiquitously expressed in tissues, regulate intracellular Cl- levels and cell death following acidosis. However, molecular mechanisms and signaling pathways involved in PAC channel modulation are largely unknown.
Woori Ko +4 more
doaj +2 more sources
Interaction between the Lentil Lipid Transfer Protein Lc-LTP2 and Its Novel Signal Ligand PI(4,5)P2 [PDF]
Membranes, 2020 It is known that plant lipid transfer proteins (LTPs) bind a broad spectrum of ligands including fatty acids (FAs), phospho- and glycolipids, acyl-coenzyme A and secondary metabolites.
Daria Melnikova +3 more
doaj +2 more sources
PI(4,5)P2: signaling the plasma membrane. [PDF]
Biochem J, 2022 In the almost 70 years since the first hints of its existence, the phosphoinositide, phosphatidyl-D-myo-inositol 4,5-bisphosphate has been found to be central in the biological regulation of plasma membrane (PM) function. Here, we provide an overview of the signaling, transport and structural roles the lipid plays at the cell surface in animal cells ...
Wills RC, Hammond GRV.
europepmc +3 more sources
Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2 [PDF]
Nature Communications, 2019 Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs). Here authors unveil a mechanism by which PI(4,5)P2/PI(3,4)P2 allosterically enhances ORP1-mediated cholesterol exit from ...
Jiangqing Dong +11 more
doaj +3 more sources
PI(4,5)P2 regulates the gating of NaV1.4 channels. [PDF]
J Gen Physiol, 2023 Voltage-gated sodium (NaV) channels are densely expressed in most excitable cells and activate in response to depolarization, causing a rapid influx of Na+ ions that initiates the action potential. The voltage-dependent activation of NaV channels is followed almost instantaneously by fast inactivation, setting the refractory period of excitable tissues.
Gada KD +5 more
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