Results 81 to 90 of about 1,796,810 (372)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Digital handover of China-Russia Eastern Gas Pipeline and docking with integrity management system

You-qi chuyun, 2020
To achieve the construction goal of "full digital handover, full intelligent operation and full life cycle management" of the China-Russia Eastern Gas Pipeline Project, the basic process and working mechanism of digital handover were proposed, and the ...
Xinwei OU, Pengchao CHEN, Kai REN, Yibo LI, Panxi CHEN   +4 more
doaj   +1 more source

Alzheimer's disease drug development pipeline: 2024

Alzheimer's & Dementia
New therapies to prevent or delay the onset of symptoms, slow progression, or improve cognitive and behavioral symptoms of Alzheimer's disease (AD) are needed.
Jeffrey L Cummings, Yadi Zhou, Garam Lee, K. Zhong, Jorge Fonseca, Feixiong Cheng   +5 more
semanticscholar   +1 more source

The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin

Drugs, 2021
The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of resistance caused by the selective pressure from increased usage of antifungal agents in prophylaxis, empiric therapy, and agriculture.
M. Hoenigl, Rosanne Sprute, Matthias Egger, A. Arastehfar, O. Cornely, R. Krause, C. Lass‐Flörl, J. Prattes, A. Spec, G. Thompson, N. Wiederhold, J. Jenks   +11 more
semanticscholar   +1 more source

Low-latency analysis pipeline for compact binary coalescences in the advanced gravitational wave detector era

, 2016
The multi-band template analysis (MBTA) pipeline is a low-latency coincident analysis pipeline for the detection of gravitational waves (GWs) from compact binary coalescences.
Adams, T, Buskulic, D., Germain, V., Guidi, G. M., Marion, F., Montani, M., Mours, B., Piergiovanni, F., Wang, G.   +8 more
core   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Optimal pigging scheme and residual water distribution law in the initial pigging of undulate pipelines

You-qi chuyun, 2021
Water accumulation in the low-lying areas of undulate pipelines will seriously threaten the operation of pipelines. Herein, the optimal pigging scheme for the initial pigging stage of the large undulate pipelines in mountainous areas was studied by test,
Hua GE, Kaihong LI, Leichao WANG, Sha CHEN, Qiang XU, Bojun ZHANG, Zili LI   +6 more
doaj   +1 more source

What is the pipeline for future medications for obesity?

International Journal of Obesity
Obesity is a chronic disease associated with increased risk of obesity-related complications and mortality. Our better understanding of the weight regulation mechanisms and the role of gut-brain axis on appetite has led to the development of safe and ...
Eka Melson, Uzma Ashraf, D. Papamargaritis, M. Davies   +3 more
semanticscholar   +1 more source

KMOS Data Flow: Reconstructing Data Cubes in One Step

, 2010
KMOS is a multi-object near-infrared integral field spectrometer with 24 deployable pick-off arms. Data processing is inevitably complex. We discuss specific issues and requirements that must be addressed in the data reduction pipeline, the calibration ...
Berbel, Alex Agudo, Davies, Richard, Ott, Thomas, Schreiber, Natascha Foerster, Wiezorrek, Erich   +4 more
core   +1 more source

The COPD Pipeline

COPD: Journal of Chronic Obstructive Pulmonary Disease, 2009
Smoking Cessation. Nabi Biopharmaceuticals has received a NIDA grant of $4+ million in partial support of the next and, one hopes, final phases of a possible nicotine conjugate vaccine.
openaire   +3 more sources