Results 41 to 50 of about 6,372 (199)

Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in the setting of three different chemopreventive regimens. [PDF]

, 2015
BACKGROUND: The burden of malaria remains high for children in parts of Africa despite the use of insecticide-treated bed nets (ITNs). Chemoprevention has the potential of reducing the malaria burden; however, limited data exist on the efficacy and ...
Tamara Clark, Grant Dorsey, Achan, Jane, Dorsey, Grant, Mwangwa, Florence, Kapisi, James, Kamya, Moses, Seyi Soremekun, Moses Kamya, Bigira, Victor, Soremekun, Seyi, Florence Mwangwa, Clark, Tamara, Kinara, Stephen, James Kapisi, Victor Bigira, Stephen Kinara, Jane Achan   +17 more
core   +1 more source

Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis.

PLoS Medicine, 2017
BackgroundArtemisinin-based combination therapies (ACTs) are the mainstay of the current treatment of uncomplicated Plasmodium falciparum malaria, but ACT resistance is spreading across Southeast Asia.
Richard M Hoglund, Lesley Workman, Michael D Edstein, Nguyen Xuan Thanh, Nguyen Ngoc Quang, Issaka Zongo, Jean Bosco Ouedraogo, Steffen Borrmann, Leah Mwai, Christian Nsanzabana, Ric N Price, Prabin Dahal, Nancy C Sambol, Sunil Parikh, Francois Nosten, Elizabeth A Ashley, Aung Pyae Phyo, Khin Maung Lwin, Rose McGready, Nicholas P J Day, Philippe J Guerin, Nicholas J White, Karen I Barnes, Joel Tarning   +23 more
doaj   +1 more source

Adherence to Dihydroartemisinin + Piperaquine Treatment Regimen in Low and High Endemic Areas in Indonesia

Journal of Tropical Medicine, 2022
After decades of successful artemisinin regimen in combating malaria, its effectiveness has decreased since parasite resistance to the treatment regimen has begun to appear. Adherence to artemisinin combination therapy (ACT) in a population is considered
Irfanul Chakim, Tepanata Pumpaibool, null Sayono, Ekha Rifki Fauzi   +3 more
doaj   +1 more source

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra, Xue‐Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang‐Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang, Zhao‐Xun Liang   +10 more
wiley   +2 more sources

Choreoathetosis – an unusual adverse effect of dihydroartemisinin-piperaquine: a case report

Journal of Medical Case Reports, 2017
Background Dihydroartemisinin-piperaquine is a combination of dihydroartemisinin and piperaquine which is highly effective in the treatment of uncomplicated falciparum malaria. Its adverse effects are generally tolerable and temporary.
Benjamin Momo Kadia, Christian Morfaw, Armelle Corrine Gounoue Simo   +2 more
doaj   +1 more source

Efficacy of two versus three-day regimens of dihydroartemisinin-piperaquine for uncomplicated malaria in military personnel in northern Cambodia: an open-label randomized trial.

PLoS ONE, 2014
IntroductionEmerging antimalarial drug resistance in mobile populations remains a significant public health concern. We compared two regimens of dihydroartemisinin-piperaquine in military and civilians on the Thai-Cambodian border to evaluate national ...
Chanthap Lon, Jessica E Manning, Pattaraporn Vanachayangkul, Mary So, Darapiseth Sea, Youry Se, Panita Gosi, Charlotte Lanteri, Suwanna Chaorattanakawee, Sabaithip Sriwichai, Soklyda Chann, Worachet Kuntawunginn, Nillawan Buathong, Samon Nou, Douglas S Walsh, Stuart D Tyner, Jonathan J Juliano, Jessica Lin, Michele Spring, Delia Bethell, Jaranit Kaewkungwal, Douglas Tang, Char Meng Chuor, Prom Satharath, David Saunders   +24 more
doaj   +1 more source

A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan

Malaria Journal, 2012
Background Pregnancy is associated with an increased risk of developing a malaria infection and a higher risk of developing severe malaria. The pharmacokinetic properties of many anti-malarials are also altered during pregnancy, often resulting in a ...
Hoglund Richard M, Adam Ishag, Hanpithakpong Warunee, Ashton Michael, Lindegardh Niklas, Day Nicholas PJ, White Nicholas J, Nosten Francois, Tarning Joel   +8 more
doaj   +1 more source

Incomplete Plasmodium falciparum growth inhibition following piperaquine treatment translates into increased parasite viability in the in vitro parasite reduction ratio assay

Frontiers in Cellular and Infection Microbiology
Antimalarial resistance to the first-line partner drug piperaquine (PPQ) threatens the effectiveness of artemisinin-based combination therapy. In vitro piperaquine resistance is characterized by incomplete growth inhibition, i.e.
Annabelle Walz, Annabelle Walz, Sibylle Sax, Sibylle Sax, Christian Scheurer, Christian Scheurer, Balint Tamasi, Balint Tamasi, Pascal Mäser, Pascal Mäser, Sergio Wittlin, Sergio Wittlin   +11 more
doaj   +1 more source

Pyronaridine–artesunate or dihydroartemisinin–piperaquine combined with single low-dose primaquine to prevent Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a four-arm, single-blind, phase 2/3, randomised trial

The Lancet Microbe, 2022
Summary: Background: Pyronaridine–artesunate is the most recently licensed artemisinin-based combination therapy. WHO has recommended that a single low dose of primaquine could be added to artemisinin-based combination therapies to reduce Plasmodium ...
William Stone, PhD, Almahamoudou Mahamar, MD, Koualy Sanogo, MD, Youssouf Sinaba, MD, Sidi M Niambele, PharmD, Adama Sacko, MS, Sekouba Keita, MS, Ahamadou Youssouf, PharmD, Makonon Diallo, MD, Harouna M Soumare, PharmD, Harparkash Kaur, PhD, Kjerstin Lanke, BSc, Rob ter Heine, PhD, John Bradley, PhD, Djibrilla Issiaka, MD, Halimatou Diawara, MD, Sekou F Traore, PhD, Teun Bousema, ProfPhD, Chris Drakeley, ProfPhD, Alassane Dicko, ProfMD   +19 more
doaj   +1 more source

Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.

, 2006
In Rwanda, amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) is the current first-line treatment for malaria, introduced in 2001 as an interim strategy before the future deployment of an artemisinin-based combination treatment (ACT).
van Overmeir, C, Karema, Corine, Ngamije, D., D'Alessandro, U., Ngamije, D, Fanello, C. I., van Doren, W., van Doren, W, Karema, C., Fanello, Caterina I, Fanello, Caterina I., D'Alessandro, Umberto, Van Overmeir, C., Fanello, CI, d' Alessandro, Umberto, van Geertruyden, Jean-Pierre, Ngamije, Daniel, van Overmeir, Chantal, van Doren, Walli, D'Alessandro, U, Karema, C, van Geertruyden, JP, Van Geertruyden, J. P.   +22 more
core   +1 more source