Results 11 to 20 of about 97,443 (299)
Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry [PDF]
ChemistryOpenInterest in piperazine scaffolds continues to rise due to their broad relevance across anti‐infective, anticancer, and neuroactive research. This review examines reports published from 2014 to 2024 and organizes current developments by therapeutic class,
Assel Ten +5 more
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Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo
Nature Communications, 2022 In humans, lipid nanoparticles (LNPs) have safely delivered therapeutic RNA to hepatocytes after systemic administration and to antigen-presenting cells after intramuscular injection. However, systemic RNA delivery to non-hepatocytes remains challenging,
Huanzhen Ni +10 more
semanticscholar +1 more source
Synthetic Approaches to Piperazine-Containing Drugs Approved by FDA in the Period of 2011–2023
Molecules, 2023 The piperazine moiety is often found in drugs or in bioactive molecules. This widespread presence is due to different possible roles depending on the position in the molecule and on the therapeutic class, but it also depends on the chemical reactivity of
M. Romanelli +5 more
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Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids [PDF]
, 2015 We have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids.
Agata Paneth +12 more
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Gastroenterology, 1976 The first reported case of piperazine toxicity resembling viral hepatitis is described in a 25-year-old woman. The illness, which was severe, occurred after administration of the drug on two separate occasions. The evidence favors a hypersensitivity mechanism rather than a direct toxic effect of piperazine or its metabolites on the liver.
A N, Hamlyn +3 more
openaire +2 more sources
Egyptian Journal of Forensic Sciences, 2014 Piperazine-related drugs are sold as party pills in the form of tablets, capsules, liquids or powders. These party pills can contain several piperazine derivatives, or even a mixture of piperazines and amphetamine derivatives.
Yacine Boumrah +5 more
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Acta Crystallographica Section E: Crystallographic Communications, 2021 The amine 8-{4-[(6-phenylpyridin-3-yl)methyl]piperazin-1-yl}-3,4-dihydroquinolin-2(1H)-one was crystallized as the hydrochloride salt, 4-(2-oxo-1,2,3,4-tetrahydroquinolin-8-yl)-1-[(6-phenylpyridin-3-yl)methyl]piperazin-1-ium chloride, C25H27N4+·Cl− (I ...
Nisar Ullah, Helen Stoeckli-Evans
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Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones [PDF]
, 2009 Two series of novel rigid pyrazolone derivatives were synthesized and evaluated as inhibitors of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. Two of these compounds showed a high activity against MTB (MIC = 4 μg/mL).
Alessandro De Logu +19 more
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Piperazine based antimicrobial polymers: a review
RSC Advances, 2021 Microbial infections are a life threatening concern in several areas, which include the biomedical sector, healthcare products, water purification systems, and food packaging.
Manohara Dhulappa Jalageri +2 more
semanticscholar +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2022 Crystal structures are reported for two molecular salts containing the 4-(4-nitrophenyl)piperazin-1-ium cation. Co-crystallization from methanol/ethyl acetate solution of N-(4-nitrophenyl)piperazine with benzoic acid gives the benzoate salt, which ...
Holehundi J. Shankara Prasad +5 more
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