Results 61 to 70 of about 14,875 (278)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Reliability and Quality of Complex Systems

Надежность и качество сложных систем
Background. Prolonged operation of gas pipeline shut-off valves leads to gradual wear of the sealing elements of ball valves and, as a result, to their leakiness.
D.S. Boyarkin, V.D. Yezhizhanskiy, D.A. Golushko, I.R. Abuzyarov, A.V. Lysenko   +4 more
doaj   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Very long baseline astrometry of PSR J1012+5307 and its implications on alternative theories of gravity

, 2020
PSR J1012+5307, a millisecond pulsar in orbit with a helium white dwarf (WD), has been timed with high precision for about 25 years. One of the main objectives of this long-term timing is to use the large asymmetry in gravitational binding energy between
Deller, Adam T., Ding, Hao, Freire, Paulo, Kaplan, David L., Lazio, T. Joseph W., Shannon, Ryan, Stappers, Benjamin   +6 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Development of the orifice plate with a cone swirler flow conditioner [PDF]

, 2005
Purpose - The sensitivity of orifice plate metering to poorly conditioned and swirling flows are subjects of concerns to flow meter users and manufacturers.
Ahmadi, A., Beck, S.B.M.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The Absolute Magnitudes of Red Horizontal Branch Stars in the ugriz System

, 2009
Based on photometric data of the central parts of eight globular clusters and one open cluster presented by An and his collaborators, we select red horizontal branch (RHB) stars in the (g-r)0-g0 diagram and make a statistical study of the distributions ...
An, An, Anthony-Twarog, Bedin, Carney, Carretta, Chonis, Feast, G. Zhao, J. K. Zhao, Sirko, Stanek, van den Bergh, Y. Q. Chen, Zhao   +14 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

First measurement of Mg isotope abundances at high redshifts and accurate estimate of Delta alpha/alpha

, 2011
(Abridged) We use a high-resolution spectrum of the quasar HE0001-2340 observed with the UVES/VLT to measure Mg isotope abundances in the intervening absorption-line systems at high redshifts.
Aldenius, Ashenfelter, Badenes, Batteiger, Berengut, Centurión, Chand, Dzuba, Dzuba, D’Odorico, Edlén, Griest, Gyngard, Hughes, I. I. Agafonova, J. L. Hou, Jones, José, José, Karakas, Karakas, Karakas, Levshakov, Levshakov, Levshakov, Levshakov, Levshakov, Mazzali, McWilliam, Molaro, Molaro, Morton, Murphy, Murphy, P. Molaro, Porsev, Quast, Reimers, Richter, S. A. Levshakov, Salumbides, Sarazin, Seitenzahl, Stehle, Tanaka, Whitmore, Wisotzki, Wisotzki, Yong, Zinner   +49 more
core   +1 more source