Results 41 to 50 of about 347,254 (269)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Automated pipeline reconstruction using deep learning & instance segmentation
ISPRS Open Journal of Photogrammetry and Remote Sensing, 2023 BIM is a powerful tool for the construction industry as well as for various other industries, so that its use has increased massively in recent years. Laser scanners are usually used for the measurement, which, in addition to the high acquisition costs ...
Lukas Hart +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Литьë и металлургия, 2019 High pressure hose (HPH) is a flexible pipeline for the transportation of special hydraulic and motor fluids based on mineral oil, liquid fuel, grease or water emulsion under pressure, to transfer the working force.
I. V. Borisovets, T. P. Kurenkova
doaj +1 more source
Energy Reports, 2023 The application of core annular flow (CAF) has become an interesting solution in transporting heavy oil through pipeline because of its energy reduction and cost efficiency.
Cindy Dianita +2 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Shock and Vibration, 2020 Vibrations due to mechanical excitation and internal and external fluid flow can cause fatigue in pipelines and leaks in fittings. A beam-based dynamic vibration absorber (beam DVA) is a device comprising an L-shaped beam with a concentrated mass at its ...
Mehrdad Shemshadi +2 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source