Results 21 to 30 of about 97,443 (299)

Piperazine-substituted derivatives of favipiravir for Nipah virus inhibition: What do in silico studies unravel?

SN Applied Sciences, 2021
Favipiravir is found to show excellent in-vitro inhibition activity against Nipah virus. To explore the structure–property relationship of Favipiravir, in silico designing of a series of piperazine substituted Favipiravir derivatives are attempted and ...
R. Lipin, A. K. Dhanabalan, K. Gunasekaran, R. V. Solomon   +3 more
semanticscholar   +1 more source

Copper(II) Complexes with Tetradentate Piperazine-Based Ligands: DNA Cleavage and Cytotoxicity

Inorganics, 2021
Five-coordinate Cu(II) complexes, [Cu(Ln)X]ClO4/PF6, where Ln = piperazine ligands bearing two pyridyl arms and X = ClO4− for Ln = L1 (1-ClO4), L2 (2-ClO4), L3 (3-ClO4), and L6 (6-ClO4) as well as [Cu(Ln)Cl]PF6 for Ln = L1 (1-Cl), L4 (4-Cl), and L5 (5-Cl)
Sebastian Doniz Kettenmann, Yvonne Nossol, Febee R. Louka, Julia R. Legrande, Elise Marine, Roland C. Fischer, Franz A. Mautner, Vinja Hergl, Nora Kulak, Salah S. Massoud   +9 more
doaj   +1 more source

Caenorhabditis elegans muscle Cys-loop receptors as novel targets of terpenoids with potential anthelmintic activity [PDF]

, 2019
The anthelmintic treatment of nematode infections remains the pillar of worm control in both human and veterinary medicine. Since control is threatened by the appearance of drug resistant nematodes, there is a need to develop novel compounds, among which
Bouzat, Cecilia Beatriz, Hernando, Guillermina Silvana, Turani, Ornella   +2 more
core   +1 more source

Worm eggs: Cost you money [PDF]

, 1962
Contents One Million Eggs Daily.......... 3 Damaging Trip......... 4 Worm Remedies......... 5 Modern Worm Remedies......... 6 A Control Program..........
Frolik, E.F., Janike, E.W.
core   +3 more sources

Six 1-aroyl-4-(4-methoxyphenyl)piperazines: similar molecular structures but different patterns of supramolecular assembly

Acta Crystallographica Section E: Crystallographic Communications, 2019
Six new 1-aroyl-4-(4-methoxyphenyl)piperazines have been prepared, using coupling reactions between benzoic acids and N-(4-methoxyphenyl)piperazine.
Haruvegowda Kiran Kumar, Hemmige S. Yathirajan, Belakavadi K. Sagar, Sabine Foro, Christopher Glidewell   +4 more
doaj   +1 more source

Benzimidazoles Containing Piperazine Skeleton at C-2 Position as Promising Tubulin Modulators with Anthelmintic and Antineoplastic Activity

Pharmaceuticals, 2023
Benzimidazole anthelmintic drugs hold promise for repurposing as cancer treatments due to their interference with tubulin polymerization and depolymerization, manifesting anticancer properties.
Kameliya Anichina, Anelia Mavrova, Dimitar Vuchev, Galya Popova-Daskalova, Giada Bassi, Arianna Rossi, Monica Montesi, Silvia Panseri, Filip Fratev, Emilia Naydenova   +9 more
doaj   +1 more source

Metallocene-Naphthalimide Derivatives: The Effect of Geometry, DFT Methodology, and Transition Metals on Absorption Spectra

Molecules, 2023
In the present paper, the photophysical properties of metallocene-4-amino-1,8-naphthalimide-piperazine molecules (1-M2+), as well as their oxidized and protonated derivatives (1−M3+, 1-M2+-H+, and 1-M3+-H+), where M = Fe, Co, and Ni, were studied via DFT
Christina Eleftheria Tzeliou, Demeter Tzeli   +1 more
doaj   +1 more source

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source

Biopolymer Modified with Piperazine-2- Carboxylic Acid for Carbon Dioxide Adsorption

Chemical Engineering Transactions, 2013
A new adsorbent biopolymer, piperazine bipolymer (PBP), was successfully modified with a piperazine derivative for CO2 adsorption. The biopolymer was purified by an alkali treatment to obtain 96.43 % degree of deacetylation and used as the reactive ...
C. Saiwan, S. Srisuwanvichien, P. Tontiwachwuthikul   +2 more
doaj   +1 more source

Fragment-based discovery of a regulatory site in thioredoxin glutathione reductase acting as "doorstop" for NADPH entry [PDF]

, 2018
Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases.
Angelucci, Francesco, Ardini, Matteo, Arner, Elias S. J., Bellelli, Andrea, Boumis, Giovanna, Chen, Qing, Fata, Francesca, Ippoliti, Rodolfo, Jadhav, Ajit, Lea, Wendy A., Lyu, Haining, Miele, Adriana E., Petukhov, Pavel A., Silvestri, Ilaria, Simeonov, Anton, Thatcher, Gregory R. J., Williams, David L.   +16 more
core   +4 more sources