Results 51 to 60 of about 6,372 (199)

Safety of Prenatal Anti‐Infective Use and Offspring Outcomes: A Panoramic Assessment by Indication, Drug Class, and Exposure Characteristics

iMetaMed, EarlyView.
Based on the comprehensive, panoramic assessment of the safety of prenatal anti‐infective use across indications, drug classes, and exposure characteristics, potential safety signals associated with prenatal exposure to several widely used anti‐infective drug classes were identified, including macrolides, metronidazole, tetracyclines, sulfonamides ...
Wenling Wang, Yuezhen Li, Chunrong Liu, Chen Chen, Meng Chen, Lehana Thabane, Xin Sun, Jing Tan   +7 more
wiley   +1 more source

Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

Malaria Journal, 2017
Background Artemisinin resistance is associated with delayed parasite clearance half-life in vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both phenotypes are associated with mutations in the PF3D7_1343700 pfkelch13 gene.
Angana Mukherjee, Selina Bopp, Pamela Magistrado, Wesley Wong, Rachel Daniels, Allison Demas, Stephen Schaffner, Chanaki Amaratunga, Pharath Lim, Mehul Dhorda, Olivo Miotto, Charles Woodrow, Elizabeth A. Ashley, Arjen M. Dondorp, Nicholas J. White, Dyann Wirth, Rick Fairhurst, Sarah K. Volkman   +17 more
doaj   +1 more source

Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis.

PLoS ONE, 2022
BackgroundSub-Saharan Africa has the highest burden of malaria in the world. Artemisinin-based combination therapies (ACTs) have been the cornerstone in the efforts to reduce the global burden of malaria.
Karol Marwa, Anthony Kapesa, Vito Baraka, Evelyne Konje, Benson Kidenya, Jackson Mukonzo, Erasmus Kamugisha, Gote Swedberg   +7 more
doaj   +2 more sources

Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia

Emerging Infectious Diseases, 2018
We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P.
Jean Popovici, Amelie Vantaux, Lyse Primault, Reingsey Samreth, Eak Por Piv, Sophalai Bin, Saorin Kim, Dysoley Lek, David Serre, Didier Menard   +9 more
doaj   +1 more source

The Knockout for G Protein-Coupled Receptor-Like PfSR25 Increases the Susceptibility of Malaria Parasites to the Antimalarials Lumefantrine and Piperaquine but Not to Medicine for Malaria Venture Compounds

Frontiers in Microbiology, 2021
Previously we have reported that the G protein-coupled receptor (GPCR)-like PfSR25 in Plasmodium falciparum is a potassium (K+) sensor linked to intracellular calcium signaling and that knockout parasites (PfSR25-) are more susceptible to oxidative ...
Benedito M. Santos, Bárbara K. M. Dias, Myna Nakabashi, Celia R. S. Garcia   +3 more
doaj   +1 more source

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

An Efficient, Green Chemical Synthesis of the Malaria\ud Drug, Piperaquine [PDF]

, 2013
To provide a robust, efficient synthesis of the malaria drug piperaquine for potential use in resource-poor settings. We used in-process analytical technologies (IPAT; HPLC) and a program of experiments to develop a synthesis of piperaquine that avoids ...
Fortunak, Joseph MD, Thompson, Keeshaloy, King, Christopher L, Byrn, Stephen R, Dyson, Brandon, Ellison, Tiffany, Conrad, Chelsea, Lee, Mindy, Kulkarni, Amol A, Ekeocha, Zita   +9 more
core  

Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial [PDF]

, 2009
BACKGROUND: Artemisinin combination therapies (ACTs) are currently the preferred option for treating uncomplicated malaria. Dihydroartemisinin-piperaquine (DHA-PQP) is a promising fixed-dose ACT with limited information on its safety and efficacy in ...
Corsi Marco, Nambozi Michael, Bassat Quique, Piola, Patrice, Nabasumba, C., Umberto D'Alessandro, Bassat, Q., D'Alessandro Umberto, Halidou Tinto, D’Alessandro, U., Clara Menéndez, Nabasumba Carolyn, Valéa Innocent, Ubben, D., Borrmann Steffen, Mulenga Modest, Corsi, M., Mulenga, Modest, Nambozi, M., Talisuna, A., Tinto, Halidou, Vale´a, I., David Ubben, Innocent Valéa, Sasi Philip, Marco Corsi, Piola Patrice, Bacchieri, Antonella, Sasi, P., Nabasumba, Carolyn, Bacchieri, A., Michael Nambozi, Ambrose Talisuna, Carolyn Nabasumba, Nambozi, Michael, Valéa, Innocent, Philip Sasi, Menéndez, Clara, Talisuna, Ambrose, Menéndez Clara, Patrice Piola, Ubben, David, Sasi, Philip, Antonella Bacchieri, Borrmann, S., Tinto Halidou, Bassat, Quique, D'Alessandro, Umberto, Tinto, H., Mulenga, M., Bacchieri Antonella, Piola, P., Borrmann, Steffen, Corsi, Marco, Talisuna Ambrose, Ubben David, Quique Bassat, Modest Mulenga, Steffen Borrmann, Mene´ndez, C.   +59 more
core   +1 more source

Pharmacokinetics of a Novel Piperaquine Dispersible Granules Formulation Under Fasting and Various Fed Conditions Versus Piperaquine Tablets When Fasted in Healthy Tanzanian Adults: A Randomized, Phase I Study

Clinical and Translational Science
Piperaquine tetraphosphate (PQP), a long‐acting antimalarial, is being considered in a combination for chemoprevention. Dihydroartemisinin‐piperaquine tablets (hard and dispersible) approved for the treatment of acute uncomplicated malaria should be ...
Florence A. Milando, Said Jongo, Salim Abdulla, Gloria Nyaulingo, Anneth‐Mwasi Tumbo, Sarah Mswata, Juliether Tiago, Beatus S. Bongole, Ashura Mirambo, Kamaka Kassimu, Hussein Mbarak, Mohammed A. Rashid, Ali Hamad, Michael Mihayo, Tunu Ndanzi, Omary Zuberi, Naima Saadia, Mariam Somboka, Mariam Yamba‐Yamba, Theresia Ngonyani, Amina Nditi, Margaret Msuya, Bakari Mwalimu, Hajirani M. Msuya, Khamis Awadh, Ali Ali, Anne Claire Marrast, Denis Gossen, Alice Neequaye, Myriam El‐Gaaloul, Hanu Ramachandruni, Isabelle Borghini‐Fuhrer   +31 more
doaj   +1 more source

Treatment Failure of Dihydroartemisinin/Piperaquine for Plasmodium falciparum Malaria, Vietnam

Emerging Infectious Diseases, 2017
We conducted a study in Binh Phuoc, Vietnam, in 2015 on the therapeutic efficacy of dihydroartemisinin/piperaquine for Plasmodium falciparum malaria.
Bui Quang Phuc, Charlotte Rasmussen, Tran Thanh Duong, Le Than Dong, Mai Anh Loi, Didier Ménard, Joel Tarning, Dorina Bustos, Pascal Ringwald, Gawrie Loku Galappaththy, Nguyen Quang Thieu   +10 more
doaj   +1 more source