Results 51 to 60 of about 14,807 (258)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
The Absolute Magnitudes of Red Horizontal Branch Stars in the ugriz System
, 2009 Based on photometric data of the central parts of eight globular clusters and one open cluster presented by An and his collaborators, we select red horizontal branch (RHB) stars in the (g-r)0-g0 diagram and make a statistical study of the distributions ...
An +14 more
core +1 more source
Pressure Drop in Capsule Transporting Bends Carrying Spherical Capsules [PDF]
, 2012 One of the most important parameters in designing a capsule transporting pipeline is the pressure drop in the pipes carrying capsules and associated pipe fittings such as bends etc.
Itoro Ido +3 more
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Parametric modelling of control cable fittings geometric configuration with interpolation of FEA results [PDF]
MATEC Web of ConferencesStudying the behavior of control cable fittings (actually a pipe-type part) during radial crimping for fixation on the pipeline is a difficult task since it is necessary to control the presence of obvious plastic deformations: on the one hand ...
Matiukh Serhii +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Reliability and Quality of Complex Systems
Надежность и качество сложных системBackground. Prolonged operation of gas pipeline shut-off valves leads to gradual wear of the sealing elements of ball valves and, as a result, to their leakiness.
D.S. Boyarkin +4 more
doaj +2 more sources
, 2015 The unprecedentedly bright afterglow of Swift GRB 130606A at z = 5.91 gave us a unique opportunity to probe the reionization era by high precision analyses of the redward damping wing of Ly alpha absorption, but the reported constraints on the neutral ...
Aoki, Kentaro +3 more
core +1 more source