Results 21 to 30 of about 6,372 (199)

Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities

Journal of the Turkish Chemical Society, Section A: Chemistry, 2016
Synthesis of coordination compounds of Zinc(II), Copper(II), Nickel(II), Cobalt(II) and Iron(II) with mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid has been studied.
Yusuf Oloruntoyin Ayipo, Joshua Ayoola Obaleye, Umar Muhammad Badeggi   +2 more
doaj   +2 more sources

Piperaquine and Metabolites - Bioanalysis and Pharmacokinetics [PDF]

, 2017
Antimalarial piperaquine (PQ) is currently used as a partner drug with dihydroartemisinin (DHA), exhibiting high cure rates (>95%) for P. falciparum. Despite its raising usage worldwide with DHA, PQ is synthetically developed outside of big pharma pipelines.
Aziz, Mohd Yusmaidie
openaire   +3 more sources

Diversity in Translation: Equal Is Greater Than. [PDF]

Clin Transl Sci
Clinical and Translational Science, Volume 19, Issue 9, September 2026.
Price ET, Wagner JA.
europepmc   +2 more sources

Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Woime AW.
europepmc   +2 more sources

Molecular evidence of incipient speciation within Anopheles gambiae s.s. in West Africa [PDF]

, 2001
We karyotyped and identified by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis Anopheles gambiae s.s. samples collected in several African countries. The data show the existence of two non-panmictic molecular forms,
Akogbeto, M, della Torre, A, Dossou-Yovo, J, Coluzzi, M, Fanello, C, Favia, G, Petrarca, V   +6 more
core   +5 more sources

Impact of Dolutegravir-Based Antiretroviral Therapy on Piperaquine Exposure following Dihydroartemisinin-Piperaquine Intermittent Preventive Treatment of Malaria in Pregnant Women Living with HIV [PDF]

, 2022
Dihydroartemisinin-piperaquine, an artemisinin-based combination therapy, has been identified as a promising agent for intermittent preventive treatment of malaria in pregnancy.
Allen, Elizabeth, Kapulula, Mayamiko, Phiri, Kamija S., Maartens, Gary, Workman, Lesley, Banda, Clifford G, Munharo, Steven, Barnes, Karen I, Mwapasa, Victor, Ter Kuile, Feiko; id_orcid, Muyaya, Sharon, ter Kuile, Feiko O, Barnes, Karen I., Nkosi, Dumisile, ter Kuile, Feiko O., Phiri, Kamija S, Chirwa, Marumbo, Tarning, Joel, Banda, Clifford G., Madanitsa, Mwayiwawo   +19 more
core   +1 more source

Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2021
Artemisinin-based combination therapy (ACT), such as artemisinin-piperaquine (AP), dihydroartemisinin-piperaquine (DP), and artemether-lumefantrine (AL), is the first-line treatment for malaria in many malaria-endemic areas. However, we lack a detailed evaluation of the cardiotoxicity of these ACTs.
Wanting Wu, Chenguang Lu, Yuan Liang, Hongying Zhang, Changsheng Deng, Qi Wang, Qin Xu, Bo Tan, Chongjun Zhou, Jianping Song   +9 more
openaire   +5 more sources

Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium vivax malaria in endemic countries: meta-analysis of randomized controlled studies [PDF]

, 2013
Background: This study aimed to synthesize available evidence on the efficacy of dihydroartemisinin-piperaquine (DHP) in treating uncomplicated Plasmodium vivax malaria in people living in endemic countries.
Cho Naing (492196), Vanessa Racloz (321919), Marcel Tanner (33894), Maxine Anne Whittaker (492197), Joon Wah Mak, Aung Kyan, Marcel Tanner, Naing, Cho, Maxine Anne Whittaker, Cho Naing, Naing Cho, Racloz, Vanessa, Racloz Vanessa, Whittaker, Maxine Anne, Vanessa Racloz, Joon Wah Mak (207190), Kyan Aung, Tanner, Marcel, Mak, Joon Wah, Mak Joon Wah, Simon Andrew Reid, Simon Andrew Reid (492199), Reid, Simon Andrew, Tanner Marcel, Reid Simon Andrew, Aung, Kyan, Whittaker Maxine Anne, Kyan Aung (492198)   +27 more
core   +1 more source

Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches. [PDF]

Br J Clin Pharmacol
In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment ...
Tully MK, Commons RJ, Simpson JA, Price DJ.   +3 more
europepmc   +2 more sources

Efficacy and safety of dihydroartemisinin-piperaquine [PDF]

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2007
Dihydroartemisinin-piperaquine, a fixed-dose combination antimalarial, is an inexpensive, safe and highly effective treatment for uncomplicated falciparum or vivax malaria. Efficacy assessed over 28-63 days has consistently exceeded 95% in the treatment of multidrug-resistant falciparum malaria.
Myint, H, Ashley, E, Day, N, Nosten, F, White, N   +4 more
openaire   +4 more sources