Results 51 to 60 of about 111,822 (311)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Corrosion behavior of X100 pipeline steel and its heat-affected zones in simulated Korla soil solution under alternating current interference

open access: yes工程科学学报, 2020
In recent years, many accidents caused by alternating current (AC) corrosion have been reported. AC corrosion has become a serious potential damage to buried steel pipelines.
Yong YANG   +3 more
doaj   +1 more source

Assessment of brittle fractures in CO2 transportation pipelines: A hybrid fluid-structure interaction model [PDF]

open access: yes, 2016
In order to transport dense-phase CO2 captured from power and industrial emission sources in the Carbon Capture and Storage (CCS) chain, pressurised steel pipelines are considered the most practical tool.
Brownb, S   +3 more
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Design of a four-point bend test for ultra-low cycle fatigue of pipelines under inelastic bending [PDF]

open access: yes, 2012
This master thesis is situated in the research domain dealing with the ductile failure of pipelines under extreme loading conditions. It is part of an umbrella research aiming to develop innovative experimental and computational methodologies to simulate
De Waele, Wim, Muylaert, Toon
core  

Team One Carbon Catcher Design Report [PDF]

open access: yes, 2020
Overview The burning of fossil fuels largely contributes to the increase of CO2 in the atmosphere. The US Department of Transportation alone contributed almost 6 million metric tons of carbon dioxide emissions in 2018 (EIA).
Brusa, Josh   +16 more
core  

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Method for detection of deformation stress of large-diameter and high-pressure pipeline under complex terrain

open access: yesYou-qi chuyun, 2020
China-Russia Eastern Gas Pipeline is characterized by ultra-large diameter, high grade steel (X80) and high pressure rating. It is located in the area with geologically active permafrost and semi-permafrost zones in the north, where is prone to ...
Yukun LI   +4 more
doaj   +1 more source

Temperature robust PCA based stress monitoring approach [PDF]

open access: yes, 2016
In this paper, a guided wave temperature robust PCA-based stress monitoring methodology is proposed. It is based on the analysis of the longitudinal guided wave propagating along the path under stress.
Mujica Delgado, Luis Eduardo   +4 more
core   +3 more sources

Numerical Investigation of Dynamic Pipe-Soil Interaction on Electrokinetic-Treated Soft Clay Soil [PDF]

open access: yes, 2020
© 2019 American Society of Civil Engineers. Researchers have underscored the importance for a pipeline to safeguard against adverse effects resulting from its displacement in the vertical, axial, and lateral directions because of the low shear strength ...
Joshua, H.N., Kara, Fuat
core   +1 more source

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